With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.
Add 4-methoxycarbonylphenylacetylene to the reaction flask(0.080 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuBr (0.014 g, 0.1 mmol),Di-tert-butyl peroxide (0.30 g, 2 mmol),Reacts with water (2 mL) at 80oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 75%)., 13440-07-8
As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.
Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate