With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
Using PHEMA-TX-1 as catalyst, the tris(4-methoxyphenyl)phosphane(1a) was transformed into tris(4-methoxyphenyl)phosphineoxide (2a) (Scheme 6). Typically, 1a (352 mg, 1.0 mmol), PHEMA-TX-1(0.52 mg, 0.001 mmol, 19 muL stock solution prepared by dissolving 56 mg PHEMA-TX-1 in 2.0 mL of DMF), CH3OH (30 mL) were addedinto to a 100 mL round bottom flask equipped with a magnetic stirrer.The reaction was triggered by irradiation of a 23W house hold lamp at room temperature under air atmosphere. The photocatalytic reaction was monitored by TLC (eluent: petroleum ether/ethyl acetate=20/1)and finished after 8 h. The solution was concentrated under vacuum and the mixture was again dissolved in 5 mL of ethyl acetate (EA). ThePHEMA-TX-1 was precipitated in EA and recovered for the second cycle of photocatalytic reaction. The NMR yield of 2a in the first cycle was 99% as determined by 1H NMR analysis of the crude reaction mixtureusing dibromomethane as internal standard. Subsequently, using the recovered PHEMA-TX-1 as catalyst, the following cycles of reactionswere performed using the same procedure as above. The result wasshown in Scheme 6. 1H NMR (400 MHz, CDCl3) delta 7.57 (dd, J=9.4,9.4 Hz, 6H), 6.95 (d, J=8.0 Hz, 6H), 3.83 (s, 9H).
The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ding, Aishun; Chen, Yang; Wang, Guowei; Zhang, Yaopeng; Hu, Jianhua; Guo, Hao; Polymer; vol. 174; (2019); p. 101 – 108;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate