17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and DMAP (20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanethiol (EtSH, 0.35 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. DIC (0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc/hexanes, to give phosphine 1b as a pale yellow solid (0.43 g, 1.22 mmol, 75percent yield).Data for 1b: 1H NMR (400 MHz, CDCl3) delta=8.02 (m, 1H, Ar.), 7.45-7.24 (m, 12H, Ar.), 6.99 (m, 1H, Ar.), 2.98 (q, 2H, J=7.4 Hz, SCH2CH3), 1.22 (t, 3H, J=7.4 Hz, SCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=192.7, 141.9, 141.7, 138.0, 137.8, 137.7, 134.6, 134.0, 133.8, 131.7, 128.9, 128.6, 128.4, 128.4, 128.3, 24.0, 14.6. 31P NMR (162 MHz, CDCl3) delta=-5.8. HRMS (ESI+) m/z calculated for (C21H20OPS)+ 351.0968, measured 351.0953.
The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate