With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5
An acetonitrile solution (5 mL) of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) was slowly added to a dichloromethane solution (5 mL) of cyclohexyldiphenylphosphine (0.027 g, 0.10 mmol) and compound 1 (0.040 g, 0.10 mmol). The resulting mixture was immediately turned from red to dark brown. After 1 h, the solvent was concentrated on an evaporator. The brown residue was purified by TLC (petroleum ether: CH2Cl2 = 4: 1) to give compound 2 (0.046 g, yield 72%) from the main red band. IR (KBr disc, cm-1): nuC?O 2044 (vs), 1983 (vs), 1973 (vs), 1925 (m). 1H NMR (500 MHz, CDCl3): 7.71 (s, 2H, PhH), 7.62 (s, 2H, PhH), 7.47, 7.45 (2s, 6H, PhH), 2.31 (s, 2H, CyH), 2.18 (s, 2H, CyH), 1.84 (s, 2H, SCH2), 1.70 (s, 1H, SCH), 1.39 (s, 2H, CyH), 1.28 (m, 2H, CyH), 1.14-1.03 (m, 3H, CyH), 0.79 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85% H3PO4): 65.14 (s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 216.18 (d, JP-C = 9 Hz, PFeCO), 215.94 (d, JP-C = 8.5 Hz, PFeCO), 210.45 (FeCO), 135.29 (d, JP-C = 33.9Hz, i-PhC), 133.40 (d, JP-C = 9.6Hz, o-PhC), 132.86 (d, JP-C = 10 Hz, o-PhC), 130.08 (s, p-PhC), 128.20 (t, JP-C = 8.9 Hz, m-PhC), 54.32 (SCH), 41.12 (SCH2), 40.95, 40.85, 28.90, 27.43, 27.35, 25.99 (CyC), 29.58 (CH2CH3), 14.05 (CH3) ppm. Anal. Calcd. for C27H29Fe2O5PS2: C, 50.65; H, 4.57. Found:C, 50.79; H, 4.34%.
The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Jiang, Zhong-Qing; Li, Yu-Long; Liu, Xing-Hai; Liu, Xu-Feng; Yan, Lin; Yang, Jun; Journal of Sulfur Chemistry; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate