With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
50777-76-9, General procedure: (S)-2-{[4-(Methoxycarbonylpropyl]phenyl)aminocarbonyl}indoline (3; 676 mg, 2 mmol) and 2-(diphenylphosphino)benzaldehyde (2a;1.16 g, 4 mmol) were dissolved in MeOH (5 mL). The reaction mixture was heated to 80 ¡ãC in a sealed tube for 48 h. After cooling to r.t., the mixture was extracted with EtOAc and concentrated. The resulting residue was chromatographed on silica gel (eluent:acetone/hexane = 1:2) to give colorless fine prisms; yield: 840 (69percent); mp 115?117 ¡ãC; [alpha]D21 ?169 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 7.71 (d, J = 6.5 Hz, 1 H), 7.43?7.13 (m,18 H), 6.97?6.91 (m, 3 H), 4.37 (d, J = 8.5 Hz, 1 H), 3.64 (s, 3 H), 3.53 (d,J = 16.5 Hz, 1 H), 3.09 (dd, J = 8.5, 16.5 Hz, 1 H), 2.52 (t, J = 7.5 Hz, 2 H),2.26 (t, J = 7.5 Hz, 2 H), 1.85 (quin, J = 7.5 Hz, 2 H).13C NMR (126 MHz, CDCl3): delta = 174.1, 173.6, 142.3?113.5 (Carom, overlapped), 81.4 (d, JC,P = 25.9 Hz), 64.1, 51.3, 34.3, 33.1, 31.4, 26.1. 31P{1H} NMR (202 MHz, CDCl3): delta = ?18.9 (s).MS (ESI-TOF): m/z = 633 [M + Na]+.
The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Uozumi, Yasuhiro; Matsuura, Yutaka; Suzuka, Toshimasa; Arakawa, Takayasu; Yamada, Yoichi M. A.; Synthesis; vol. 49; 1; (2017); p. 59 – 68;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate