7650-91-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7650-91-1,Benzyldiphenylphosphine,as a common compound, the synthetic route is as follows.
1. “A”REACTION. BENZYIDIPHENYLPHOSPHINE (APPROXIMATELY 1. 0 G or 3.6 mmol ; Strem CHEMICALS), IrCI3* nH2O (APPROXIMATELY 0.52 g or 1.7 mmol ; available from Johnson Matthey Inc. of West DEPTFORD, NEW Jersey), and ethoxyethanol (approximately 15 ml ; ALDRICH, degassed) can be stirred at approximately 130C for approximately 45 minutes under nitrogen. The yellow precipitate may be isolated by filtration and dried under vacuum to yield approximately 0.78 g of the intermediate product. 31P NMR (202 MHz, CD2CI2, 296 K): -38.83. 2. “B”reaction. The product from the A reaction (approximately 0.30 g) can be combined with the sodium salt of 2,4-pentanedione (approximately 0.59 g or 0.48 mmol ; prepared from the corresponding acid and sodium hydride (both from ALDRICH)) and 2-ethoxyethanol (approximately 15 mL; ALDRICH), and the contents can be stirred under nitrogen at approximately 130C for approximately one hour. The volatile components can then be removed in vacuo, and the product may be purified from the resulting crude off-white solid via silica gel flash chromatography with CH2CI2 as the eluting solvent. The product (approximately 35 mg) may be isolated as a white solid that exhibits blue luminescence under 254 and 365 nm illumination. 31P NMR (202 MHz, CD2CI2, 296 K): -5.28.
The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; E.I. du Pont de Nemours and Company; WO2004/16710; (2004); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate