819867-21-5,819867-21-5, Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-([1,2,4]triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and 3-bromo-[1,2,4]triazolo[4,3-b]pyridine (10.3 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 80 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity, yielding the desired product (10.2 g, 37%).
819867-21-5 Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 67475893, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate