With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid. IR (KBr disk, cm?1): nuC?O 2052 (vs), 1983 (vs), 1976 (vs), 1937 (vs). 1H NMR (500MHz, CDCl3): 7.55?7.50 (m, 6H, PhH), 7.14 (t, J=8Hz, 6H, PhH), 1.93 (d, J=7Hz, 2H, SCH2), 1.19 (d, J=8Hz, 2H, SCH2) ppm. 31P{1H} NMR (200MHz, CDCl3, 85percent H3PO4): 61.45 (s) ppm. 13C{1H} NMR (125MHz, CDCl3): 214.52 (d, JP-C=8.4Hz, PFeCO), 209.66 (FeCO), 164.92, 162.91 (dd, JP-C=1.4Hz, JF-C=251.7Hz, p-PhC), 135.13, 134.03 (dd, JP-C=8.4Hz, JF-C=13.1Hz, o-PhC), 131.67, 131.34 (dd, JP-C=40.7Hz, JF-C=3.4Hz, i-PhC), 116.21, 116.05 (dd, JP-C=10.6Hz, JF-C=21Hz, m-PhC), 34.88 (d, JP-C=2.9Hz, SCH2) ppm. Anal. Calc. for C25H16F3Fe2O5PS2: C, 45.48; H, 2.44. Found: C, 45.54; H, 2.56., 18437-78-0
18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate