With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6224-63-1,Tri-m-tolylphosphine,as a common compound, the synthetic route is as follows.
TfOCH2CF2H (0.257 g, 1.2 mmol) was reacted with tris (m-tolyl) phosphine (0.365 g, 1.2 mmol) The reaction was stirred at 120 ¡ã C for 6 h, The resulting solid was then treated with ether, Toluene, N-hexane or petroleum ether, filter, And then pump dry, The product (E)-[(3-CH3C6H4)3PCHCHP(3-CH3C6H4)3][OTf]2 (white solid, 0.447g,0.48mmol) Yield: 80percent., 6224-63-1
As the paragraph descriping shows that 6224-63-1 is playing an increasingly important role.
Reference£º
Patent; Wuhan University of Technology; Zhang, Chengpan; Wang, Shimeng; Dongh, Tao; Han, Jiabin; (10 pag.)CN105017320; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate