Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add in the reaction bottle4-phenylbutyne (0.065 g, 0.5 mmol), dinaphthyl phosphorus (0.30 g, 1 mmol),Cu(SCN)2 (0.0179 g, 0.1 mmol), tert-butyl peroxide (0.30 mL, 2 mmol) and water (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 85%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4559-70-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: Under an argon atmosphere, the carbonyl compounds (0.24 mmol, 1.2 eq), TsNHNH2 (0.252 mmol, 1.26 eq) and anhydrous dioxane (2.0 mL) were successively added to a flame-dried Schlenk flask. The reaction was heated at 60 ?C with stirring for 30 minutes. After the solution cooled down to room temperature diphenyl phosphine oxide 1a (0.20 mmol, 1.0 eq), K2CO3 (0.60 mmol, 3.0 eq), and CuI (0.02 mmol, 10 mol %) were sequentially added to the system. The mixture was stirred to reflux. When the reaction was considered complete, as determined by TLC analysis, the reaction mixture was cooled to room temperature. Water was added to the mixture and extracted with ethyl acetate twice. The combined organic phase was washed with brine and dried over Na2SO4. The concentrated residue was purified by column chromatography over silica gel using petroleum ether/ethyl acetate (1:1) as eluent to get the product.

The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Zi-Sheng; Zhou, Zhao-Zhao; Hua, Hui-Liang; Duan, Xin-Hua; Luo, Jian-Yi; Wang, Jia; Zhou, Ping-Xin; Liang, Yong-Min; Tetrahedron; vol. 69; 3; (2013); p. 1065 – 1068;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and DMAP (20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanethiol (EtSH, 0.35 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. DIC (0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc/hexanes, to give phosphine 1b as a pale yellow solid (0.43 g, 1.22 mmol, 75percent yield).Data for 1b: 1H NMR (400 MHz, CDCl3) delta=8.02 (m, 1H, Ar.), 7.45-7.24 (m, 12H, Ar.), 6.99 (m, 1H, Ar.), 2.98 (q, 2H, J=7.4 Hz, SCH2CH3), 1.22 (t, 3H, J=7.4 Hz, SCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=192.7, 141.9, 141.7, 138.0, 137.8, 137.7, 134.6, 134.0, 133.8, 131.7, 128.9, 128.6, 128.4, 128.4, 128.3, 24.0, 14.6. 31P NMR (162 MHz, CDCl3) delta=-5.8. HRMS (ESI+) m/z calculated for (C21H20OPS)+ 351.0968, measured 351.0953.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: Cu(I) complexes were synthesized by the following route: [Cu(CH3CN)4](PF6) (0.124g, 0.4mmol) and bis(2-(diphenylphosphanyl)phenyl ether (POP) (0.216g, 0.4mmol) reacted in dichloromethane (15mL) at 25C for 2h. Then, the corresponding ligand (0.4mmol) was dissolved in the degassed dichloromethane solution and injected into the mixed solution for 2h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. Addition of Et2O (10mL) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. And the product was recrystallized with ethanol., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Chai, Chaoyang; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Inorganica Chimica Acta; vol. 488; (2019); p. 34 – 40;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.

Example 4; (g) Preparation of tri(dimethylamino) butylphosphonium butylsulfate; In an eggplant-shaped two-neck flask equipped with a reflux condenser, a dropping funnel and a magnetic stirrer, 37.4 g (178 mmol) of diethylsulfate were added dropwise to 24.2 g (149 mmol) of hexamethylphosphorous triamide at room temperature in a nitrogen gas atmosphere. After 3-day stirring at room temperature, a white solid salt was obtained. The salt was washed sufficiently with ether and vacuum-dried at 50C for 5 hours to obtain tri(dimethylamino) butylphosphonium butylsulfate with 94% yield. The resulting compound was identified with a nuclear magnetic resonance spectrometer (BRUKER Ultra Shield 300 NMR Spectrometer, supplied by BRUKER Corp.). The spectrum data are shown below. 1H-NMR (300 MHz, solvent: acetone-d6, reference material: tetramethylsilane) delta 3.83 (t, 2H) 2.85 (d, 18H) 2.73-2.63 (m, 2H) 1.70-1.33 (m, 8H) 0.97 (t, 3H) 0.90 (t, 3H) The structural formula is shown below (a dashed line in the formula represents a conjugated structure)., 1608-26-0

The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kanto Denka Kogyo CO., LTD.; EP1876181; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-19-8,Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Step 7: 1-(3-Fluoro-4-(1-(4-methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]inden-4-ol A mixture of 4-bromo-1-(3-fluoro-4-(1-(4-methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]indene (3.00 g, 5.47 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine (1.16 g, 2.73 mmol), tris(dibenzylideneacetone)dipalladium(0) (2.50 g, 2.73 mmol) and potassium hydroxide (770 mg, 13.7 mmol) in dioxane (90 mL) and water (18 mL) was stirred at 100 C. for 4 h. The resulting mixture was evaporated in vacuo. The residue was purified via flash chromatography on silica gel (solvent gradient: 0-10% methanol in DCM) to yield 1.20 g (45%) of the title compound as a gray solid. LCMS: [M+H]+=486., 564483-19-8

The synthetic route of 564483-19-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Compounds 1d? was prepared according to the reported procedures.2 The 1d? (320 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed invacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-benztriazole-1-N,N,N?,N?-tetraethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol),followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 18 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried over Na2SO4. The solvent was removed in vacuo to afford the crude product as colourless oil, which was purified by flash chromatography (15percent EtOAc in hexanes) yielding the precat 1d (356 mg, 70percent), 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Zhou, Zhipeng; Zheng, Xiaojun; Liu, Jialin; Li, Jinlei; Wen, Pushan; Wang, Haifei; Synlett; vol. 28; 8; (2017); p. 999 – 1003;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

A hexane solution (30 mL) of 4 (20 mg, 0.23 mmol) and PTh3 (10 mg, 0.035 mmol) was heated to reflux for 1 h during, during which time the color of the solution changed from pale yellow to orange. The solvent was then removed under reduced pressure and the residue was subjected to TLC on silica gel. Elution with hexane/CH2Cl2 (7:3, v/v) developed only one band that corresponded to 5 (16 mg, 61%)., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uddin, Md Miaz; Begum, Noorjahan; Ghosh, Shishir; Sarker, Jagodish C.; Tocher, Derek A.; Hogarth, Graeme; Richmond, Michael G.; Nordlander, Ebbe; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 812; (2016); p. 197 – 206;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13885-09-1,2-(Diphenylphosphino)biphenyl,as a common compound, the synthetic route is as follows.

A solution of CuI (0.019 g, 0.1 mmol) in CH3CN(5 mL) wasadded to a stirred solution of 2,2?-Bipy (0.016 g, 0.1 mmol)and 2-(Dpp)bp (0.034 g, 0.1 mmol) in CH3CN(5 mL). Themixture was stirred for 10 min, with no visible precipitation.After filtration, the clear filtrate was set aside for evaporationin air. Orange block crystals of complex 4 were obtainedafter several hours. Yield: 43.4 mg (63.4percent, based on Cu).Anal. Calc. for 4 C34H27N2P1Cu1I1:C, 59.63; H, 3.94; N,4.09. Found (percent): C, 59.64; H, 3.92; N, 3.98. IR (KBr pellet,cm?1): 3430sh, 3054vw, 1610m, 1431s, 1146w, 1103w,770, 699.

13885-09-1, As the paragraph descriping shows that 13885-09-1 is playing an increasingly important role.

Reference£º
Article; Chen, Di; Chai, Wen-Xiang; Song, Li; Transition Metal Chemistry; vol. 43; 6; (2018); p. 517 – 527;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 1 (0.2 mmol) in 2 mL of CH3CN/H2O(v/v = 100/1) was added Selectfluor (71 mg, 0.2 mmol). The mixture was stirred at room temperature for 5-60minutes. After removal of the solvent, the residue was then purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate to give the desired product 2.

29949-84-6, As the paragraph descriping shows that 29949-84-6 is playing an increasingly important role.

Reference£º
Article; Chen, Qian; Zeng, Jiekun; Yan, Xinxing; Huang, Yulin; Du, Zhiyun; Zhang, Kun; Wen, Chunxiao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3379 – 3381;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate