With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.
General procedure: To suspension of sodium dithiocarbamate 2a-f (0.5 mmol) inCH3OH (10 mL) was added a solution of K2PtCl4 (0.210 g,0.50 mmol) in H2O (10 mL). The reaction mixture wasstirred for 30 min. Next, a solution of dppf (0.28 g, 0.50 mmol)in CH2Cl2 (10 mL) was slowly added to the above mixtureand stirred for 24 h. KPF6 (0.46 g, 2.5 mmol) was addedand the mixture was stirred for another 8 h. The solvent wasthen evaporated, and dichloromethane was added to theresidue and the mixture washed with water. The organicphases were dried over anhydrous Na2SO4. The crude productwas purified by chromatography (eluent: CH2Cl2/CH3OH, 50:1, v/v) to give complexes 3a-f.3a: yellow solid, 0.30 g (Yield: 58%). 1H NMR (500MHz, CDCl3): delta 7.64 (m, 7H, -PhH), 7.56 (t, J = 6.8 Hz,5H, -PhH), 7.48 (t, J = 6.9 Hz, 8H, -PhH), 4.57 (s, 4H,-CpH), 4.38 (d, J = 1.7 Hz, 4H, -CpH), 3.54 (t, J = 7.2 Hz,4H, -NCH2-, -NCH2-), 1.20 (t, J = 7.2 Hz, 6H, -CH2CH3,-CH2CH3). 13C NMR (125 MHz, CDCl3): delta 133.94, 133.89,133.85, 132.29, 129.48, 128.99, 128.94, 128.90, 76.18,74.45, 44.67, 12.39. 31P NMR (200 MHz, CDCl3): delta 15.94,-144.30 (m). ESI-MS(+): m/z found 843.1473 [M-Fe-PF6]+,897.0880 [M-PF6]+, calcd for C39H38F6FeNP3PtS21042.0560.
12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.
Reference£º
Article; Xu, Shou De; Wu, Xiang Hua; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 437 – 442;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate