Day: October 15, 2020

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A degassed dichloromethane (25.0?mL) solution of [RuCl2(PPh3)3] (96?mg; 0.10?mmol) and dppf (60.0?mg; 0.11?mmol), in a Schlenk flask, was stirred for 30?min followed by the addition of 0.10?mmol of the polypyridyl ligand. After 30?min of stirring the resulting solution was concentrated until ca. 5?mL and addition of 10?mL of diethyl ether afforded a solid, which was collected by filtration, washed with diethyl ether and dried under vacuum.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Davila-Rodriguez, Maria?Jose; Barolli, Joao Paulo; de Oliveira, Katia Mara; Colina-Vegas, Legna; da Silva Miranda, Fabio; Castellano, Eduardo Ernesto; Von Poelhsitz, Gustavo; Batista, Alzir Azevedo; Archives of Biochemistry and Biophysics; vol. 660; (2018); p. 156 – 167;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: (S)-2-{[4-(Methoxycarbonylpropyl]phenyl)aminocarbonyl}indoline (3; 676 mg, 2 mmol) and 2-(diphenylphosphino)benzaldehyde (2a;1.16 g, 4 mmol) were dissolved in MeOH (5 mL). The reaction mixture was heated to 80 ¡ãC in a sealed tube for 48 h. After cooling to r.t., the mixture was extracted with EtOAc and concentrated. The resulting residue was chromatographed on silica gel (eluent:acetone/hexane = 1:2) to give colorless fine prisms; yield: 840 (69percent); mp 115?117 ¡ãC; [alpha]D21 ?169 (c 1.0, CHCl3). 1H NMR (500 MHz, CDCl3): delta = 7.71 (d, J = 6.5 Hz, 1 H), 7.43?7.13 (m,18 H), 6.97?6.91 (m, 3 H), 4.37 (d, J = 8.5 Hz, 1 H), 3.64 (s, 3 H), 3.53 (d,J = 16.5 Hz, 1 H), 3.09 (dd, J = 8.5, 16.5 Hz, 1 H), 2.52 (t, J = 7.5 Hz, 2 H),2.26 (t, J = 7.5 Hz, 2 H), 1.85 (quin, J = 7.5 Hz, 2 H).13C NMR (126 MHz, CDCl3): delta = 174.1, 173.6, 142.3?113.5 (Carom, overlapped), 81.4 (d, JC,P = 25.9 Hz), 64.1, 51.3, 34.3, 33.1, 31.4, 26.1. 31P{1H} NMR (202 MHz, CDCl3): delta = ?18.9 (s).MS (ESI-TOF): m/z = 633 [M + Na]+.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uozumi, Yasuhiro; Matsuura, Yutaka; Suzuka, Toshimasa; Arakawa, Takayasu; Yamada, Yoichi M. A.; Synthesis; vol. 49; 1; (2017); p. 59 – 68;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 0.0243 g CuSCN (0.2 mmol), 0.0464 g dpq(0.2 mmol) and 0.1077 g pop (0.2 mmol) were dissolved in the mixed solvents of 5 mL CH3OH and 5 mL CH2Cl2, stirred at room temperature for 6 h. The filtrate was evaporated slowly at room temperature for around 5 days to yield yellow crystalline products.Yield: 77%. Anal. Calc. for C51H36CuN5OP2S: C, 68.60; H, 4.03; N,7.80. Found: C, 66.60; H, 4.23; N, 7.60%. 1H NMR (600 MHz, DMSO,298 K): delta, ppm: 6.66-7.42 (m, pop-aromatic ring), 7.98-9.53 (m,dpq-heteroaromatic ring); 31P NMR (600 MHz, DMSO, 298 K): delta,ppm: 11.65 (s, pop). IR for 9 (KBr pellets, cm-1): 3425(w), 2048(vs), 1564(w), 1434(vs), 1386(s), 1218(s), 1122(m), 998(w), 753(s), 512(s), 420(w)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kuang, Xiao-Nan; Lin, Sen; Liu, Jian-Ming; Han, Hong-Liang; Liu, Min; Xin, Xiu-Lan; Yang, Yu-Ping; Li, Zhong-Feng; Jin, Qiong-Hua; Li, Si-Fan; Li, Yue-Xue; Feng, Yue-Bing; Polyhedron; vol. 165; (2019); p. 51 – 62;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of N,N,N’-trisubstitutedacyl thiourea (0.564mmol) and phosphine ligand (0.564mmol) in a minimal amount of methanol, was added drop wise to a solution of K2PdCl4 (0.564mmol) in 40mL of methanol at 50?60¡ãC. The resulting mixture was stirred for 3?4 h and the precipitated complexes (1?8) (Scheme 1 ) were filtered, and washed with methanol. Single crystal X-ray diffraction measurement quality crystals were obtained by slow evaporation of chloroform/methanol (3:1) solution of the complexes. The 1H and 13C NMR, FT-IR, the elemental analyses, melting point data for the complexes (1?8) are as follows:(6) (Tri(m-tolyl)phosphine-kappaP)(1-(4-fluorobenzoyl)-3-(N-methylphenyl) thioureido-kappa2(O, S)palladium(II) chloride Quantities used were 0.184?g (0.564?mmol) K2PdCl4, 0.163?g (0.564?mmol) 1-(4-fluorobenzoyl)-3-(N-methylphenyl)thiourea, 0.172?g (0.564?mmol) tri(m-tolyl)phosphine in methanol. Yield???80percent; Orange solid; m.p. 192-194?¡ãC. FTIR (cm-1); 3142(w), 2998(w), 2879(w), 1617(m), 1509(s), 1422(s), 1362(w), 1310(w), 1244(w), 1192(w), 1090(m), 1064(w), 1020(w), 990(w), 940(m), 916(s), 864(s), 780(s), 746(s), 690(s), 619(w). H NMR (300?MHz, CDCl3) delta 2.30 [(s, 9H, 3(-CH3)],3.59 (s, 3H, N-CH3), 6.86-8.41 (m, 21H, ArH); 13C NMR (75.5?MHz, CDCl3) delta 21.3 (3C), 42.2 (C), 114.7 & 114.9 (2C, d, 13C-19F, 2J?=?19.7?Hz), 127.0 (C), 127.6 (C), 127.8 (C), 127.9 (C), 128.4 (C), 129.3 (C), 132.0 (C), 132.7 & 132.9 (2C, d, 13C-19F, 3J?=?10.6?Hz), 135.3 &137.9 (1C, d, 13C-19F, 1J?=?272.0?Hz), 135.4(C), 137.8 (C), 145.5 (C), 168.7 (C), 171.0 (1C, C=O), 173.8 (1C, C=S); 31P NMR (121.5?MHz, CDCl3) delta 34.80; Anal. Calc. for C36H33ClFN2OPPdS (Mol. mass: 733.57) C, 58.94; H, 4.53; N, 3.82; S, 4.37. Found: C, 58.99; H, 4.58; N, 3.89; S, 4.42.

6224-63-1, 6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Khan, Muhammad Riaz; Zaib, Sumera; Khan, Azim; Badshah, Amin; Rauf, Muhammad Khawar; Imtiaz-ud-Din; Tahir, Muhammad Nawaz; Shahid, Muhammad; Iqbal, Jamshed; Inorganica Chimica Acta; vol. 479; (2018); p. 189 – 196;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: A mixture of Tetrakis(acetonitrile)copper(I) tetrafluoroborate ([Cu(NCCH3)4]BF4, 3.11 g, 33.0 mmol) and Bis[(2-diphenylphosphino)phenyl]ether (O[C6H4P(C6H5)2]2, DPEphos, 5.33 g, 33.0 mmol) in 300 ml of CH2Cl2 was stirred at room temperature for 3 h. Upon addition of 1,10-Phenanthroline (C12H8N2, phen, 1.78 g, 33.0 mmol) the clear solution turned bright yellow, remained clear, and was stirred for an additional 2 h. Approximately 900 ml of diethyl ether ((CH3CH2)2O) was added to the solution to precipitate a bright yellow solid. The solution containing the newly precipitated solid was then left in the refrigerator for one day. It was vacuum filtered using a medium frit, washed with diethyl ether and dried under vacuum. A bright yellow powder was isolated (yield: 8.00 g, 93 percent)., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kubi?ek, Katharina; Thekku Veedu, Sreevidya; Storozhuk, Darina; Kia, Reza; Techert, Simone; Polyhedron; vol. 124; (2017); p. 166 – 176;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: A mixture of AgBr (0.018g, 0.1mmol), diphenyl(p-tolyl) phosphine (P5) 0.028g (0.1mmol) and thiosemicarbazide (L1) 0.018g (0.2mmol) in 20ml of acetone/ methanol (1:1) was refluxed with continuous mechanical stirring overnight at 70C. The light yellow transparent solution obtained was filtered to avoid any impurity and slow addition of water resulted precipitation of final product. The product was collected by filtration, washed with water and dried. Again in situ transformation of L1 to L2 had taken place. Yield 0.078g, 89%. Anal. Calc. for C42H43AgBrN3P2S: C, 57.8; H, 4.9; N, 4.8. Found: C, 57.8; H, 4.9; N, 4.8%. IR cm-1: 3531 (w), 3479 (m), 3413 (m), 3119 (s), 2926 (s), 2842 (s), 1633 (s), 1608 (s), 1546 (m), 1456 (s), 1384 (s), 1148 (m), 1058 (s), 989 (ms), 819 (m), 767 (m), 666 (s), 521 (m).

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Altaf, Muhammad; Stoeckli-Evans, Helen; Cuin, Alexandre; Sato, Daisy Nakamura; Pavan, Fernando Rogerio; Leite, Clarice Queico Fujimura; Ahmad, Saeed; Bouakka, Mohammed; Mimouni, Mostafa; Khardli, Fatima Zahra; Hadda, Taibi Ben; Polyhedron; vol. 62; (2013); p. 138 – 147;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6737-42-4,1,3-Bis(diphenylphosphino)propane,as a common compound, the synthetic route is as follows.

6737-42-4, Preparation 12 A mixture of 4-[2-(tert-butoxycarbonylamino)ethyl]-phenyl trifluoromethanesulfonate (6.11 g, 16.6 mmol), palladium(II) acetate (745 mg, 3.32 mmol), 1,3-bis-(diphenylphosphino)propane (1.37 g, 3.32 mmol), triethylamine (6.94 ml, 49.8 mmol), and MeOH (24ml) in DMF (60 ml) was purged for 30 min with carbon monoxide. The mixture was stirred under carbon monoxide atmosphere at 78 C. for 3 hours. After cooling the mixture to room temperature, the reaction mixture was diluted with EtOAc, washed with water, 1N-hydrochloric acid, water, saturated sodium hydrogencarbonate, water and brine successively, dried over magnesium sulfate, and evaporated in vacuo. The residue was purified by silica gel column chromatography (hexane:EtOAc, 4:1-3:1) to give methyl 4-[2-(tert-butoxycarbonylamino)ethyl]benzoate (3.52 g, 76%). IR (KBr, cm-1): 3371, 2978, 2947, 1722, 1680, 1525, 1277 1H-NMR (CDCl3, delta): 1.43 (9H, s), 2.86 (2H, t, J=7.0 Hz),3.32-3.45 (2H, m), 3.91 (3H, s), 4.45-4.63 (1H, m), 7.27 (2H, d, J=8.3 Hz), 7.98 (2H, d, J=8.3 Hz) MS (m/z): 1 80 (M-C5H9O2+2H)+

6737-42-4 1,3-Bis(diphenylphosphino)propane 81219, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6437146; (2002); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

A mixture of [{(mu-SCH2)2CH2}Fe2(CO)6] (0.193 g, 0.5 mM), P(PhOMe-p)3 (0.211 g, 0.6 mM), and Me3NO¡¤2H2O (0.056 g, 0.5 mM) was dissolved in MeCN (15 mL) and was stirred at room temperature for 2 h to give a black-red solution. The solvent was removed on a rotary evaporator and the residue was subjected to preparative TLC separation using CH2Cl2/petroleum ether (v/v = 1 : 5) as eluent. From the main red band, 1 (0.241 g, 68%) was obtained as a red solid. M.p.: 180-181 C. Anal. Calcd for C29H27Fe2O8PS2: C, 49.04; H, 3.83%. Found: C, 48.93; H, 3.99%. IR (KBr disk, cm-1): nuC?O 2041 (vs), 1985 (vs), 1979 (vs), 1958 (vs), 1930 (vs). 1H NMR (400 MHz, CDCl3, TMS, ppm): 7.58 (t, 3JHH = 3JHP = 7.6 Hz, 6H, PhH), 6.93 (d, 3JHH = 7.6 Hz, 6H, PhH), 3.84 (s, 9H, OCH3), 1.78-1.72 (m, 2H, SCHaHe), 1.54-1.48 (m, 4H, SCHaHe and CH2). 13C{1H} NMR (100.6 MHz, CDCl3, TMS, ppm): 213.92 (d, 2JPC = 12.0 Hz, PFeCO), 209.83 (s, FeCO), 160.97 (s, ipso-PhCOMe), 134.97 (d, 2JPC = 12.3 Hz, o-PhCH), 127.55 (d, 1JPC = 44.8 Hz, ipso-PhCP), 114.00 (d, 3JPC = 10.5 Hz, m-PhCH), 55.37 (s, OCH3), 30.02 (s, CH2), 22.29 (s, SCH2). 31P{1H} NMR (161.9 MHz, CDCl3, 85% H3PO4, ppm): 60.26 (s).

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhao, Pei-Hua; Li, Xin-Hang; Liu, Yun-Feng; Liu, Ya-Qing; Journal of Coordination Chemistry; vol. 67; 5; (2014); p. 766 – 778;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, General procedure: To a flame dried two-neck round-bottom flask containing CsF (5.50 equiv.) was added o-silyl aryl triflate (II) (1.00 equiv.) in acetonitrile, followed by addition of phosphorous compound of formula (III) (4.00 equiv.) in acetonitrile under argon atmosphere. The reaction mixture was stirred at room temperature and the progress was monitored by TLC. After completion of the reaction, acetonitrile was removed on rotary evaporator and the crude product was dried under high vacuum and purified by flash silica gel column using a gradient of ethyl acetate-petroleum ether to afford corresponding aryl-phosphorous compounds of formula (I) in good to excellent yields. 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.083 mmol), Cesium Fluoride (70 mg, 0.461 mmol), Ethoxydiphenylphosphane (78 mg, 0.33 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf: 0.3 (1:3 EtOAc:Pet Ether); White Solid; 17.5 mg, 75%; 1H NMR (400 MHz, CDCl3, TMS) delta 7.74-7.63 (m, 6H), 7.59-7.51 (m, 3H), 7.50-7.40 (m, 6H); 13C NMR (100 MHz, CDCl3, TMS) delta 132.5 (d, J=104.0 Hz), 132.1 (d, J=10.0 Hz), 131.9 (d, J=2.3 Hz); 128.5 (d, J=12.4 Hz); 31P NMR (162 MHz, CDCl3) delta 29.2; Mass (M+Na)+ 301; Known Compound, Lit. K. Prokop, D. Goldberg, J. Am. Chem. Soc. 2012, 134, 8014

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Mhaske, Santosh Baburao; Dhokale, Ranjeet Ashokrao; US2015/210725; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

7650-91-1, A 100 mL round-bottomed flask was charged with 2.4 g of benzyl diphenyl phosphine, 1.4 g of benzylpyridine iridium(III) dichloro bridge dimer, 1.83 g of sodium carbonate and 100 mL of 2-ethoxyethanol. The reaction was stirred and heated at 135 C. for 6 h under nitrogen while protected from light with aluminum foil. The reaction mixture was cooled to ambient temperature and concentrated under reduced pressure(20 mmHg). A light brown solution was obtained and further purified by flash column chromatography on silica gel using dichloromethane and hexanes mixture as the eluent yielding 2 g (78%) of pure mer isomer was obtained.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Tsai, Yui-Yi; Barone, Michael S.; Tamayo, Arnold; Thompson, Mark E.; US2005/258742; (2005); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate