With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
3-phenylpropyl-1-amine (344 ml;2.41 mmol) in 10 mL of toluene was added drop-wise to a mixtureof (2-(diphenylphosphino))-benzaldehyde (0.7 g; 2.41 mmol) andanhydrous magnesium sulfate (1.6 g) in toluene (10 mL). The reactionwas stirred under reflux for 3 h. Resulting in a light yellowmixture. After filtration a yellow oil was obtained upon eliminationof the solvent under reduced pressure. Twice the treatment withhexane (10 mL) resulted in a purification of the product, whichhowever did not crystallize. Yield: 97percent. 1H NMR (CDCl3, 298 K,300 MHz): d (ppm) 8.86 (d, J 4,65 Hz, 1H, HCN-), 7.98e7.94(m, 1H, aromatic), 7.38e7.04 (m, 17H, aromatic), 6,87-6,83 (m, 1H,aromatic), 3.48 (t, J 6.65 Hz, 2H, NCH2-), 2.44e2.39 (m, 2H,-CH2-Ph), 1.84e1.75 (m, 2H, -CH2-). 31P{1H} (CDCl3, 298 K):d (ppm)13.80. ESI-MS (CHCl3 after treatment of H2O2) m/z:424.2 [OPN3 H]., 50777-76-9
The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wajda-Hermanowicz, Katarzyna; Kochel, Andrzej; Wrobel, Robert; Journal of Organometallic Chemistry; vol. 860; (2018); p. 30 – 48;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate