Analyzing the synthesis route of 1070663-78-3

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1070663-78-3,Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

1070663-78-3, [Pd(allyl)(brettphos)]OTf was synthesized according to the literature.[4] A dry Schlenk flask equipped with a Teflon-coated magnetic stirring bar was charged with [(allyl)PdCl]2 (183 mg, 0.5 mmol) followed by AgOTf (257 mg, 1.0 mmol). The flask was fitted with a rubber septum, evacuated, and backfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated two additional times. Solvent (10 mLof THF) was added, and the reaction mixture was stirred at room temperature for 30min while protected from light. A second dry Schlenk flask was equipped with a magnetic stirring bar, fitted with a Schlenk frit, and charged with BrettPhos (537 mg,1.0 mmol). The flask was fitted with a rubber septum, and it was evacuated andbackfilled with nitrogen. This evacuation/nitrogen backfill cycle was repeated twoadditional times. The solution from the first Schlenk flask was transferred through amillipore filter (to remove AgCl) into the second Schlenk flask containing the ligand,rinsing with 5 mL of additional solvent (THF). This mixture was stirred at roomtemperature for 2 h. Hexanes (450 mL) was then added to the mixture to fullyprecipitate the product. The solid materials were then collected by suction filtration,washed with additional hexanes, and dried in vacuo to give 734 mg (86%) of the titlecompound as a yellow solid.

1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Wentong; Kuang, Yi; Wang, Zhifan; Zhu, Jin; Wang, Yuanhua; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 542 – 550;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate