4559-70-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4559-70-0,Diphenylphosphine oxide,as a common compound, the synthetic route is as follows.
General procedure: Under an argon atmosphere, the carbonyl compounds (0.24 mmol, 1.2 eq), TsNHNH2 (0.252 mmol, 1.26 eq) and anhydrous dioxane (2.0 mL) were successively added to a flame-dried Schlenk flask. The reaction was heated at 60 ?C with stirring for 30 minutes. After the solution cooled down to room temperature diphenyl phosphine oxide 1a (0.20 mmol, 1.0 eq), K2CO3 (0.60 mmol, 3.0 eq), and CuI (0.02 mmol, 10 mol %) were sequentially added to the system. The mixture was stirred to reflux. When the reaction was considered complete, as determined by TLC analysis, the reaction mixture was cooled to room temperature. Water was added to the mixture and extracted with ethyl acetate twice. The combined organic phase was washed with brine and dried over Na2SO4. The concentrated residue was purified by column chromatography over silica gel using petroleum ether/ethyl acetate (1:1) as eluent to get the product.
The synthetic route of 4559-70-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chen, Zi-Sheng; Zhou, Zhao-Zhao; Hua, Hui-Liang; Duan, Xin-Hua; Luo, Jian-Yi; Wang, Jia; Zhou, Ping-Xin; Liang, Yong-Min; Tetrahedron; vol. 69; 3; (2013); p. 1065 – 1068;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate