With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
Triphenylphosphonium bromide 2b (16.81 g, 49.0 mmol), and xylene (50 mL) were added into flask A (250 mL) with an inlet connected to a nitrogen balloon. To flask B (500 mL, three-necked) with an inlet connected to the flask A, (2-diphenylphosphino)benzoic acid 2e (10.00 g, 32.6 mmol), and MTBE (200 mL) were added. The flask A was heated in an oil-bath at 130 ¡ãC, and the generated HBr1 was introduced through a glass tube into the flask B under stirring by purging nitrogen. After solid 2b was completely disappeared, the reaction mixture in the flask B was filtered,and the white solids were washed with MTBE (80 mL ¡Á 2) and hexane (60 mL ¡Á 3). The solids were collected and dried in vacuo to afford (2-carboxyphenyl)diphenylphosphonium bromide 2d (11.21 g) in 89percent yield., 17261-28-8
As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.
Reference£º
Article; Huang, Wenhua; Xu, Ning; Synthetic Communications; vol. 47; 22; (2017); p. 2133 – 2138;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate