Day: September 27, 2020

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, Under argon a solution of 2-(ethylthio)ethanamine (0.36 g, 3.44 mmol) in THF (3 ml) is added to a solution of 2-(diphenylphosphino)benzaldehyde (1.00 g, 3.44 mmol) in THF (10 ml). After stirring for 12 h at 72 ¡ãC the reaction mixture is cooled to 0 ¡ãC, DCM (3 ml) is added and the solvents are evaporated under vacuo. SNP-ligand N-(2- (diphenylphosphino)benzylidene)-2-(ethylthio)ethan-amine is obtained as an orange solid (1.20 g, 92percent). Analytical data: 1H-NMR (400 MHz, CDCl3): 8.92 (d, 7=4.80, 1H), 8.00 (m, 1H), 7.41 (m, 1H), 7.38-7.28 (m, 11H), 6.91 (m, 1H), 3.70 (dt, 7=1.26, 7.07, 2H), 2.62 (t, 7=7.33, 2H), 2.50 (q, 7=7.33, 2H), 1.23 (t, 7=7.33, 3H). 13C-NMR (400 MHz, CDCl3): 161.12, 139.67, 137.93, 136.96, 136.87, 134.42, 133.77, 130.74, 129.28, 129.01, 128.13, 61.64, 32.56, 26.49, 15.28. 31P-NMR (500 MHz, CDCl3): -13.55 (s, IP). GC/MS: 377 (6percent, M+), 348 (54percent, [M-29]+), 288 (100percent), 226 (20percent), 208 (14percent), 183 (28percent), 165 (14percent), 107 (11percent), 89 (34percent), 61 (14percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GIVAUDAN SA; GEISSER, Roger Wilhelm; OETIKER, Juerg Daniel; SCHROeDER, Fridtjof; WO2015/110515; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Into a 1 L three-neck round-bottom flask equipped with a 250 mL addition funnel, a reflux condenser and a nitrogen inlet, 70 g of recrystallized tri(4-methoxyphenyl)phosphorus and 300 mL of dry THF were added. To the solution, 2.8 g of thin lithium pieces were added at 25 C. under nitrogen with stirring. LiP(4-OMe-Ph)2 was immediately formed in the solution, and the solution turned to a deep reddish yellow color while a large amount of heat was generated. The temperature of the solution was elevated slowly to 55 C. for 1 hour, and the solution was cooled again to 25 C. for 2 hours with stirring. The formed 4-methoxyphenyllithium was decomposed by dropwise adding 18.5 g of distilled and purified t-butylchloride for 45 min. The transparent reddish yellow solution was boiled for 5 min, and then cooled again to -4 C.

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; SK GLOBAL CHEMICAL CO., LTD.; SK INNOVATION CO., LTD.; US2012/130086; (2012); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 (0.0755 g, 0.0882 mmol) and dppf (0.0492 g, 0.0887 mmol) was suspended in acetone (10.0 mL) and refluxed for 3 h. The solution was filtered by gravity, the filtrate reduced and cold hexane added to yield a solid. The solid was collected by suction filtration and dried in vacuo. 5: yield: 0.0972 g (78percent) of orange powder, mp 200.0¡ãC (dec. without melting). 1H NMR (399.95 MHz, DMSO-d6): delta (ppm)=8.19 (d, 4JHP=4.03 Hz, 2H, HC=N); 7.47?7.87 (m, 20H, PPh2); 6.74 (s, 4H, NH2); 5.18 (br s, 4H, 2¡Á C5H4(dppf)); 5.07 (br s, 4H, 2¡Á C5H4); 4.87 (br s, 4H, 2¡Á C5H4(dppf)); 4.51 (br s, 4H, 2¡Á C5H4); 4.14 (s, 10H, 2¡Á C5H5). 13C NMR (100.65 MHz, DMSO-d6): delta (ppm)=171.5; 152.5; 134.4; 132.8; 131.5; 131.2; 131.0; 128.1; 76.2; 75.8; 73.7; 72.8; 71.4; 69.2. 31P NMR (162.00 MHz, DMSO-d6): delta (ppm)=22.2. FT-IR (KBr, cm?1): nu=3467 (m, N?H); 1602 (w, C=N); 1587 (w, C=N). Elemental analysis for C58H52Cl2Fe3N6Pd2P2S2: found C 49.8, H 4.03, N 5.29, S 4.38percent; calculated C 49.4, H 3.72, N 5.96, S 4.55percent. MS-ESI+: m/z 669 ([M?2Cl]2+, 70percent).

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adams, Muneebah; De Kock, Carmen; Smith, Peter J.; Malatji, Peter; Hutton, Alan T.; Chibale, Kelly; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 739; (2013); p. 15 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: [Cu(CH3CN)4]ClO4 (32.6 mg, 0.100 mmol) was added to a DCMsolution (about 12 mL) of dap (10.7 mg, 98percent, 0.0500 mmol) andxantphos (59.0 mg, 98percent, 0.100 mmol) under a stream of dry argonby using Schlenk techniques at room temperature and a vacuumlinesystem, then orange-red solution was obtained quickly andstirred for 1 h at room temperature. The above process can alsobe carried out in air with the existence of oxygen. After filtrationthrough absorbent cotton, layering n-hexane onto the DCM solutionin air produced the product as bluish violet to black-blue blockcrystals in 76percent yield (63.0 mg)., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Article; Yao, Xi-Xi; Guo, Ya-Meng; Liu, Rong; Feng, Xiao-Yan; Li, Hao-Huai; Liu, Nian; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 92; (2015); p. 84 – 92;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, General procedure: General procedures for the synthesis of 2-6: To a solution of 1 (0.2mmol) and monophosphines (0.2mmol) in MeCN, a solution of Me3NO¡¤2H2O (0.2mmol) in MeCN was added. The mixture was stirred at room temperature for 1h (Scheme 3 ). Then the solvent was removed on a rotary evaporator and the residue was subjected to TLC by using CH2Cl2/ petroleum ether as eluent. From the main red band, 2-6 were obtained as red solids with high yields, varying from 67% to 96%. Although complex 2 was reported in the literature [14], we prepared it by a different method and further studied its electrochemical and photochemical properties

As the paragraph descriping shows that 7650-91-1 is playing an increasingly important role.

Reference£º
Article; Li, Rui-Xia; Liu, Xu-Feng; Liu, Ting; Yin, Yi-Bing; Zhou, Ying; Mei, Shun-Kang; Yan, Jing; Electrochimica Acta; vol. 237; (2017); p. 207 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a glovebox, a vial was charged with 1,2-bis(diphenylphosphino)benzene (0.200 g, 0.45 mmol) and 4-trifluoromethylpyrazole (0.061 g, 0.45 mmol). Toluene (5 mL) was added, followed by a mesitylcopper(I) solution (0.068 g, 0.3733 mmol, in 5 mL toluene). The resulting yellow solution was heated at 60C for 15 hours. The mixture was cooled, and concentrated, and washed with hexanes (3×10 mL), to provide a material that was primarily the desired product. The mixture was further washed with toluene (2 x 2 mL), and dried to afford the title complex, as a yellow solid (144 mg). Pale yellow crystals were grown out of a concentrated toluene solution. Single crystal X-Ray diffraction studies supported the ChemDraw structure shown above.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; DOW GLOBAL TECHNOLOGIES LLC; LAITAR, David S.; CLARK, Thomas P.; RACHFORD, Aaron A.; MUKHOPADHYAY, Sukrit; DE VRIES, Timothy S.; DEVORE, David D.; (31 pag.)WO2016/57441; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, A mixture of NBD-Cl (400 mg, 2 mmol) and 2-(methylamino) ethan-1-ol (200 mL, 2.5 mmol) was dissolved in20 mL CH2Cl2, and then DIPEA (430 mL, 2.5 mmol) was added. Thereaction mixture and stirred at room temperature for 2 h. Themixture was washed by water (3 25 mL) and brine, and dried byNa2SO4. After removing the solvent under reduced pressure, theresidue was purified by silica gel column chromatography to give ared solid 3a (138 mg, 29%). 1H NMR (400 MHz, MeOD) d 8.54 (d,J 9.1 Hz, 1H), 6.44 (d, J 9.1 Hz, 1H), 4.33 (s, 2H), 3.95 (t, J 5.5 Hz,2H), 3.62 (s, 3H). 2-(Diphenylphosphanyl) benzoic acid (123 mg,0.41 mmol), EDC (84 mg, 0.44 mmol) and DMAP (54 mg,0.44 mmol) were dissolved by CH2Cl2, and then 3a (80 mg,0.34 mmol) was added. The mixture was stirred at room temperatureunder nitrogen protection overnight. After removing thesolvent under reduced pressure, the resulting residue was purifiedby silica gel column chromatography with CH2Cl2 to get an orangefoam 3 (146 mg, 87%). 1H NMR (400 MHz, CDCl3) d 8.36 (d,J 8.9 Hz, 1H), 7.78 (s, 1H), 7.34 (dt, J 10.8, 6.1 Hz, 8H), 7.21 (dd,J 10.4, 4.9 Hz, 4H), 6.91 (s, 1H), 6.04 (d, J 9.0 Hz, 1H), 4.52 (t,J 5.3 Hz, 2H), 4.37 (s, 2H), 3.35 (s, 3H). 13C NMR (101 MHz, CDCl3)d 166.4, 145.42 (s), 144.7, 140.97 (s), 140.7, 137.5, 135.2, 134.6, 134.0,133.8,133.3,133.1,132.6,130.5,128.9,128.6,128.4,123.2,102.0, 62.2,54.2, 41.9. 31P NMR (162 MHz, DMSO-d6) d 4.37. HRMS (ESI): m/z[MH] calcd. for C28H24N4O5P: 527.1479; found: 527.1488.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Dejun; Kang, Xueying; Gao, Yasi; Zhu, Jiqin; Yi, Long; Xi, Zhen; Tetrahedron; vol. 75; 7; (2019); p. 888 – 893;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.607-01-2,Ethyldiphenylphosphine,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloromethylbenzothiazole (1) (0.183 g, 0.001 mol) andpotassium iodide (KI) (0.166 g, 0.001 mol) were taken intoa round bottomed flask containing 20 mL of THF. Thereaction mixture was stirred for 3 h at 40C. After completionof the reaction as checked by TLC, cooled the reactionmass to RT and then filtered to remove the salt (KCl),resulted in iodo compound, 2-(iodomethyl) benzo[d]thiazole(2). The filtrate was transferred into a flask and sodiumazide (NaN3) (0.065 g, 0.001 mol) was added. The reactionmixture was stirred at 25-30C for 3 h to form an intermediate,2-azidomethylbenzothiazole (3). The reaction mixturewas filtered to remove the salt, NaI, and filtrate was takenfor the next step.Triphenylphosphine (4a) (0.262 g, 0.001mol) was added to 3under N2 atmosphere. The reaction mixture was stirred at 65-70C for 4 h and the progress of the reaction was monitored byTLC using ethylacetate: n-hexane (2:3) as an eluent. After completionof the reaction, the solvent was removed from the reactionmixture in a rotaevaporator to get the crude product and itwas purified by column chromatography using ethylacetate:nhexane(1:4) to obtain pure product, N-(1,3-Benzothiazol-2-ylmethyl)-N-(1,1,1-triphenyl-lambda5-phosphanylidene) amine (5a).The same procedure was adopted for the synthesis of remainingtitle compounds and the physical data of these compounds aresummarized in Table 1., 607-01-2

Big data shows that 607-01-2 is playing an increasingly important role.

Reference£º
Article; Madhava; Subramanyam; Thaslim Basha; Jawahar Babu; Naga Raju; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 16 – 21;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1070663-78-3, EXAMPLE FORTY-FIVE: Synthesis of BrettPhosPd(3,5-dimethylphenyl)Br (19); In a nitrogen filled glovebox, a solution of BrettPhos (1, 172 mg, 321 mumol), 3,5- dimethylbromobenzene (225 muL) and THF (15 rnL) was added to solid (COD)Pd(CH2SiPhMe2)2 (150 mg, 292 mumol) in an oven-dried 100 mL round bottom flask. The flask was capped, and the resulting yellow solution was allowed to stand for 48 h at rt. After this time, pentane (60 mL) was layered on top of the THF solution and the vial was allowed to stand for 24 h resulting in the formation of crystals. After 24 h, the crystals were collected via vacuum filtration in the glovebox, and dried under vacuum to provide 19 (185 mg, 77%) as light-yellow microcrystalline powder as a THF mono-solvate: 1H NMR (400 MHz, CD2Cl2, mixture of rotomers) delta 7.01-7.08 (m, 2H – major, 4H – minor), 6.90 (s, 2H – minor), 6.89 (dd, J= 9.2, 2.8, IH – major), 6.83 (d, J= 8.8 Hz, IH -major), 6.64 (s, 2H – major), 6.41 (s, IH – minor, 2H – major), 4.31 (s, 3H – minor), 3.78 (s, 3H -major), 3.59 (s, 3H – minor), 3.32 (s, 3H – major), 3.03-3.06 (m, IH – major), 2.88-2.92 (m, IH – major), 2.70-2.79 (m, 2H – major), 2.45-2.51 (m, 2H – major), 2.32-2.37 (m, 2H -minor), 2.14 (s, 6H -major), 2.12 (s, 6H – minor), 1.50-1.90 (m, major and minor), 1.05-1.45 (m), 0.75- 0.90 (m, 12H – major and minor), 0.55-0.65 (m, 2H – minor); 31P NMR (162 MHz, CD2Cl2, mixture of rotomers) delta 45.0 (minor), 37.5 (major). Anal CaIc C43H62BrO2PPd: C, 62.36; H, 7.55. Found: C, 62.52; H, 7.68.

The synthetic route of 1070663-78-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2009/76622; (2009); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC-Cu(I) complexes 1-3 were synthesized by the following route:a solution of imidazolium salt (0.4 mmol), copper powder (0.12 g,0.5 mmol) and POP (0.64 g, 1.2 mmol) reacted in CH3CN (5 mL) at 50Cfor 12 h. The resulting mixture was filtered through a plug of Celite andconcentrated to ca. 1 mL. Addition of Et2O (10 ml) to the filtrate affordeda pale yellow precipitate, which was collected and washed withEt2O. And the product was recrystallized with ethanol.2.2.6. [Cu(Ph-BenIm-methPy)](PF6) (1)The product was a white powder. Yield: 0.67 g, 67%. 1H NMR(400 MHz, DMSO-d6): delta 8.25 (d, J =8.3 Hz, 1 H), 8.20 – 8.05 (m, 2 H),7.48 (t, J =7.2 Hz, 1 H), 7.34 (t, J =7.7 Hz, 9 H), 7.22 (dd, J=18.7,7.0 Hz, 9 H), 7.06 (dt, J=26.2, 7.6 Hz, 11 H), 6.92 (s, 4 H), 6.78 (s,2 H), 6.72 (d, J =7.4 Hz, 2 H), 5.36 (s, 2 H), 1.90 (d, J =23.9 Hz, 3 H).13C NMR (101 MHz, DMSO-d6). delta 158.85, 157.42, 157.37, 157.31,149.91, 140.91, 134.83, 134.73, 133.63, 132.93, 132.29, 131.54,131.38, 131.23, 130.14, 128.76, 128.59, 127.55, 125.85, 125.08,124.68, 124.54, 123.73, 123.59, 123.46, 122.98, 119.86, 113.33,112.59, 111.80, 51.57, 24.16. 31P NMR (162 MHz, DMSO) delta -10.31 (s),-143.84 (quint). HRMS (m/z, ESI+): calcd. For C56H45CuN3OP2 ([M]+)900.2334; found 900.2358. Anal. Calcd. For C56H45CuF6N3OP3(1045.4): C 64.28, H 4.33, N 4.02; found: C 64.51, H 4.22, N 4.09., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Jinglan; Chen, Hongyun; Xu, Shengxian; Su, Qingzhi; Zhao, Feng; He, Haifeng; Journal of Photochemistry and Photobiology A: Chemistry; vol. 387; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate