Day: September 25, 2020

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Nitrophenylacetylene (0.077 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuBr2 (0.022 g, 0.1 mmol),Di-tert-butyl peroxide (0.45 g, 3 mmol),Reacts with acetone (2 mL) at 50oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 65%)., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under N2 atmosphere, NaOAc (4.0?equiv), PPh3 1a (0.5?mmol), PdCl2 (10.0?mol?percent), AgOOCCF3 (5.0?equiv), CH3CN (2.0?mL) and methyl acrylate 2a (0.6?mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60?¡ãC for 24?h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

General procedure: Under N2 atmosphere, NaOAc (4.0 equiv), PPh3 1a (0.5 mmol), PdCl2 (10.0 mol %), AgOOCCF3 (5.0 equiv), CH3CN (2.0 mL) and methyl acrylate 2a (0.6 mmol) were successively added into a Schlenk reaction tube. Then the mixture was stirred at 60 C for 24 h. After cooling to room temperature, the solvent was evaporated in vacuo and then purified by flash column chromatography on silica gel to give the pure product 3a.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ma, Ming-Tao; Lu, Jian-Mei; Tetrahedron; vol. 69; 9; (2013); p. 2102 – 2106;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6372-42-5,Cyclohexyldiphenylphosphine,as a common compound, the synthetic route is as follows.,6372-42-5

General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Evren, Enes; Ozdemir, Ismail; Inorganica Chimica Acta; vol. 500; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

224311-51-7, 2-(Di-tert-Butylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 600 mg of tert-butyl 3-bromo-5-cyano-1H-1-indazolecarboxylate produced in Production Example I-14-b in 9 ml tetrahydrofuran were added 21 mg of palladium(II) acetate, 57 mg of 2-(di-tert-butylphosphino)biphenyl, 357 mg of potassium fluoride and 498 mg of 2-benzo[b]thiopheneboronic acid, and the mixture was stirred at 50C for 1 hour. After removing the solvent by distillation, the residue was dissolved in 2 ml of methylene chloride. 4 ml of trifluoroacetic acid was added and the mixture was stirred at room temperature for one day. After removing the solvent by distillation, the residue was diluted with 50 ml of ethyl acetate. The mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The crude product was purified and separated by silica gel column chromatography (ethyl acetate:toluene = 1:19), to give 294 mg of the title compound as bright yellow crystals.1H-NMR (400 MHz, DMSO-D6) d 7.41 (2H, t, J = 7.8 Hz), 7.44 (2H, t, J = 7.8 Hz), 7.80 (2H, s), 7.91 (1H, d, J = 8.0 Hz), 8.01 (1H, d, J = 8.0 Hz), 8.41 (1H, s), 8.99 (1H, s), 13.88 (1H, s)., 224311-51-7

As the paragraph descriping shows that 224311-51-7 is playing an increasingly important role.

Reference£º
Patent; Eisai Co., Ltd.; EP1380576; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

Compound 8 (5.0 g, 9.3 mmol) was melted in 100 mL of CH2C12, and H2O2 (30 percent, 4.0 mL, 186 mmol) was dropped therein while the mixture was being ice bathed. This mixture was stirred for 4 hours. The reactant was quenched with distilled water after stirring, and CH2C12 extraction was performed 3 times. An organic layer was dried with anhydrous magnesium sulfate, and the solvent was distilled off. An obtained solid was purified by a reprecipitation method with use of hexane, which yielded a compound 9 (white powder, 5.0 g, 94 percent). IR (ATR) 1183 (st, P=O), 1070-1226 (st, C-O-C) cm-1 1H NMR (300 MHz, CDCl3, 25 ¡ãC) 87.06-7.71 (m, 26H, Ar), 6.02-6.07 (m, 2H, Ar) ppm 31P NMR (200 MHz, CDCl3, 25 ¡ãC) 826.41 (2P) ppm FAB-Mass(m/z) = 571 [M+H]+., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Patent; National University Corporation Nara Institute of Science and Technology; EP2471799; (2012); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

819867-21-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.819867-21-5,Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Potassium 3-((2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carboxylate Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and ethyl 3-bromo[1,2,4]triazolo[4,3-b]pyridine-7-carboxylate (14.0 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 130 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity. The obtained product is dissolved in dry DMSO (50 ml). Water (1 ml) and potassium tert-butylate (0.6 g) are added and the mixture is stirred for 4 h. The desired product is purified on an ion exchange resin (15.1 g, 47%).

As the paragraph descriping shows that 819867-21-5 is playing an increasingly important role.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

787618-22-8, Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

787618-22-8, (r3-1-tBu-indenyl)2(ji-Cl)2Pd2 (3d) (0.300 g, 0.48 mmol) and RuPhos (0.448 g, 0.98 mmol) were added to a 100 mL Schlenk flask and placed under an atmosphere ofnitrogen. THF (20 mL) was added to the flask via cannula. The resulting solution was stirred for 60 minutes, during which time the reaction mixture became homogeneous. The mixture was opened to air and 90% of the solvent was evaporated under reduced pressure. Pentane was added to precipitate solid from solution. A red-orange solid was collected via vacuum filtration. Yield: 0.694 g, 89%.?H NMR (CDC13, 600 MHz): 7.65-7.61 (m, 1H), 7.43-7.36 (m, 2H), 7.26(obscured by solvent, 1H), 7.01 (t, J = 7.5 Hz, 1H), 6.89 (d, J = 7.4 Hz, 1H), 6.83 (t, J = 7.4Hz, 1H), 6.66-6.58 (m, 4H), 6.40 (s, 1H), 4.66 (d, J = 2.5 Hz, 1H), 4.52-4.44 (sept, J = 6.1Hz, 2H), 2.23 (m, 1H), 2.09 (m, 1H), 2.05-1.99 (m, 2H), 1.69-1.62 (m, 5H), 1.56 (s, 9H),1.49-1.43 (m, 5H), 1.33-1.19 (m, 9H), 1.16-0.92 (m, 11H), 0.54 (d, J= 12.2 Hz, 2H)ppm.?3c{?H} NMR (CDC13, 150 MHz): 157.25, 139.13, 137.57, 137.40, 133.08, 129.40, 128.82,126.03, 125.66, 124.14, 120.81, 118.88, 106.47, 71.42, 71.06, 34.54, 34.51, 30.02, 29.98,27.55, 27.44, 26.31, 22.51, 22.45, 22.42 ppm. 3?P{?H} NMR(CDC13, 121 MHz): 57.13 ppm. Anal. Calcd for C43H58C1PdPO2: C, 66.23; H, 7.50; N, 0.00. Found: C, 66.00; H, 7.48; N,

787618-22-8 Dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphine 121592071, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; YALE UNIVERSITY; HAZARI, Nilay; MELVIN, Patrick; HRUSZKEWYCZ, Damian; (92 pag.)WO2016/57600; (2016); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: A mixture of p-toluenesulfonic acid (10 mg), 2-(diphenylphosphino)benzaldehyde (282 mg, 0,974 mmol) and3-amino-2-(S)-1-hydroxyethyl)-3H-quinazolin-4-one(100 mg, 0,487 mmol) in ethanol (10 mL) and heated at120 ¡ãC for 12 h. The reaction was cooled and analyzed by TLC [ethylacetate:hexane/1:5]. The solvent was evaporatedunder reduced pressure until dryness and the residue wasdissolved in CH2Cl2.The solution was washed with NaHCO3followed by H2Oand the organic phase was dried withNa2SO4.The crude product, obtained by evaporation of thesolvent, was purified by chromatography on silica gel using1:9 ethylacetate:hexane as an eluent. Yield 101 mg (44percent),m.p.: 130?131 ¡ãC (dec.). 1H NMR (400.2 MHz, CDCl3):delta(ppm) 9.88 (d, 1H, JPH = 5.8 Hz, HC = N), 8.12 (m, 2H,ArCH), 7.52 (m, 2H, ArCH), 7.44?7.21 (m, 12H, ArCH),6.84 (m, 2H, ArCH), 4.84 (m, 1H, CH), 4.35 (s, OH), 1.34(d, 3H, J = 6.4 Hz, CH3).13C NMR (100.6 MHz, CDCl3):delta (ppm) 165.5 (d, JPC = 19.2 Hz, N = CH), 158.7?121.6(Ar), 65.4 (CH), 22.1 (CH3). 31P{1H} NMR (162.0 MHz,CDCl3):delta (ppm) ? 15.35 (s). FTIR (KBr, cm?1): 3451 (OH);1687 (C = O); 1607 (C = N); 1435 (P-Ph). Anal. calcd. forC29H24N3O2P:C, 72.95; H, 5.07; N, 8.80percent. Found: C, 73.33;H, 5.29; N, 8.47percent.

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Y?lmaz, Mustafa Kemal; Kele?, Mustafa; Transition Metal Chemistry; vol. 43; 3; (2018); p. 285 – 292;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Cu(I) complexes were synthesized by the following route: [Cu(CH3CN)4](PF6) (0.124g, 0.4mmol) and bis(2-(diphenylphosphanyl)phenyl ether (POP) (0.216g, 0.4mmol) reacted in dichloromethane (15mL) at 25C for 2h. Then, the corresponding ligand (0.4mmol) was dissolved in the degassed dichloromethane solution and injected into the mixed solution for 2h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. Addition of Et2O (10mL) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. And the product was recrystallized with ethanol., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chai, Chaoyang; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Inorganica Chimica Acta; vol. 488; (2019); p. 34 – 40;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate