719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
719-80-2, Ethyl diphenylphosphinite (4.7 mL, 21.76 mmol) was combined with a solution of 2,6-bis(chloromethyl)pyridine (15.7g, 89.18 mmol) [13] in o-xylene (60 mL) under a nitrogen atmosphere, and the mixture was stirred (120 C, 2 h). After evaporation of solvent, the residue was purified by column chromatography (silica gel (230 g), CH2Cl2/MeOH, 100/0 to 97/3) leaving 1a as a white powder. Yield: 6.64 g, 89 %. Mp 118-120 C. Single crystals of 1a were obtained by slow evaporation of a CH2Cl2/Et2O (10/90) solution. 31P{1H} NMR (121.5 MHz, CDCl3): delta=30.5. 1H NMR (300 MHz, CDCl3): delta=7.75-7.69 (m, 4H, H9), 7.52 (t, JHH=7.8Hz, 1H, H4), 7.46-7.33 (m, 7H, H10,11 and H3 or H5), 7.18 (d, JHH=7.8Hz, 1H, H3 or H5), 4.42 (s, 2H, H7), 3.89 (d, JHP=14.4Hz, 2H, H1). 13C{1H} NMR (75.4 MHz, CDCl3): delta=155.9 (C6), 152.4 (d, JCP=7.0Hz, C2), 137.4 (C4), 132.3 (d, JCP=100.4Hz, C8), 131.8 (C11), 131.1 (d, JCP=9.5Hz, C9), 128.4 (d, JCP=11.9Hz, C10), 124.2 (d, JCP=3.2Hz, C5), 120.8 (C3), 46.5 (C7), 40.9 (d, JCP=64.0Hz, C1). IR (KBr, cm-1): nu = 3057, 2923, 1612, 1589, 1575, 1483, 1455, 1433, 1397, 1293, 1268, 1249, 1225, 1200 (nuP=O), 1161, 1118, 1084, 1066, 1024, 992, 963, 858, 827, 813, 753, 734, 714, 699, 690, 618, 575, 543, 519, 490, 452, 435, 410. HRMS (ESI): m/z (%) = 342.0826 (100) [M+H+]. C19H18NOPCl requires 342.0815; 364.0635 (40) [M+Na+]. C19H17NOPClNa requires 364.0634. Anal. Calc. for C19H17ClNOP: C, 66.77; H, 5.01; N, 4.10. Found: C, 66.66; H, 4.86; N, 3.50 %
The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ouizem, Sabrina; Rosario Amorin, Daniel; Dickie, Diane A.; Cramer, Roger E.; Campana, Charles F.; Hay, Benjamin P.; Podair, Julien; Delmau, Laetitia H.; Paine, Robert T.; Polyhedron; vol. 97; (2015); p. 20 – 29;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate