Day: September 23, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

Add 4-methoxycarbonylphenylacetylene to the reaction flask(0.080 g, 0.5 mmol), dinaphthylphosphoric acid(0.30 g, 1 mmol), CuBr (0.014 g, 0.1 mmol),Di-tert-butyl peroxide (0.30 g, 2 mmol),Reacts with water (2 mL) at 80oC;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 75%)., 13440-07-8

As the paragraph descriping shows that 13440-07-8 is playing an increasingly important role.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: A dichloromethane solution of [Fe3(mu3-YTe)(CO)9] {Y = S (1), Se(2), Te(3)} (0.1 mmol) was reacted with bis-(diphenylphosphino) ferrocene (55 mg, 0.1 mmol) at room temperature under continuous stirring condition and nitrogen atmosphere for 3 h. The reaction was monitored by TLC. On completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using preparative TLC. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated a red compound, [Fe3YTe(CO)8{eta2-(PPh2)(C5H4)Fe(C5H4)(PPh2)}] {Y = S (8), Se(9), Te(10)} (Yields = 62 mg, 56percent (8), 70 mg, 61percent (9), 86 mg, 72percent (10)) along with unreacted [Fe3YTe(CO)9] and trace amount of a black product and decomposition during the work-up.

12150-46-8, The synthetic route of 12150-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tirkey, Vijaylakshmi; Boddhula, Rajkumar; Mishra, Sasmita; Mobin, Shaikh M.; Chatterjee, Saurav; Journal of Organometallic Chemistry; vol. 794; (2015); p. 88 – 95;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid., 50777-76-9

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

To a solution of (mu-SCH2CH2S-mu)Fe2(CO)6 (0.074g, 0.2mmol) and tris(4-fluorophenyl)phosphine (0.063g, 0.2mmol) in CH2Cl2 (10mL) was added a solution of Me3NO¡¤2H2O (0.026g, 0.23mmol) in MeCN. The mixture was stirred at room temperature for 1h and then the solvent was reduced in vacuo and the residue was subjected to TLC separation using CH2Cl2/ petroleum ether (v/v=1:2) as eluent. From the main red band, 0.111g (84percent) of complex 1 was obtained as a red solid. IR (KBr disk, cm?1): nuC?O 2052 (vs), 1983 (vs), 1976 (vs), 1937 (vs). 1H NMR (500MHz, CDCl3): 7.55?7.50 (m, 6H, PhH), 7.14 (t, J=8Hz, 6H, PhH), 1.93 (d, J=7Hz, 2H, SCH2), 1.19 (d, J=8Hz, 2H, SCH2) ppm. 31P{1H} NMR (200MHz, CDCl3, 85percent H3PO4): 61.45 (s) ppm. 13C{1H} NMR (125MHz, CDCl3): 214.52 (d, JP-C=8.4Hz, PFeCO), 209.66 (FeCO), 164.92, 162.91 (dd, JP-C=1.4Hz, JF-C=251.7Hz, p-PhC), 135.13, 134.03 (dd, JP-C=8.4Hz, JF-C=13.1Hz, o-PhC), 131.67, 131.34 (dd, JP-C=40.7Hz, JF-C=3.4Hz, i-PhC), 116.21, 116.05 (dd, JP-C=10.6Hz, JF-C=21Hz, m-PhC), 34.88 (d, JP-C=2.9Hz, SCH2) ppm. Anal. Calc. for C25H16F3Fe2O5PS2: C, 45.48; H, 2.44. Found: C, 45.54; H, 2.56., 18437-78-0

18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Xu-Feng; Polyhedron; vol. 119; (2016); p. 71 – 76;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29949-84-6,Tris(3-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: A. TfOCH2CF2H(0.514 g, 2.4 mmol) and triphenylphosphine (0.525 g, 2 mmol) were placed in aclosed Schlenk flask under a N2 atmosphere. The mixture was stirredat 120 oC for 24 h and cooled to room temperature. The resultingsolid was washed by diethyl ether, recrystallized from CH2Cl2/hexane,and dried in vacuum to give 0.66 g of (E)-ethene-1,2-diylbis(triphenylphosphonium)ditriflate (3a) as a white solid (0.78 mmol, 78%).2

29949-84-6, The synthetic route of 29949-84-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Shi-Meng; Han, Jia-Bin; Zhang, Cheng-Pan; Qin, Hua-Li; Tetrahedron Letters; vol. 56; 45; (2015); p. 6219 – 6222;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6737-42-4, 1,3-Bis(diphenylphosphino)propane is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6737-42-4, (c) Methyl 3,4-dimethoxy-1-naphthalenecarboxylate A solution of 1-bromo-3,4-dimethoxylnaphthalene (3.72 g, 13.9 mmol), 1,3-bis(diphenylphosphino)propane (0.29 g, 0.7 mmol), palladium acetate (0.16 g, 0.70 mmol), triethylamine (4.85 mL, 34.8 mmol), MeOH (11.5 mL) and DMSO (17 mL) was heated to 75 C. Carbon monoxide was bubbled through the solution for 30 min and the mixture heated under CO (1 atm) for 23 h. The mixture was diluted with brine and extracted with EtOAc (3*70 mL). The organic layers were dried (MgSO4), filtered, and concentrated. Column chromatography gave methyl 3,4-dimethoxy-1-naphthalenecarboxylate as a yellow oil (2.93 g, 85%). 1H NMR (CDCl3) delta 8.89 (m, 1H), 8.21 (m, 1H), 8.06 (s, 1H), 7.52 (m, 2H), 4.06 (s, 3H), 4.02 (s, 3H), 4.00 (s, 3H); MS (APCI) m/z 247 (M+H).

The synthetic route of 6737-42-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astrazeneca AB; US6403601; (2002); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13991-08-7, 1,2-Bis(diphenylphosphino)benzene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,2-Bis(diphenylphosphino)benzene (DPPBz) ligand (0.405g, 0.907mmol) was dissolved in a minimal amount of THF (no more than 7mL) in a glovebox at room temperature with stirring in a 25mL round bottom flask fitted with a rubber septum. Then 0.2mL (0.0907mmol) of Fe(CO)2(NO)2/THF solution (1:1 ratio) was introduced into the flask via syringe. The solution was allowed to stir at room temperature overnight to produce the monosubstituted product, Fe(NO)2(CO)(DPPBz). After stirring, the reaction mixture was taken out of the glovebox and gently heated at 50C for 24h with the reaction progress monitored through FT-IR spectroscopy. The solution was transferred back into the glovebox after completion of the double substitution. Large dark purple crystals of X-ray quality ranging in size from 0.5 to 3mm3were grown by allowing the solvent to slowly evaporate over several days through a vent needle. The crystals and solid powder from the bottom of the flask were filtered and washed with three 0.5mL aliquots of cool toluene.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Holloway, Lauren R.; Clough, Andrew J.; Li, Jessica Y.; Tao, Emily L.; Tao, Fu-Ming; Li, Lijuan; Polyhedron; vol. 70; (2014); p. 29 – 38;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

2-Trifluoromethylphenylacetylene (0.085 g, 0.5 mmol) was added to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuI2 (0.032 g, 0.1 mmol),Tert-butyl alcohol peroxide (0.45 mL, 3 mmol),And ethanol (2 mL),60oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:1) to give the desired product.(Yield 77%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, To a white suspension of P(CH2C6H5)Ph2 (2.08 g, 7.53 mmol) in toluene (20 mL) in a 300 mL Kjeldahl flask, added dropwise a yellow solution of 3c (1.83 g, 7.17 mmol) in toluene (20 mL) at 25 oC. The combined mixture became a clear yellow solution immediately. After stirring for 15 minutes effervescence was observed. The solution was stirred for 4 hours and it remained a clear yellow solution. Removal of the solvent under vacuum afforded a yellow viscous material which was redissolved with CH2Cl2 (20 mL). The resulting clear yellow solution was transferred via cannula over to a suspension of [PyH][BF4] (1.29 g, 7.17 mmol) in CH2Cl2 (20 mL). The Kjeldahl flask was rinsed with CH2Cl2 (2×20 mL) and the rinsing solution was transferred to the reaction flask via cannula. Pyridine (0.9 mL, 10.8 mmol) was added to the white suspension in CH2Cl2 and the reaction mixture was refluxed for 12 hours. After cooling the reaction to 25 oC, a clear yellow solution was observed and the volatiles were removed under vacuum. The resulting viscous residue was washed with diethyl ether (4 x 40 mL) to give a yellow gum. The gum was purified by column chromatography using silica gel (80 g) and CH2Cl2. The column was eluted with CH2Cl2 (200 mL), CH2Cl2-MeOH 98:2 (500 mL), CH2Cl2-MeOH 95:5 (500 mL), CH2Cl2-MeOH 90:10 (500 mL), and CH2Cl2-MeOH 80:20 (500 mL). The fractions (100 mL) were analyzed by UV-Vis, and those that contained the product were combined and dried under vacuum, affording white foam. The foam was treated with CH2Cl2 (100 mL) and diethyl ether (300 mL) to afford a white precipitate. Filtration of the precipitate followed by diethyl ether washes (40 mL) afforded 17 (2.17g, 66%) as a white powder. 1H NMR ((CD3)2SO): delta 9.66 (d, JPH = 10.4, 1H, -P=NH-), 7.97 (m, 4H, 2,6-CH of -(C6H5)2P=NH-), 7.82 (m, 2H, 4-CH of -(C6H5)2P=NH-), 7.70 (m, 4H, 3,5-CH of -(C6H5)2P=NH-), 7.54 (s, 1H, -CH of C6H3SO3), 7.20-7.28 (m, 3H, 2,6- and 4-CH of -C6H5CH2P=NH-), 7.10 (m, 3,5-CH of -C6H5CH2P=NH-), 6.91 (dd, J = 8.0, 1.6, 1H, 4-CH of -C6H3SO3-), 6.64 (d, J = 8.0, 1H, 3-CH of -C6H3SO3-), 5.00 (d, JPH = 14.0, -CH2P=NH-), 2.21 (s, 3H, 5-CH3 of -C6H3SO3-). 1H NMR (CD2Cl2): delta 9.68 (d, JPH = 10.4, 1H, -P=NH-), 7.71-7.85 (m, 7H, 6-CH of -C6H3SO3-, 3,5-CH of -(C6H5)2P=NH-, and 2,6-CH of -C6H5CH2P=NH-), 7.62 (, m, 4H, 2,6-CH of -C6H5CH2P=NH ), 7.28 (m, 1H, 4-CH of -C6H5CH2P=NH), 7.20 (t, J = 7.6, 3,5-CH of -C6H5CH2P=NH-), 6.96 (m, 2H, 4-CH of -(C6H5)2P=NH-), 6.79 (dd, J = 8.4, 2.0, 1H, 4-CH of -C6H3SO3-), 6.34 (d, J = 8.4, 1H, 3-CH of -C6H3SO3-), 4.27 (d, JPH = 14.0, -CH2P=NH-), 2.23 (s, 3H, 5-CH3 of -C6H3SO3-). 31P NMR ((CD3)2SO): delta 35.9. 31P NMR (CD2Cl2): delta 36.1. 13C NMR ((CD3)2SO): delta 137.0 (d, JPC = 7.8), 135.6 (d, JPC = 3.1, para-CH of -(C6H5)2P=NH-), 133.1 (d, JPC = 10.8, ortho-CH of -(C6H5)2P=NH-), 132.7, 132.4, 131.1, 131.0 (d, JPC = 3.1), 130.4 (d, , JPC = 10.8, meta-CH of -(C6H5)2P=NH-), 129.3 (d, JPC = 3.1), 128.5, 128.4, 128.0 (d, JPC = 10.0, ipso C of -C6H5CH2P=NH-), 120.5 (d, JPC = 96.8, ipso C of -(C6H5)2P=NH-), 119.5 (d, JPC = 3.9), 30.9 (d, JPC = 56.5, -CH2P=NH-), 20.5. Anal. Calcd for C26H24NO3PS: C, 67.66; H, 5.24; N, 3.03. Found: C, 67.86; H, 5.33; N, 2.91.

7650-91-1 Benzyldiphenylphosphine 603920, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Burns, Christopher T.; Shang, Suisheng; Thapa, Rajesh; Mashuta, Mark S.; Tetrahedron Letters; vol. 53; 36; (2012); p. 4832 – 4835;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting precursor P – 2 (4.3 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of light yellow all kinds by crystallization, filtration to obtain pure complex [(NHC – 2) Cu (POP)]+PF6-(8.0 G, 7.8 mmol), and the yield is 78percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate