With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1608-26-0,N,N,N’,N’,N”,N”-Hexamethylphosphinetriamine,as a common compound, the synthetic route is as follows.
Example 4; (g) Preparation of tri(dimethylamino) butylphosphonium butylsulfate; In an eggplant-shaped two-neck flask equipped with a reflux condenser, a dropping funnel and a magnetic stirrer, 37.4 g (178 mmol) of diethylsulfate were added dropwise to 24.2 g (149 mmol) of hexamethylphosphorous triamide at room temperature in a nitrogen gas atmosphere. After 3-day stirring at room temperature, a white solid salt was obtained. The salt was washed sufficiently with ether and vacuum-dried at 50C for 5 hours to obtain tri(dimethylamino) butylphosphonium butylsulfate with 94% yield. The resulting compound was identified with a nuclear magnetic resonance spectrometer (BRUKER Ultra Shield 300 NMR Spectrometer, supplied by BRUKER Corp.). The spectrum data are shown below. 1H-NMR (300 MHz, solvent: acetone-d6, reference material: tetramethylsilane) delta 3.83 (t, 2H) 2.85 (d, 18H) 2.73-2.63 (m, 2H) 1.70-1.33 (m, 8H) 0.97 (t, 3H) 0.90 (t, 3H) The structural formula is shown below (a dashed line in the formula represents a conjugated structure)., 1608-26-0
The synthetic route of 1608-26-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kanto Denka Kogyo CO., LTD.; EP1876181; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate