5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.
A solution prepared by dissolving 0.86 g (3.1 mmol) of diphenyl (2-toluyl) phosphine in 5 ml of chloroform was charged into a 30 mL eggplant flask equipped with a stirrer, cooled in an ice bath, and filtered dropwise. 6.1 g (62 mmol) of 34.5% aqueous hydrogen peroxide was dropped from the funnel and stirred for 40 minutes. After separating the organic layer with a separatory funnel, the aqueous layer was washed 5 times with 5 ml of chloroform. The obtained organic layer was dried over magnesium sulfate, and then chloroform was distilled off, followed by vacuum drying to obtain crude diphenyl (2-toluyl) phosphine oxide as a yellow solid. The obtained crude diphenyl (2-toluyl) phosphine oxide was dissolved in ethyl acetate / n-hexane and recrystallized and purified to give a white solid of diphenyl (2-toluyl) phosphine oxide.0. 91 g (3.1 mmol) were obtained.
As the paragraph descriping shows that 5931-53-3 is playing an increasingly important role.
Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate