Day: October 9, 2020

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.12 g,0.5 mmol) and POP (0.64 g, 1.2 mmol) reacted in CH3CN (5 mL) at 50Cfor 12 h. The resulting mixture was filtered through a plug of Celite andconcentrated to ca. 1 mL. Addition of Et2O (10 ml) to the filtrate affordeda pale yellow precipitate, which was collected and washed withEt2O. And the product was recrystallized with ethanol., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Wang, Jinglan; Chen, Hongyun; Xu, Shengxian; Su, Qingzhi; Zhao, Feng; He, Haifeng; Journal of Photochemistry and Photobiology A: Chemistry; vol. 387; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5, The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

Solid silver thiocyanate (0.0478 g, 0.29 mmol) was added to the solution of cyclohexyldiphenylphosphine(0.3031 g, 1.13 mmol) in acetonitrile (100 mL). The reaction mixture was heatedunder reux for 16 h. The solution was ltered hot and the solvent was reduced to ~10 mL by means of evaporation. The solution was transferred to a small vial and it was left to crystallizefrom which small white cubic crystals were isolated (0.3002 g, 84%), m.p. 173-176 C.Anal. Calcd for C55H63AgNSP3: C, 68.04; H, 6.54; N, 1.44; S, 3.30%. Found: C, 68.35; H, 6.56; N,1.39; S, 3.37%. Solid FTIR (nu, in cm-1): 3047(w) nu(C-H)aromatic; 2934, 2851(m) nuasym(C-H); 2360,2341(w); 2050(m) nu(SCN); 1479, 1461, 1446, 1432(m) nu(C=C)aromatic; 1328, 1309; 1268; 1193,1182, 1155; 1096(m) nu(P-C); 1071, 1024, 998(s) delta(C-H); 916(w); 885, 851, 741, 732 697(m)delta(C-H)aromatic. 1H NMR (400 MHz, CDCl3) (delta, in ppm): 1.27 (m, 14H, cyclohexyl), 1.67 (m, 14H,aromatic); 2.30 (d, 3J(H-H) = 8.0 Hz, 3H, H1); 7.30 (m, 17H, H-aromatic), 7.44 (t, 3J(H-H) = 8.0 Hz,11H, H-aromatic). 13C{H} NMR (100 MHz, CDCl3) (delta, in ppm): 25.94 (C4, cyclohexyl); 26.75 (d,1J(P-C) = 12.5 Hz, C1, cyclohexyl); 29.30 (d, 2J(P-C) = 10.4 Hz, C2, cyclohexyl); 35.61 (C3,cyclohexyl); 128.60 (d, 2J(P-C) = 8.3 Hz, ortho C, phenyl); 129.606 (para C, phenyl); 133.16 (d,3J(P-C) = 5.5 Hz, meta C, phenyl); 133.67 (d, 1J(P-C) = 16.3 Hz, ipso C, phenyl). 31P{H} NMR(161 MHz, CDCl3) (delta, in ppm): 9.32. 1H NMR (400 MHz, (CD3)2SO) (delta, in ppm): 1.14 (m, 14H,cyclohexyl), 1.59 (d, 3J(H-H) = 10.8 Hz, 3H, H1); 7.40 (m, 17H, H-aromatic), 7.59 (t, 2J(H-H) = 8.0 Hz, 11H, H-aromatic). 13C{H} NMR (100 MHz, (CD3)2SO) (delta, in ppm): 25.46 (C4,cyclohexyl); 25.81 (d, 1J(P-C) = 12.7, C1, cyclohexyl); 28.74 (d, 2J(P-C)=10.9, C2, cyclohexyl);33.97 (d, 3J(P-C) = 8.4 Hz, C3, cyclohexyl); 128.60 (d, 2J(P-C) = 8.6 Hz, meta C, phenyl); 129.64(para C, phenyl); 132.96 (d, 3J(P-C) = 13.7 Hz, ortho C, phenyl); 133.47 (d, 1J(P-C) = 16.6, ipsoC, phenyl). 31P{H} NMR (161 MHz, (CD3)2SO) (delta, in ppm): 9.04.

The synthetic route of 6372-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Potgieter, Kariska; Engelbrecht, Zelinda; Naganagowda, Gadada; Cronje, Marianne J.; Meijboom, Reinout; Journal of Coordination Chemistry; vol. 70; 15; (2017); p. 2644 – 2658;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

DCM-OH was obtained following the previous method [48], andthen DCM-P was synthesized as outlined in Scheme 2. DCM-OH (50 mg,0.16 mmol) and 2-(diphenylphosphino)benzoic acid (161.7 mg,0.528 mmol) were dissolved in dichloromethane, then 4-(dimethylamino)-pyridinium-4-toluene sulfonate (141.3 mg, 0.48 mmol) and N,N?-diisopropylcarbodiimide (60.6 mg, 0.48 mmol) were added. The reactionsystem was stirred at room temperature for 5 h under argon protection.After the reaction was over, the mixture was extracted withdichloromethane for 3 times. The organic layer was combined and driedwith anhydrous Na2SO4, and then the solvent was evaporated in vacuo.The residual was purified by silica gel chromatography with EA/PE toget the desired product DCM-P (40 mg, 0.067 mmol), and the yield was42%. 1H NMR (400 MHz, d6-DMSO, ppm): delta 8.74 (d, J=8.1 Hz, 1H), delta8.25 (dd, J1=8.1 Hz, J2=4.0 Hz, 1H), delta 7.96-7.92 (m, 1H), delta 7.79 (d,J=12.1 Hz, 3H), delta 7.74 (s, 1H), delta 7.65-7.59 (m, 3H), delta 7.54 (d,J=16.2 Hz, 2H), delta 7.42-7.40 (m, 5H), delta 7.25-7.21 (m, 4H), delta 7.09 (d,J=8.1 Hz, 2H), delta 7.06 (d, J=8.1 Hz, 1H), delta 6.94-6.90 (m, 1H); 13CNMR (100 MHz, d6-DMSO, ppm): delta 170.79, 165.10, 158.40, 153.50,152.52, 152.04, 140.78, 140.50, 137.91, 137.65, 137.53, 135.98,134.13, 133.92, 133.41, 131.90, 131.59, 129.81, 129.51, 129.30,129.23, 126.70, 125.16, 122.84, 122.80, 120.47, 119.57, 117.58,116.23, 61.05, 60.21; HRMS (ESI, m/z): [M + H]+ calcd forC39H26N2O3P: 601.1675, Found: 601.1676 (Figure S1)., 17261-28-8

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Tianlin; Chai, Yun; Chen, Shuhan; Yang, Guichun; Lu, Cuifen; Nie, Junqi; Ma, Chao; Chen, Zuxing; Sun, Qi; Zhang, Yuexing; Ren, Jun; Wang, Feiyi; Zhu, Wei-Hong; Dyes and Pigments; vol. 166; (2019); p. 260 – 265;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of complex 1 (0.245 g, 0.5 mmol) in MeCN (15 mL) was added the decarbonylation reagent Me3NO¡¤2H2O (0.056 g, 0.5 mmol). The mixture was stirred at room temperature for 10 min and then PPh3 (0.131 g, 0.5 mmol) was added. The resulting mixture was stirred for additional 2 h to give a dark red solution. Solvents were removed under vacuum and the residue was subjected to TLC using CH2Cl2/petroleum ether (v/v = 1:20) as the eluent. From the main red band, complex 2 (0.152 g, 42percent) was obtained as a dark red solid.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Yu-Long; He, Jiao; Wei, Juan; Wei, Jian; Mu, Chao; Wu, Yu; Xie, Bin; Zou, Li-Ke; Wang, Zheng; Wu, Mei-Li; Li, Han-Min; Gao, Fan; Zhao, Pei-Hua; Polyhedron; vol. 137; (2017); p. 325 – 331;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

The same general procedure was adopted for the synthesis of all the complexes. The lanthanide chloride and tricyclohexylphosphine oxide were dissolved in hot ethanol. Heating was continued for 1h and the solution was allowed to slowly evaporate at room temperature during which time crystalline material formed. The crystals were filtered, washed with cold ethanol and dried at the pump.

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 67; (2014); p. 368 – 372;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6224-63-1, Tri-m-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78percent).2

6224-63-1, The synthetic route of 6224-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below., 13689-19-5

The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, Thus, crotonaldehyde was treated with HCN in the presence of an (R)-oxynitrilase readily obtained from grinding and scouring of bitter almonds,18 which gave the (R)-cyanohydrin with high levels of enantioselectivity (>96percent ee).19 Subjecting to the conditions of a Pinner reaction furnished the ethyl ester 20 (Scheme 6).20 The reduction with lithium aluminum hydride led to diol 21 and subsequent silylation furnished the silylether 22 on a multigram scale.21 Applying the standard Steglich esterification protocol22 with ortho-diphenylphosphanylbenzoic acid (o-DPPBA)23 provided o-DPPB-ester (R)-(+)-6 quantitatively. Crystallization of this product improved the enantiopurity to greater than 99percent ee. In order to obtain the requested (S)-enantiomer of 6 one could apply a corresponding (S)-oxynitrilase. However, such enzymes are far more difficult to access.24 Hence, we looked at a Mitsunobu inversion protocol, which ideally would use o-DPPBA itself as the nucleophile.25 Since o-DPPBA is both a carboxylic acid and a phosphine we expected this to be a non trivial reaction because the reagent triphenylphosphine as well as o-DPPBA may react with the azodicarboxylate electrophile. Interestingly, we observed a clean Mitsunobu reaction of the allylic alcohol 22 with o-DPPBA to furnish the corresponding (S)-(-)-enantiomer of o-DPPB-ester 6 in good yield (81percent). After recrystallization (S)-(-)-6 was obtained in >99percent enantiopurity.

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Albert-Ludwigs-Universitat Freiburg; US2011/282075; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,Add in 50 mL Schlenk bottle(SO3Na) 3-R6, 4.73 mmol of [n_C16H33 (EO) 16N + H = C (N (CH3) 2) 2] [CH3SO3-] and 20 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours, filtered and the filtrate was removed under reduced pressure to give an orange yellow viscous liquid in 94% yield.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate