With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.
Weigh 0.2 mmol of (E)-1,3-diphenylpropene, 0.3 mmol of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone into a 15 mL pressure-resistant reaction tube and add magnetic stirring. The mixture was reacted with 2 mL of nitromethane at room temperature for 5 min, monitored by TLC, and then reacted with 0.4 mmol of bis(naphthalen-1-yl)phosphine oxide for 6 h. After completion of the reaction, it was extracted with 20 ml of sodium sulfite solution, 10 mL of ethyl acetate, dried over anhydrous sodium sulfate at 20 C for 10 minutes and filtered, and finally distilled under reduced pressure at -0.09 MPa at 40 C to remove organics. The product (E)-(1,3-diphenylallyl)bis(naphthalen-1-yl)phosphine oxide was obtained as a solvent in a yield of 96%., 13440-07-8
As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.
Reference£º
Patent; Guangdong University of Technology; Wen Chunxiao; Chen Qian; Wang Xiaofeng; Yu Guodian; Huo Yanping; Zhang Kun; (15 pag.)CN108774263; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate