Day: October 13, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4020-99-9,Methoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

As shown in Figure 1 Wittig reagent between methoxy benzyldiphenyloxy phosphate synthesis route.In a 1000 ml reaction flask, 108 g was added(0.5 mol) of diphenylmethoxyphosphine(Purity & gt; 99.5%) and 120 g (0.7 mol)M-methoxybenzyl chloride (content ? 99.2%),Stirring temperature conditions to 55 , and at this temperature for 8 hours, Paul finished cooling to 10 , directly into the next step reaction.

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Taicang Kastem New Material Co., Ltd; Li, Ruiqing; (5 pag.)CN105440075; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride., 12150-46-8

The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: To a well-stirred solution of compounds (2a-2b) (2mmol) in anhydrous toluene (15 mL) was added hexamethylphosphoroustriamide (2mmol). The mixture was heated under reflux for 12 h. Silica gel TLC indicated the completion of the reaction. The solvent was evaporated under reduced pressure, and the residue was purified on silica gel preparative TLC using ethyl acetate as eluent. A mixture of compounds (3a-3b) (1mmol), S8 (5 mmol) and anhydrous toluene (10mL) was refluxed for 4h, and then cooled. The sulfur excess was filtered off, and the solvent was removed under reduced pressure. Flash column chromatography on silica gelusing petroleum ether as eluant affords (4a-4b)., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Balti, Monaem; Efrit, Mohamed Lotfi; Journal of Sulfur Chemistry; vol. 37; 4; (2016); p. 466 – 475;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

1.453 g of 2-diphenylphosphine-biphenyl, 1.404 g of 2-iodoanisole, 122.5 mg of cymene dichloride dimer, and 78.7 mg of N-Ac-beta-alanine were added to the reactor. 1.536 g of cesium acetate and 2 mL of toluene, the reaction temperature was controlled at 120 ¡ã C for 18 hours, then cooled to room temperature, filtered through celite and distilled under reduced pressure to give 1.76 g of product.95percent.

13885-09-1, 13885-09-1 2-(Diphenylphosphino)biphenyl 12976978, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Hubei University; Liu Yuejin; Li Jiawei; Wang Liangneng; Zeng Minghua; (9 pag.)CN109400646; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5931-53-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5931-53-3,Diphenyl(o-tolyl)phosphine,as a common compound, the synthetic route is as follows.

A solution prepared by dissolving 0.86 g (3.1 mmol) of diphenyl (2-toluyl) phosphine in 5 ml of chloroform was charged into a 30 mL eggplant flask equipped with a stirrer, cooled in an ice bath, and filtered dropwise. 6.1 g (62 mmol) of 34.5% aqueous hydrogen peroxide was dropped from the funnel and stirred for 40 minutes. After separating the organic layer with a separatory funnel, the aqueous layer was washed 5 times with 5 ml of chloroform. The obtained organic layer was dried over magnesium sulfate, and then chloroform was distilled off, followed by vacuum drying to obtain crude diphenyl (2-toluyl) phosphine oxide as a yellow solid. The obtained crude diphenyl (2-toluyl) phosphine oxide was dissolved in ethyl acetate / n-hexane and recrystallized and purified to give a white solid of diphenyl (2-toluyl) phosphine oxide.0. 91 g (3.1 mmol) were obtained.

As the paragraph descriping shows that 5931-53-3 is playing an increasingly important role.

Reference£º
Patent; Tosoh Corporation; Tokyo University of Science; Kuramochi, Yusuke; Satake, Shoji; Hara, Oharu; (28 pag.)JP2019/142829; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

The experimental multi-tooth phosphine coordination silver complex double emitting dye synthesis method according to the following steps:1 mmol of multidentate phosphine ligand, 1 mmol of AgBr, 5 ml of DCM were mixed and reacted at 40 C. for 10 hours. The mixture was spin-dried and purified by column chromatography with DCM and PE to obtain a multidentate phosphine coordination silver complex.Wherein the ratio of multidentate phosphine ligand to AgBr is 1: 1.The volume ratio of DCM to PE in the mixed solvent of DCM and PE is 1:20.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Heilongjiang University; Xu Hui; Zhang Jing; Han Chunmiao; (47 pag.)CN106833010; (2017); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

As the paragraph descriping shows that 1608-26-0 is playing an increasingly important role.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

Triphenylphosphonium bromide 2b (16.81 g, 49.0 mmol), and xylene (50 mL) were added into flask A (250 mL) with an inlet connected to a nitrogen balloon. To flask B (500 mL, three-necked) with an inlet connected to the flask A, (2-diphenylphosphino)benzoic acid 2e (10.00 g, 32.6 mmol), and MTBE (200 mL) were added. The flask A was heated in an oil-bath at 130 ¡ãC, and the generated HBr1 was introduced through a glass tube into the flask B under stirring by purging nitrogen. After solid 2b was completely disappeared, the reaction mixture in the flask B was filtered,and the white solids were washed with MTBE (80 mL ¡Á 2) and hexane (60 mL ¡Á 3). The solids were collected and dried in vacuo to afford (2-carboxyphenyl)diphenylphosphonium bromide 2d (11.21 g) in 89percent yield., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Huang, Wenhua; Xu, Ning; Synthetic Communications; vol. 47; 22; (2017); p. 2133 – 2138;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, l-(trimethylsilyl)naphthalen-2-yl trifluoromethanesulfonate (25 mg, 0.071 mmol), Cesium Fluoride (60 mg, 0.395 mmol), Ethoxydiphenylphosphane (68 mg, 0.287 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf. 0.4 (1 :3 EtOAc:Pet Ether); Thick oil; 19.5 mg, 83 %; NMR (400 MHz, CDCI3, TMS) delta 8.28 ( d, J = 13.8 Hz, 1H), 7.95-7.84 (m, 3H), 7.79-7.40 (m, 13 H); 13C NMR (100 MHz, CDC13, TMS) delta 134.7 (d, J= 2.3 Hz), 134.0 (d, J= 9.3 Hz), 133.0, 132.3, 132.1 (d, J =10.0 Hz), 132.0 (d, J = 1.5 Hz), 131.3 (d, 7 = 243.5 Hz), 128.9, 128.5 (d, J = 12.3 Hz), 128.4, 128.2, 127.4 (d, J = 87.9 Hz), 126.8 (d, J= 10.8 Hz); 3IP NMR (162 MHz, CDC13) delta 29.3; HRMS-ESI (m/z) calcd (C22H17OP + H)+ : 329.1090 found: 329.1086; Known compound, Lit. Y.-L. Zhao, G.-J. Wu, Y. Li, L.-X. Gao, F.-S. Han, Chem. Eur. J. 2012, 18, 9622.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

An acetonitrile solution (5 mL) of Me3NO¡¤2H2O (0.011 g, 0.10 mmol) was slowly added to a dichloromethane solution (5 mL) of cyclohexyldiphenylphosphine (0.027 g, 0.10 mmol) and compound 1 (0.040 g, 0.10 mmol). The resulting mixture was immediately turned from red to dark brown. After 1 h, the solvent was concentrated on an evaporator. The brown residue was purified by TLC (petroleum ether: CH2Cl2 = 4: 1) to give compound 2 (0.046 g, yield 72%) from the main red band. IR (KBr disc, cm-1): nuC?O 2044 (vs), 1983 (vs), 1973 (vs), 1925 (m). 1H NMR (500 MHz, CDCl3): 7.71 (s, 2H, PhH), 7.62 (s, 2H, PhH), 7.47, 7.45 (2s, 6H, PhH), 2.31 (s, 2H, CyH), 2.18 (s, 2H, CyH), 1.84 (s, 2H, SCH2), 1.70 (s, 1H, SCH), 1.39 (s, 2H, CyH), 1.28 (m, 2H, CyH), 1.14-1.03 (m, 3H, CyH), 0.79 (s, 3H, CH3) ppm. 31P{1H} NMR (200 MHz, CDCl3, 85% H3PO4): 65.14 (s) ppm. 13C{1H} NMR (125 MHz, CDCl3): 216.18 (d, JP-C = 9 Hz, PFeCO), 215.94 (d, JP-C = 8.5 Hz, PFeCO), 210.45 (FeCO), 135.29 (d, JP-C = 33.9Hz, i-PhC), 133.40 (d, JP-C = 9.6Hz, o-PhC), 132.86 (d, JP-C = 10 Hz, o-PhC), 130.08 (s, p-PhC), 128.20 (t, JP-C = 8.9 Hz, m-PhC), 54.32 (SCH), 41.12 (SCH2), 40.95, 40.85, 28.90, 27.43, 27.35, 25.99 (CyC), 29.58 (CH2CH3), 14.05 (CH3) ppm. Anal. Calcd. for C27H29Fe2O5PS2: C, 50.65; H, 4.57. Found:C, 50.79; H, 4.34%.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jiang, Zhong-Qing; Li, Yu-Long; Liu, Xing-Hai; Liu, Xu-Feng; Yan, Lin; Yang, Jun; Journal of Sulfur Chemistry; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate