17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
17261-28-8, A mixture of NBD-Cl (400 mg, 2 mmol) and 2-(methylamino) ethan-1-ol (200 mL, 2.5 mmol) was dissolved in20 mL CH2Cl2, and then DIPEA (430 mL, 2.5 mmol) was added. Thereaction mixture and stirred at room temperature for 2 h. Themixture was washed by water (3 25 mL) and brine, and dried byNa2SO4. After removing the solvent under reduced pressure, theresidue was purified by silica gel column chromatography to give ared solid 3a (138 mg, 29%). 1H NMR (400 MHz, MeOD) d 8.54 (d,J 9.1 Hz, 1H), 6.44 (d, J 9.1 Hz, 1H), 4.33 (s, 2H), 3.95 (t, J 5.5 Hz,2H), 3.62 (s, 3H). 2-(Diphenylphosphanyl) benzoic acid (123 mg,0.41 mmol), EDC (84 mg, 0.44 mmol) and DMAP (54 mg,0.44 mmol) were dissolved by CH2Cl2, and then 3a (80 mg,0.34 mmol) was added. The mixture was stirred at room temperatureunder nitrogen protection overnight. After removing thesolvent under reduced pressure, the resulting residue was purifiedby silica gel column chromatography with CH2Cl2 to get an orangefoam 3 (146 mg, 87%). 1H NMR (400 MHz, CDCl3) d 8.36 (d,J 8.9 Hz, 1H), 7.78 (s, 1H), 7.34 (dt, J 10.8, 6.1 Hz, 8H), 7.21 (dd,J 10.4, 4.9 Hz, 4H), 6.91 (s, 1H), 6.04 (d, J 9.0 Hz, 1H), 4.52 (t,J 5.3 Hz, 2H), 4.37 (s, 2H), 3.35 (s, 3H). 13C NMR (101 MHz, CDCl3)d 166.4, 145.42 (s), 144.7, 140.97 (s), 140.7, 137.5, 135.2, 134.6, 134.0,133.8,133.3,133.1,132.6,130.5,128.9,128.6,128.4,123.2,102.0, 62.2,54.2, 41.9. 31P NMR (162 MHz, DMSO-d6) d 4.37. HRMS (ESI): m/z[MH] calcd. for C28H24N4O5P: 527.1479; found: 527.1488.
The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ma, Dejun; Kang, Xueying; Gao, Yasi; Zhu, Jiqin; Yi, Long; Xi, Zhen; Tetrahedron; vol. 75; 7; (2019); p. 888 – 893;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate