Day: October 14, 2020

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.3.29 methyl 2-phenyl-5-(3-methylphenyl)oxazole-4-carboxylate ;(4i) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 117 mg (80percent). 1H NMR (300 MHz, CDCl3) delta 2.44 (s, 3H), 3.97 (s, 3H), 7.27 (d, J=7.7 Hz, 1H), 7.38 (t, J=7.7 Hz, 1H), 7.46-7.49 (m, 3H), 7.93-7.96 (m, 2H), 8.13-8.17 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 161.7, 158.7, 154.5, 137.2, 130.2, 130.1, 127.9, 127.8, 127.4, 126.9, 125.9, 125.4, 124.8, 51.4, 20.6 ppm., 6224-63-1

The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, Ethyl diphenylphosphinite (4.7 mL, 21.76 mmol) was combined with a solution of 2,6-bis(chloromethyl)pyridine (15.7g, 89.18 mmol) [13] in o-xylene (60 mL) under a nitrogen atmosphere, and the mixture was stirred (120 C, 2 h). After evaporation of solvent, the residue was purified by column chromatography (silica gel (230 g), CH2Cl2/MeOH, 100/0 to 97/3) leaving 1a as a white powder. Yield: 6.64 g, 89 %. Mp 118-120 C. Single crystals of 1a were obtained by slow evaporation of a CH2Cl2/Et2O (10/90) solution. 31P{1H} NMR (121.5 MHz, CDCl3): delta=30.5. 1H NMR (300 MHz, CDCl3): delta=7.75-7.69 (m, 4H, H9), 7.52 (t, JHH=7.8Hz, 1H, H4), 7.46-7.33 (m, 7H, H10,11 and H3 or H5), 7.18 (d, JHH=7.8Hz, 1H, H3 or H5), 4.42 (s, 2H, H7), 3.89 (d, JHP=14.4Hz, 2H, H1). 13C{1H} NMR (75.4 MHz, CDCl3): delta=155.9 (C6), 152.4 (d, JCP=7.0Hz, C2), 137.4 (C4), 132.3 (d, JCP=100.4Hz, C8), 131.8 (C11), 131.1 (d, JCP=9.5Hz, C9), 128.4 (d, JCP=11.9Hz, C10), 124.2 (d, JCP=3.2Hz, C5), 120.8 (C3), 46.5 (C7), 40.9 (d, JCP=64.0Hz, C1). IR (KBr, cm-1): nu = 3057, 2923, 1612, 1589, 1575, 1483, 1455, 1433, 1397, 1293, 1268, 1249, 1225, 1200 (nuP=O), 1161, 1118, 1084, 1066, 1024, 992, 963, 858, 827, 813, 753, 734, 714, 699, 690, 618, 575, 543, 519, 490, 452, 435, 410. HRMS (ESI): m/z (%) = 342.0826 (100) [M+H+]. C19H18NOPCl requires 342.0815; 364.0635 (40) [M+Na+]. C19H17NOPClNa requires 364.0634. Anal. Calc. for C19H17ClNOP: C, 66.77; H, 5.01; N, 4.10. Found: C, 66.66; H, 4.86; N, 3.50 %

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ouizem, Sabrina; Rosario Amorin, Daniel; Dickie, Diane A.; Cramer, Roger E.; Campana, Charles F.; Hay, Benjamin P.; Podair, Julien; Delmau, Laetitia H.; Paine, Robert T.; Polyhedron; vol. 97; (2015); p. 20 – 29;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

607-01-2, Ethyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Accurately weighed ethyl diphenylphosphine (123 muL, 0.6 mmol),4-bromobiphenyl (0.1399 g, 0.6 mmol),Potassium monohydrogen phosphate (0.4050 g, 3 mmol) was added to a 25 mL Schlenk reaction flask, followed by solvent toluene (2 mL).The reaction was carried out at 50 C for 8 h.After the reaction was completed, it was extracted with ethyl acetate/water.The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated.Using petroleum ether/ethyl acetate as the eluent,Separated by silica gel column,The yield of the product was 50%., 607-01-2

As the paragraph descriping shows that 607-01-2 is playing an increasingly important role.

Reference£º
Patent; Dalian University of Technology; Yu Xiaoqiang; Bao Ming; Feng Xiujuan; Yin Qing; (15 pag.)CN109970789; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

3-phenylpropyl-1-amine (344 ml;2.41 mmol) in 10 mL of toluene was added drop-wise to a mixtureof (2-(diphenylphosphino))-benzaldehyde (0.7 g; 2.41 mmol) andanhydrous magnesium sulfate (1.6 g) in toluene (10 mL). The reactionwas stirred under reflux for 3 h. Resulting in a light yellowmixture. After filtration a yellow oil was obtained upon eliminationof the solvent under reduced pressure. Twice the treatment withhexane (10 mL) resulted in a purification of the product, whichhowever did not crystallize. Yield: 97percent. 1H NMR (CDCl3, 298 K,300 MHz): d (ppm) 8.86 (d, J 4,65 Hz, 1H, HCN-), 7.98e7.94(m, 1H, aromatic), 7.38e7.04 (m, 17H, aromatic), 6,87-6,83 (m, 1H,aromatic), 3.48 (t, J 6.65 Hz, 2H, NCH2-), 2.44e2.39 (m, 2H,-CH2-Ph), 1.84e1.75 (m, 2H, -CH2-). 31P{1H} (CDCl3, 298 K):d (ppm)13.80. ESI-MS (CHCl3 after treatment of H2O2) m/z:424.2 [OPN3 H]., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wajda-Hermanowicz, Katarzyna; Kochel, Andrzej; Wrobel, Robert; Journal of Organometallic Chemistry; vol. 860; (2018); p. 30 – 48;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13360-92-4, Phenoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 20 Diphenyl[1-(morpholinosulfonylamino)ethyl]phosphine oxide STR28 When a mixture of equimolar quantities of phenyl diphenylphosphinite, acetaldehyde, and morpholinosulfonylamine in chlorobenzene is treated by the procedure used in the preceding experiment, the product is a white solid, mp 215-217 C., 31 P nmr (DMSO-d6) -30.9 ppm., 13360-92-4

13360-92-4 Phenoxydiphenylphosphine 11543680, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Monsanto Company; US4036913; (1977); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, To a stirred solution of CsF (63 mg, 0.42 mmol) in anhydrous acetonitrile 1 mL was consecutively added 2,5 dimethyl -(o-trimethyl silyl)phenyl triflate (25 mg, 0.077 mmol) and ethoxydiphenylphosphine (60 mg, 0.31 mmol). Reaction mixture was allowed to stir at room temperature (30 C) for 30 hrs. The reaction mixture’ was concentrated and directly loaded on silica gel column and purified by using solvent gradient of Pet. EthenEthyl Acetate (1 : 1) to yield a white solid phosphine oxide (19 mg, 81%). Reaction Time: 30 h; Rf: 0.3 (1 : 1 EtOAc:Pet Ether); White Solid; mp 157-159 C; 19.0 mg, 81 %; 1 H NMR (400 MHz, GDC13, TMS) delta 7.75-7.60 (m, 4H), 7.59-7.52 (m, 2H), 7.51-7.43 (m, 4H), 7.26-7.20 (m, 1H), 7.19-7.13 (m, 1H), 6.88 (d, J = 14.4 Hz, 1H), 2.37 (s, 3H), 2.21 (s, 3H); 13C NMR ( 100 MHz, CDCI3, TMS) 5 140.0 (d, J = 7.7 Hz), 134.7 (d, J = 13.1 Hz), 133.9 (d, J = 12.3 Hz), 132.9 (d, J = 103.3 Hz), 132.8 (d, J = 2.3 Hz), 13 .9 (d, J = 10.0 Hz), 131.8, 131.7 (d, J = 3.1 Hz), 130.4(d, J= 103.3 Hz), .128.5 (d, J = 11.6 Hz), 21.2 (d, J = 4.6 Hz), 21.0; 31P NMR ( 162 MHz, CDCI3) delta 31.7; HRMS-ESI (m/z) calcd (C20H19OP + H)+ : 307.1246 found: 307.1244.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The solutions of a (0.0256 g, 0.1 mmol) ofH2dz in 10 cm3 of methanol, (0.1 mmol, 0.0273 g) ofCoCl2.6H2O in a10 cm3 of methanol) and (0.0554 g,0.1 mmol of 1,1′-bis(diphenylphosphine) ferrocene(dppf) were mixed and refluxed at 55 oC for 2 h togive brown colored precipitate and the solutionswas filtered and finally it was dried in an openair. Yield= 76percent, d.p= 288¡ãC. Anal. Calc.percent for C47H41 Cl N4 P2 Co S Fe:C, 62.30; H, 4.56; N, 6.18,S, 3.54, Co, 6.50, Cl, 3.91. Found percent: C, 61.95; H,4.62; N, 6.48, S; 3.85, Co; 6.73,Cl, 4.01. 1H-NMR(d6-DMSO) delta:7.78(4H,d), 7.42(4H,t), 7.28 ? 7.38(mH), 11.61(1H). The Proposed GeometricalStructure shown in Figure 1.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Mohamad, Hikmat Ali; Oriental Journal of Chemistry; vol. 34; 4; (2018); p. 1919 – 1925;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, To a solution of complex Re1 (40 mg, 0.098 mmol) in hexane (1 mL), Ph2P(OEt) (25 mg, 0.109 mmol) was added. The reaction mixture was stirred for 2 h. The precipitate formed was filtered off and dried in oil-pump vacuum to yield 48 mg (77%) of product Re4 as light-yellow powder. Calculated for C29H26O3PRe, %: C, 54.45; H, 4.10. Found: C, 54.40; H, 4.12. IR (hexane), nu/cm-1: 1902s, 1835s (CO). 1H NMR (C6D6), delta: 0.89 (t, 3H, 3JHH = 7.0 Hz, OCH2CH3), 3.43 (dq, 2H, 3JHH ? 3JPH ? 6.4 Hz, POCH2CH3), 4.44 (s, 5H, Cp), 7.11-7.23 (Hpara Ph; Hmeta and Hpara PPh), 7.39 (dd, 2H, 3JHH = 7.6 Hz, Hmeta Ph), 8.02 (d, 2H, 3JHH = 7.9 Hz, Hortho PPh), 8.06 (d, 2H, 3JHH = 7.2 Hz, Hortho PPh), 8.37 (d, 2H, 3JHH = 7.7 Hz, Horhto Ph), 8.75 (d, 1?, 3JPH = 39.0 Hz, =CHPh). 31P{H} NMR (C6D6), delta: 32.28 (s, P+Ph2(OEt)).

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Utegenov, Kamil I.; Krivykh, Vasily V.; Chudin, Oleg S.; Smol’yakov, Alexander F.; Dolgushin, Fedor M.; Semeikin, Oleg V.; Shteltser, Nikolai A.; Ustynyuk, Nikolai A.; Journal of Organometallic Chemistry; vol. 867; (2018); p. 113 – 124;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Trisdimethylaminophosphine (1 mmol) was added to a solution of methyl-isatin (1 mmol) in dry toluene with stirring for 1-2 h at room temperature. After evaporation of the volatile material under reduced pressure, the residue was subjected to silica-gel column chromatography to give the isoindigo 6 as red crystals., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Arsanious, Mona Hizkial Nasr; Maigali, Soher Said; Synthetic Communications; vol. 44; 2; (2014); p. 202 – 214;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-1,2,4-triaz ol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of EA and n-hexane (EA:n-hexane=1:2 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E3 (44% yield; 73 mg). The reaction scheme for producing the complex E3 is represented as follows: The spectrum analysis for the complex E3 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=7.2 Hz, 1H), 8.05 (s, 1H), 7.84-7.89 (m, 4H), 7.52-7.56 (m, 3H), 7.46-7.50 (m, 4H), 7.17 (d, J=6.8 Hz, 1H), 6.97-6.79 (m, 2H), 6.78 (dd, J=2.2, 6 Hz, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.48 (s, 9H), 1.31 (s, 9H), 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.32, FAB-MS m/z 728.1 [M+1]+, 7650-91-1

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate