Day: October 12, 2020

1608-26-0, N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of (S)-3,3′-Dibenzyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol24 (0.42 g, 1.00 mmol) in toluene (5 mL) was added hexamethylphosphorous triamide (248 mg, 1.50 mmol) under nitrogen. The resulting mixture was stirred at 80 C for 17 h. The solvent was evaporated under reduced pressure to afford a gel-like product, which was further purified by column chromatography on silica gel (pretreated with 1% NEt3 in hexanes) using hexanes/EtOAc (19/1) as the eluent to give (R)-MPN-Lf (0.32 g, 65%) as a white solid., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chien, Chih-Wei; Shi, Ce; Lin, Chi-Feng; Ojima, Iwao; Tetrahedron; vol. 67; 35; (2011); p. 6513 – 6523;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

To a solution of P(3-Me-C6H4)3 (1.98 g, 6.50 mmol) in toluene (20 mL), a solution of 3c (1.51gm, 5.90 mmol) in toluene (10 mL) was added via cannula. After 4 hours, the clear yellow solution was evaporated to afford a yellow residue. The yellow residue was washed with a mixture of 1:3 toluene-hexanes (4 x 12 mL), yielding a yellow oil. The yellow oil was washed with ether (10 mL) to give white solid 8 (1.8 g, 60percent). 1H NMR (CDCl3): delta 7.71 (s, 1H, 6-CH of -C6H3SO3-), 7.68 (s, 3H, 2-CH of (3-CH3-C6H4)3P=NH-), 7.55 (m, 3H, 5-CH of (3-CH3-C6H4)3P=NH-), 7.32 (s, 3H, 4-CH and 6-CH of (3-CH3-C6H4)3P=NH-), 6.85 (d, J = 8.4, 1H, 4-CH of -C6H3SO3-), 6.39 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 3.90 (t, 2H, CH of CH2CH2CH3), 2.35 (s, 9H, 3-CH3 of (3-CH3-C6H4)3P=NH-), 2.19 (s, 3H, J = 6.8, 5-CH3 of – CH3C6H3SO3-), 1.52 (m, 2H, CH of CH2CH2CH3), 0.78 (t, 3H, J = 7.4, CH of CH2CH2CH3). 31P NMR (CDCl3): delta 2.7. 13C NMR (CDCl3): delta 148.9, 138.4 (d, JPC = 11.6), 134.6, 133.1 (d, JPC = 9.3), 132.5 (d, JPC = 3.1), 131.5 (d, JPC = 2.3), 130.5 (d, JPC = 10.0), 129.8 (d, JPC = 2.3), 128.4 (d, JPC = 13.2), 126.5 (d, JPC = 24), 124.6, 122.5 (d, JPC = 10.8), 71.1, 22.4, 21.5, 20.2, 10.1. Anal. Calcd for C31H34NO3PS: C, 70.03; H, 6.45; N, 2.63. Found: C, 69.89; H, 6.32; N, 2.52., 6224-63-1

6224-63-1 Tri-m-tolylphosphine 80362, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 4-(tert-butyl)-2-(3-(tert-butyl)-1H-pyrazol-5-yl)pyridine (59 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of dichloromethane and n-hexane (dichloromethane:hexane=1:1 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a light yellow crystalline product, referred to as complex E2 (59.9% yield; 98.9 mg). The reaction scheme for producing the complex E2 is represented as follows: The spectrum analysis for the complex E2 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 9.05 (d, J=7.6 Hz, 1H), 7.86-7.91 (m, 3H), 7.62 (d, J=2.0 Hz, 1H), 7.46-7.54 (m, 5H), 7.26-7.31 (m, 2H), 7.17 (d, J=7.0 Hz, 1H), 6.98-7.11 (m, 4H), 6.60 (s, 1H), 3.80 (d, J=11.4 Hz, 2H), 1.44 (s, 9H), 1.28 (s, 9H) ppm, 31P NMR (200 MHz, CD2Cl2, 298 K) delta 36.68 ppm, FAB-MS m/z 727.7 [M+1]+

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Into a round bottom flask was added (dichloroiodo)benzene (2, 0.15 mmol, 1.02 equiv), DCM (0.25 mL, 0.6M), and to this was added excess ethanol (0.1 mL, 10 equiv), followed by the secondary phosphine oxide (0.15 mmol, 1.0 equiv,). The reaction mixture was stirred at room temperature for the indicated length of time, then concentrated in vacuo and purified by column chromatography., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Eljo, Jasmin; Murphy, Graham K.; Tetrahedron Letters; vol. 59; 31; (2018); p. 2965 – 2969;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.

Pt(tht)2Cl2 (synthesized according to a method disclosed in J. Chem. Soc., Dalton Trans. 1980, 888-894; 100 mg, 1 eq, ?tht? represents tetrahydrothiophene), benzyldiphenylphosphine purchased from Alfa Aesar (68 mg, 1.1 eq), and sodium acetate (94 mg, 5 eq) were added in a 50 mL round-bottomed flask, and degassed xylene (purchased from ECHOChemical; Product no: XA2101-000000-72EC; 6 mL) was then added therein with mixing to obtain a mixture, followed by heating to 100 C. and reacting for 12 hours. The mixture was then cooled to room temperature, and a precursor solution (PS1) of a phosphorescent four-coordinated platinum (II) complex was obtained. 3-(4-(tert-butyl)pyridin-2-yl)-7,8,8-trimethyl-4,5,6,7-tetrahydro-2H-4,7-methanoindazole (70 mg, 1 eq) was added into the PS1 obtained from Synthesis Example 1 to obtain a mixture, and the mixture was heated to 100 C. and reacted for 6 hours, followed by cooling to room temperature and removing the solvent. Silica-gel column chromatography was conducted to purify the mixture using an eluent of ethyl acetate (hereinafter referred as EA) and n-hexane (EA:n-hexane=1:3 (by volume)). Recrystallization was then conducted using dichloromethane/n-hexane so as to obtain a white crystalline product, referred to as complex E1 (77.4% yield; 137 mg). The reaction scheme for producing the complex E1 is represented as follows: The spectrum analysis for the complex E1 is: 1H NMR (400 MHz, CD2Cl2, 298 K) delta 8.97 (d, J=8.1 Hz, 1H), 7.84 (dd, J=10.4, 18.3 Hz, 4H), 7.38-7.51 (m, 8H), 7.06-7.07 (m, 2H), 6.94 (t, J=7.2 Hz, 1H), 6.47 (dd, J=1.8, 6 Hz, 1H), 3.73 (d, J=11.2 Hz, 2H), 2.97 (d, J=3.7 Hz, 1H), 2.08-2.14 (m, 1H), 1.80-1.86 (m, 1H), 1.43-1.47 (m, 1H), 1.41 (s, 3H), 1.25 (s, 9H), 0.97 (s, 3H), 0.84-0.88 (m, 1H), 0.81 (s, 3H) ppm, 31P NMR (200 MHz, CDCl3, 298 K) delta 36.38 ppm, FAB-MS m/z 779.7 [M+1]+, 7650-91-1

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; National Tsing Hua University; Chi, Yun; Huang, Li-Min; US8722885; (2014); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: The synthesis is similar to 2, with PPh3 being replaced by dppf(1.1 g, 2.0 mmol). The residue was purified by column chromatographyon silica gel (eluent: CH2Cl2/CH3OH, 30:1, V/V) to give abrown-yellow solid. Yield: 0.75 g, 72percent. 1H NMR (500 MHz, CDCl3)d 9.18 (d, J 8.2 Hz, 2H, ePhH), 8.63 (d, J 8.5 Hz, 2H, ePhH), 8.08(d, J 8.3 Hz, 2H, ePhH), 7.73e7.60 (m, 10H, ePhH), 7.56 (td, J 7.3,1.2 Hz, 4H, ePhH), 7.49e7.40 (m, 8H, ePhH), 6.29 (d, J 8.4 Hz, 2H,ePhH), 4.49 (s, 4H, eCpH), 4.20 (dd, J 8.2, 6.2 Hz, 8H, eCH2CH2e,eCpH), 1.73 (dt, J 15.2, 7.6 Hz, 4H, eCH2CH2e), 1.52e1.42 (m, 4H,eCH2CH2e), 0.99 (t, J 7.4 Hz, 6H, eCH2CH3). 13C NMR (125 MHz,Scheme 1.CDCl3) d 165.15, 164.40, 157.03, 133.29, 132.50, 131.90, 131.82, 131.31,131.17, 130.58, 129.82, 129.42, 129.23, 128.98, 128.91, 128.81, 124.08,122.48, 115.10, 114.99, 109.74, 74.39, 39.87, 30.39, 29.68, 20.46,13.90. 31P NMR (200 MHz, CDCl3) d 9.40. MS calcd for C66H56Fe-N4O5P2Na [MNa]: 1109.31, found: 1109.4., 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Xu, Shou De; Fang, Cheng Hui; Tian, Guang Xuan; Chen, Yi; Dou, Ye Hong; Kou, Jun Feng; Wu, Xiang Hua; Journal of Molecular Structure; vol. 1102; (2015); p. 197 – 202;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of CuI (0.019 g, 0.1 mmol) in CH3CN(5 mL) wasadded to a stirred solution of 1,10-phenanthroline (0.018 g,0.1 mmol) and 2-(Dpp)bp (0.034 g, 0.1 mmol) in EtOAc(5 mL). The mixture was stirred for 5 min and then the precipitatewas filtered off. The resultant clear solution was setaside for evaporation in air. Orange block crystals of complex1 were obtained after 1 day and red crystals of complex2 were obtained the next day. These two different productswere separated manually under a microscope. Yield: 20.0 mg(28.2percent, based on Cu) for 1 and 24.4 mg (27.1percent, based onCu) for 2. Anal. Calc. for 1 C36H27N2P1Cu1I1:C, 60.98; H,3.81; N, 3.95. Found (percent): C, 61.04; H, 3.81; N, 3.88. IR(KBr pellet, cm?1): 3446sh, 3004s, 1789m, 1639m, 1550s,1448m, 1209w, 1120m, 716m; for 2 C36H27N2P1Cu2I2:C,48.07; H, 3.03; N, 3.12. Found (percent): C, 48.14; H, 3.04; N,3.04. IR (KBr pellet, cm?1): 3522sh, 3004s, 1639w, 1461m,1221s, 930s, 868s.

13885-09-1, 13885-09-1 2-(Diphenylphosphino)biphenyl 12976978, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Di; Chai, Wen-Xiang; Song, Li; Transition Metal Chemistry; vol. 43; 6; (2018); p. 517 – 527;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DPPF (55 mg, 0.1 mmol) was added to a rapidly stirred, 10 mlCH2Cl2 suspension of RuCl2(PPh3)3 (96 mg, 0.1 mmol). A colorchange from purple-black to red was observed within a few minutes.The solutionwas stirred for 30 min, then a CH2Cl2 solution of2-aminopyridine (9.4 mg, 0.1 mmol) was added, giving an immediatecolor change to yellow-green. After a further 30 min, thesolvent was removed in vacuo and 5ml of diethyl ether (Et2O) wereadded. The yellow product was filtered off, washed twice withether (2 5 ml), and then dried under vacuum.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ge, Sai; Zhang, Jin; Zhao, Jianguo; Ulhaq, Imran; Ma, Guibin; McDonald, Robert; Journal of Organometallic Chemistry; vol. 879; (2019); p. 7 – 14;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, EXAMPLE FORTY-THREE: Synthesis of BrettPhosPdPhBr (17); In a nitrogen filled glovebox, a solution of BrettPhos (1, 23.6 mg, 44 mumol), bromobenzene (30 muL) and THF (2 mL) was added to solid (COD)Pd(CH2SiPhMe2)2 (20.4 mg, 40 mumol) (COD = 1,5-cyclooctadiene) in an oven-dried 20 mL vial. (The THF used in this experiment was prepared as escribed in the general procedures set forth in Example 7, then sparged with N2 for 30 min and stored over activated 3 A molecular sieves in a glovebox prior to use.) Pan, Y.; Young, G. B. J Organomet. Chem. 1999, 577, 257 ‘. The vial was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (8 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 17 (24 mg, 75%) as light-yellow needles as a THF mono-solvate: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.26-7.29 (m, 2H – minor), 7.00-7.06 (m, major and minor), 6.82- 6.92 (m, major and minor), 6.75-6.79 (m, IH – minor, IH – major), 4.33 (s, 3H – minor), 3.79 (s, 3H -major), 3.59 (s, 3H – minor), 3.33 (s, 3H – major), 3.00-3.08 (m, IH – major), 2.88-2.92 (m, IH – major), 2.72-2.82 (m, 2H – major), 2.46-2.53 (m, 2H – major), 2.32- 2.37 (m, 2H -minor), 1.50-1.90 (m, major and minor), 1.05-1.45 (m), 0.75-0.90 (m, 12H – major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 44.9 (minor), 36.9 (major).

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: A degassed dichloromethane (25.0?mL) solution of [RuCl2(PPh3)3] (96?mg; 0.10?mmol) and dppf (60.0?mg; 0.11?mmol), in a Schlenk flask, was stirred for 30?min followed by the addition of 0.10?mmol of the polypyridyl ligand. After 30?min of stirring the resulting solution was concentrated until ca. 5?mL and addition of 10?mL of diethyl ether afforded a solid, which was collected by filtration, washed with diethyl ether and dried under vacuum.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Davila-Rodriguez, Maria?Jose; Barolli, Joao Paulo; de Oliveira, Katia Mara; Colina-Vegas, Legna; da Silva Miranda, Fabio; Castellano, Eduardo Ernesto; Von Poelhsitz, Gustavo; Batista, Alzir Azevedo; Archives of Biochemistry and Biophysics; vol. 660; (2018); p. 156 – 167;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate