564483-18-7, 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
564483-18-7, Example 38A (4-Nitrophenyl)-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 300 mg (1.97 mmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine, 326 mg (2.36 mmol) of 4-nitroaniline, 90 mg (0.10 mmol) of tris(dibenzylideneacetone)dipalladium, 51 mg (0.1 mmol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 598 mg (4.33 mmol) of potassium carbonate in 3.00 ml of degassed tert-butanol is stirred in a sealed pressure vessel at 100 C. for 3 h. After cooling to RT, the reaction mixture is filtered through kieselguhr, the kieselguhr is washed with ethyl acetate/methanol 100:5 and the solvent of the filtrate is removed. The residue is taken up in dichloromethane. The crystallized solid is filtered off, washed with dichloromethane and dried. Mother liquor and filtrate are combined and concentrated under reduced pressure. Purification of the residue by preparative HPLC yields the target product. Yield: 340 mg (78% of theory) LC-MS (Method 3): Rt=1.38 min. MS (ESI pos.): m/z=255 (M+H)+. 1H-NMR (DMSO d6, 300 MHz): delta=6.48-6.58 (m, 1H), 6.97 (d, 1H), 7.28-7.42 (m, 3H), 8.08 (d, 1H), 8.19 (d, 2H), 9.55 (s, 1H), 11.62 (s, 1H).
The synthetic route of 564483-18-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate