Month: September 2020

819867-21-5,819867-21-5, Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-([1,2,4]triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and 3-bromo-[1,2,4]triazolo[4,3-b]pyridine (10.3 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 80 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity, yielding the desired product (10.2 g, 37%).

819867-21-5 Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 67475893, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reactions were run in a CEM Corp. MARS microwave fitted with a fiber optic temperature probe and a port on top for a reflux condenser.1 mmol of Mo(CO)6 and dppe (0.425 g, 1.1 mmol) were combined with 20 mL of 1-propanol in a two-neck 100 mL RB flask. To this mixture was added NaBH4 (0.128 g, 3.3 mmol). The flaskwas placed in themicrowave and a reflux condenser attached through a hole in the top of the microwave. The mixture was sparged with nitrogen. The mixture was heated under nitrogen at 400 W for 1.5 min to reach reflux temperature. Once the reflux temperature was reached the microwave power was reduced and the temperature maintained for 18 min. The mixture was cooled to room temperature and 2?4 mL of water was added to the reaction to dissolve excess NaBH4 and promote product precipitation. The reaction was cooled ?10 ¡ãC for several hours. The light yellow complex was filtered in air and washed with 2¡Á5 mL of petroleum ether/diethyl ether(1:1) mixture resulting in 580 mg of Mo(CO)4dppe after drying, a 95percent yield.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Birdwhistell, Kurt R.; Schulz, Brian E.; Dizon, Paula M.; Inorganic Chemistry Communications; vol. 26; (2012); p. 69 – 71;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, General procedure: The general procedure is followed using 259 mg (0.50 mmol) of 33 [(cinnamyl)PdCl]2, 257 mg (1.00 mmol) of 22 AgOTf, 537 mg (1.00 mmol) of BrettPhos in anhydrous 2-MeTHF to give 884 mg (0.97 mmol, 97%) of the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3, delta): complex spectrum-see FIG. 5. 13C NMR (100 MHz, CDCl3, delta): complex spectrum-see FIG. 6. 31P NMR (162 MHz, CDCl3, delta): 57.6, 39.5. 19F NMR (376 MHz, CDCl3, delta): -78.1 (s, 3F). Anal. Calcd. for C45H62F3O5PPdS: C, 59.43; H, 6.87. Found: C, 59.26; H, 6.68.

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Johnson Matthey Public Limited Company; Colacot, Thomas; Jon Deangelis, Andrew; (66 pag.)US9777030; (2017); B2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4020-99-9, Methoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

As shown in Figure 1 between the Wittig reagent methoxy benzyl diphenyl phosphorusoxychloride synthetic route.In 1000 ml by adding reaction bottle 108g (0.5mol) diphenyl methoxy phosphorus (? 99.5% purity) and 86g (0.5mol) (content ? 99.2%) making between, under stirring condition temperature to 55 C, and at this temperature thermal insulation 8 hours, heat insulating end cooling to 10 C, directly enters the reaction of the next.

4020-99-9, 4020-99-9 Methoxydiphenylphosphine 77636, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Taicang Kastem New Material Co., Ltd; Li, Ruiqing; (5 pag.)CN105503951; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.

TfOCH2CF2H (0.257 g, 1.2 mmol) was reacted with tris (m-tolyl) phosphine (0.365 g, 1.2 mmol) The reaction was stirred at 120 ¡ã C for 6 h, The resulting solid was then treated with ether, Toluene, N-hexane or petroleum ether, filter, And then pump dry, The product (E)-[(3-CH3C6H4)3PCHCHP(3-CH3C6H4)3][OTf]2 (white solid, 0.447g,0.48mmol) Yield: 80percent., 6224-63-1

As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.

Reference£º
Patent; Wuhan University of Technology; Zhang, Chengpan; Wang, Shimeng; Dongh, Tao; Han, Jiabin; (10 pag.)CN105017320; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

240417-00-9, 2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

CH2Cl2 (25 ml) was added to a Schlenk flask containing the 2-(N,N-dimethlamino)-2′-(diphenylphosphino)biphenyl (2.00 g, 5.2 mmol) and (DME)NiBr2 (1.30 g, 4.2 mmol) in a dry box. A green solution formed immediately upon mixing. This solution was stirred for 20 hours. Then, it was filtered and recrystallized from CH2Cl2/pentane. The product was washed three times with an additional 15 ml of pentane and dried for 1 hour under vacuum. A green powder was isolated in 69.3% yield. The product was soluble in CH2Cl2. 1H NMR indicates that it is paramagnetic. Anal. Calcd for (C26H24NPBr2Ni) : C, 52.03% ; H, 4.08% ; N, 2.33% ; P, 5.16%. Found: C, 1.20% ; H, 4.24% ; N, 2.14% ; P, 5.29%.

240417-00-9, As the paragraph descriping shows that 240417-00-9 is playing an increasingly important role.

Reference£º
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2004/37837; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,6-Bis(chloromethyl)-3-hydroxypyridine hydrochloride (5) (0.20 g, 0.88 mmol) was added to a solution of tris(2-thienyl)phosphine (0.98 g, 3.50 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 48 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloro- form and washed with water. The aqueous filtrate was dried in vacuo, and recrystallized from acetone. The yield was 0.10 g (15%), a white crystalline compound, m.p. 176-178 C. 1H NMR (DMSO-d6), d: 5.00 (d, 2 H, CH2P, J = 15.3 Hz); 5.11 (d, 2 H, CH2P, J = 15.7 Hz); 7.10, 7.34 (AB-system, 2 H, PyH, J = 8.4 Hz); 7.47-7.49 (m, 3 H, P(2-thien)3); 7.51-7.53 (m, 3 H, P(2-thien)3); 7.89 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1= 8.3 Hz, J2= 3.6 Hz); 8.47-8.50 (m, 6 H, P(2-thien)3); 11.33 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 20.92 (s, CH2P); 25.93 (d, CH2P, J = 54.4 Hz); 119.25 (d, Cthien, J = 86.5 Hz); 123.89 (s, CPyr); 124.71 (s, CPyr); 129.64 (d, Cthien, J = 13.4 Hz); 131.00 (d, Cthien, J = 10.1 Hz); 133.74 (d, Cthien, J = 10.2 Hz); 135.23 (d, Cthien, J = 2.1 Hz); 137.02 (s, CPyr); 138.01 (CPyr); 139.45 (d, Cthien, J = 12.7 Hz); 153.09 (t, CPyr, J = 5.1 Hz). 31P NMR (DMSO-d6), d: 4.07; 4.31. HRMS, found: m/z 340.4863 [M – 3 Cl – H]2+. C31H26NOP2S6Cl2. Calculat- ed: [M – 3 Cl – H] = 340.4863., 24171-89-9

As the paragraph descriping shows that 24171-89-9 is playing an increasingly important role.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

The heteroleptic nickel, palladium and platinum complexes (1?10) were prepared according to the general procedure shown in Scheme 1. To a stirring 15 ml methanolic solution of the ligand K2(p-CH3C6H4SO2N=CS2)¡¤2H2O (0.18 g, 0.5 mmol), K2(p-ClC6H4SO2N=CS2)¡¤2H2O (0.19 g, 0.5 mmol), K2(p-BrC6H4SO2N=CS2)¡¤2H2O (0.21 g, 0.5 mmol) or K2C2H5OCO(CN)CCS2 (0.13 g, 0.5 mmol) a 10ml aqueous solution of NiCl2¡¤6H2O (0.12 g, 0.5 mmol), K2PdCl4 (0.163 g, 0.5 mmol) or K2PtCl4 (0.21 g, 0.5 mmol) was added and in each case the reaction mixture was stirred for half an hour to get a clear solution. To this 25 ml solution was added a 10 ml dichloromethane solution of 1,1?-bis(diphenylphosphino)ferrocene (0.28 g, 0.5 mmol) with vigorous stirring and then further stirred for 12 h in the case of Ni and 24 h for Pd and Pt complexes. The volume of the reaction mixtures were reduced to 15 ml on rotary evaporator and the solid products thus obtained were filtered off and washed with H2O?CH3OH (40:60 v/v) and dried in vacuo over calcium chloride., 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Singh, Santosh K.; Chauhan, Ratna; Diwan, Kiran; Drew, Michael G.B.; Bahadur, Lal; Singh, Nanhai; Journal of Organometallic Chemistry; vol. 745-746; (2013); p. 190 – 200;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-18-7, Example 38A (4-Nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 300 mg (1.97 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine, 326 mg (2.36 mmol) of 4-nitroaniline, 90 mg (0.10 mmol) of tris(dibenzylideneacetone)dipalladium, 51 mg (0.1 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 598 mg (4.33 mmol) of potassium carbonate in 3.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. After cooling to RT, the reaction mixture is filtered through kieselguhr, the kieselguhr is washed with ethyl acetate/methanol 100:5 and the solvent of the filtrate is removed. The residue is taken up in dichloromethane. The crystallized solid is filtered off, washed with dichloromethane and dried. Mother liquor and filtrate are combined and concentrated under reduced pressure. Purification of the residue by preparative HPLC yields the target product. Yield: 340 mg (78% of theory) LC-MS (Method 3): Rt=1.38 min. MS (ESI pos.): m/z=255 (M+H)+. 1H-NMR (DMSO d6, 300 MHz): delta=6.48-6.58 (m, 1H), 6.97 (d, 1H), 7.28-7.42 (m, 3H), 8.08 (d, 1H), 8.19 (d, 2H), 9.55 (s, 1H), 11.62 (s, 1H).

The synthetic route of 564483-18-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

Similar proceduredescribed for 2a was used in the synthesis of 5a using dppbz instead of dppe to obtain a pale yellow solid. Yield:70%. 31P-NMR (121.42 MHz, 298 K, CDCl3): 62.3 ppm(d, 1J(Rh-P) = 134 Hz). 1H-NMR (300 MHz, 298 K,CDCl3): 7.59-6.83 (m, Ph ? P – C6H4 – P). ESI-MS(?)m/z: 995.0 ([M-3 Ph]?, calc.: 994.9). IR (KBr, cm-1):1973 versus, m(C:O).

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Arcau, Julia; Ferrer, Montserrat; Aguilo, Elisabet; Rodriguez, Laura; Transition Metal Chemistry; vol. 42; 1; (2017); p. 57 – 67;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate