1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1070663-78-3, EXAMPLE FORTY-FIVE: Synthesis of BrettPhosPd(3,5-dimethylphenyl)Br (19); In a nitrogen filled glovebox, a solution of BrettPhos (1, 172 mg, 321 mumol), 3,5- dimethylbromobenzene (225 muL) and THF (15 rnL) was added to solid (COD)Pd(CH2SiPhMe2)2 (150 mg, 292 mumol) in an oven-dried 100 mL round bottom flask. The flask was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (60 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 19 (185 mg, 77%) as light-yellow microcrystalline powder as a THF mono-solvate: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.01-7.08 (m, 2H – major, 4H – minor), 6.90 (s, 2H – minor), 6.89 (dd, J= 9.2, 2.8, IH – major), 6.83 (d, J= 8.8 Hz, IH -major), 6.64 (s, 2H – major), 6.41 (s, IH – minor, 2H – major), 4.31 (s, 3H – minor), 3.78 (s, 3H -major), 3.59 (s, 3H – minor), 3.32 (s, 3H – major), 3.03-3.06 (m, IH – major), 2.88-2.92 (m, IH – major), 2.70-2.79 (m, 2H – major), 2.45-2.51 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 2.14 (s, 6H -major), 2.12 (s, 6H – minor), 1.50-1.90 (m, major and minor), 1.05-1.45 (m), 0.75- 0.90 (m, 12H – major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 45.0 (minor), 37.5 (major). Anal CaIc C43H62BrO2PPd: C, 62.36; H, 7.55. Found: C, 62.52; H, 7.68.
The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate