With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
EXAMPLE 8 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs,1H).
855-38-9 Tris(4-methoxyphenyl)phosphine 70071, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Lonza AG; US5892032; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate