Day: September 22, 2020

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: PR3 and NH4PF6 were added to a solution of fac-[RuCl3(NO)(P?N)] (1) in MeOH (5 mL) and the resulting orange suspensionwas refluxed for 3 h, except for the P(p-Me-C6H4)3 system whenreaction occurred at r.t. After being cooled to room temperature,the resulting yellow suspensions of complexes 3?5 were filteredto give a yellow solid that was washed with H2O (2 5 mL), MeOH(2 5 mL) and Et2O (2 5 mL), and then dried in vacuo. In the caseof complex 2, the reaction generated a clear yellow solution; thesolvent was removed in vacuo to give a yellow residue that wasthen largely dissolved in CH2Cl2 (5 mL), and the mixture wasfiltered through Celite. Addition of n-hexane (15 mL) yielded a yellowsolid that was then treated as described above. The mer, transisomerof 1 [6,7] could also be used as the precursor for synthesesusing the same methodology, which gave similar product yields., 18437-78-0

As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; da Silva, Juliana P.; Fagundes, Francisco D.; Back, Davi F.; Ellena, Javier; James, Brian R.; de Araujo, Marcio P.; Inorganica Chimica Acta; vol. 454; (2017); p. 40 – 45;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: To suspension of sodium dithiocarbamate 2a-f (0.5 mmol) inCH3OH (10 mL) was added a solution of K2PtCl4 (0.210 g,0.50 mmol) in H2O (10 mL). The reaction mixture wasstirred for 30 min. Next, a solution of dppf (0.28 g, 0.50 mmol)in CH2Cl2 (10 mL) was slowly added to the above mixtureand stirred for 24 h. KPF6 (0.46 g, 2.5 mmol) was addedand the mixture was stirred for another 8 h. The solvent wasthen evaporated, and dichloromethane was added to theresidue and the mixture washed with water. The organicphases were dried over anhydrous Na2SO4. The crude productwas purified by chromatography (eluent: CH2Cl2/CH3OH, 50:1, v/v) to give complexes 3a-f.3a: yellow solid, 0.30 g (Yield: 58%). 1H NMR (500MHz, CDCl3): delta 7.64 (m, 7H, -PhH), 7.56 (t, J = 6.8 Hz,5H, -PhH), 7.48 (t, J = 6.9 Hz, 8H, -PhH), 4.57 (s, 4H,-CpH), 4.38 (d, J = 1.7 Hz, 4H, -CpH), 3.54 (t, J = 7.2 Hz,4H, -NCH2-, -NCH2-), 1.20 (t, J = 7.2 Hz, 6H, -CH2CH3,-CH2CH3). 13C NMR (125 MHz, CDCl3): delta 133.94, 133.89,133.85, 132.29, 129.48, 128.99, 128.94, 128.90, 76.18,74.45, 44.67, 12.39. 31P NMR (200 MHz, CDCl3): delta 15.94,-144.30 (m). ESI-MS(+): m/z found 843.1473 [M-Fe-PF6]+,897.0880 [M-PF6]+, calcd for C39H38F6FeNP3PtS21042.0560.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Xu, Shou De; Wu, Xiang Hua; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 437 – 442;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

Into a 100 mL three-necked flask equipped with a magnetic stir bar and nitrogen inlet and outlet were placed commercially available tris(4-methoxyphenyl)phosphine ((12a), 3.0 g, 8.5 mmol) and acetone (30 mL). A mixture of water (2 mL) and H2O2 (35%, 1 mL, 9 mmol) was added slowly. After the mixture was stirred at room temperature for 1 h, acetone was evaporated and methylene chloride (50 mL) was added. The organic phase was washed with a saturated NaCl solution (35 mL) three times. The organic layer was dried over sodium sulfate. The solvent was removed under vacuum to afford 3.0 g (95%) of a white solid, m.p. 144.7-145.4 C. (lit. 143-144 C.). MS (m/e): 368 (M+). Anal. Calcd. for C21H21O4P: C, 68.47%; H, 5.75%; P, 8.41%. Found: C, 68.42%; H, 5.72%; P, 8.11%. FT-IR (KBr, cm-1): 3068, 3026, 2959, 2837, 1597, 1569, 1503, 1468, 1289, 1254, 1179, 1121, 1019, 803, 671, 543. 1H-NMR (CDCl3, 8 in ppm): 3.84 (s, 6H, CH3), 6.94-6.97 (dd, 6H, Ar-H), 7.54-7.60 (dd, 6H, Ar-H). 13C-NMR (DMSO-d6, delta in ppm): 55.29, 114.08, 114.21, 124.19, 125.28, 133.21, 133.32, 161.79, 161.822

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; The United States of America as represented by the Secretary of the Air Force; Tan, Loon-Seng; Wang, David Huabin; (19 pag.)US10294255; (2019); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63995-70-0,Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate,as a common compound, the synthetic route is as follows.,63995-70-0

Add 20mg tricine and 5mg TPPTS to the penicillin vial.Add 0.2 mL of physiological saline to dissolve it. Add 25mug SnCl2¡¤2H2O,Then add 10 muL of DMF solution (1 mg/mL) containing ligand HYNICPBB and 0.5 mL of freshly rinsed 99mTcO4-solution.Reaction at 100 C for 30 min,That is, the 99mTc (HYNICPBB) (tricine/TPPTS) complex of the present invention is obtained.

63995-70-0 Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate 6099338, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Normal University; Zhang Junbo; Song Xiaoqing; Gan Qianqian; Zhang Xuran; Wang Xuebin; Tang Zhigang; Lu Jie; Zhang Zhanbin; (7 pag.)CN110078768; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 5 mmol of tetrakis (acetonitrile) copper (I) [15418-29-8], 5 mmoles of ligand, 5 mmoles of co-ligands and 6 mmol of tris Ethylamine in 50 ml of THF for 20 hours. After the reaction mixture was concentrated to 5 ml and methanol (50 ml) was added dropwise, the fine solids were filtered off by suction and washed twice with 10 ml of methanol and dried in vacuo. The crude product was recrystallized twice from dichloromethane / methanol. The conditioning was carried out in a high vacuum (p approximately 10-6 mbar) at a temperature region of 200 ¡ã C., 166330-10-5

As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENT GMBH; STOESSEL, PHILIPP; HEIL, HOLGER; JOOSTEN, DOMINIK; PFLUMM, CHRISTOF; GERHARD, ANJA; BREUNING, ESTHER; (214 pag.)TWI520958; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

18437-78-0, Tris(4-fluorophenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Complex 1 was synthesized by the simultaneous and dropwise addition of tris-(4-fluorophenyl)phosphine(0.316 g, 1 mmol) in acetone and sodium 4-benzylpiperazine-1-carbodithioate (0.274 g, 1 mmol)in methanol to a methanolic suspension of palladium(II) chloride (0.177 g, 1 mmol). The reaction mixturewas refluxed for 5 h with constant stirring. The resulting orange-colored solution was filtered androtary evaporated to obtained orange solid (scheme 1). It was dried and re-dissolved in chloroform,and on slow evaporation needle-like crystals were obtained. Complexes 2 and 3 were synthesized bythe same method (scheme 1). Complex 1: Yield: 0.50 g (65percent), M.p. 198 ¡ãC. Mol. Wt: 709.47: Anal. Cald (found) for C30H27ClF3N2PPdS2:C, 50.78 (50.71); H, 3.84 (3.83); N, 3.95 (3.92); S, 9.04 (9.00): IR (4000?200 cm?1): 1492 v(C?N); 1010 v(CSSsym);378 v(Pd?S); 303 v(Pd?Cl); 245 v(Pd-P). 1H NMR {CDCl3, 300 MHz, delta (ppm)}: 3.40 (s, 2H, H4), 3.56 (t, 4H,H2, H2?, 3J1H, 1H = 5.1 Hz), 2.27 (t, 4H, H3, H3?, 3J1H, 1H = 5.1 Hz), 7.28?7.40 (m, 17H, H6, H6?, H7, H7?,H8, Hb, Hb?,Hc, Hc?). 13C NMR {CDCl3, 75 MHz, delta (ppm)}: 205.4 (C1); 51.8 (C2, C2?), 46.8 (C3, C3?); 62.5 (C4), 136.8 (C5),129.1 (C6, C6?), 128.2 (C7, C7?), 127.6 (C8), 163.2 (Ca), 115.9 (Cb, Cb?); 124.8 (Cc, Cc?), 165.7 (Cd).

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman; Journal of Coordination Chemistry; vol. 69; 20; (2016); p. 2999 – 3009;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

5518-52-5, Tri(furan-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5518-52-5, (i) Production of 1-(6-Allylnaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol 1-(6-Bromonaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (2.0 g), allyltributyltin (1.26 ml), tris(dibenzylideneacetone)dipalladium (92 mg), tri(2-furyl)phosphine (79 mg) and lithium chloride (432 mg) were dissolved in DMF (20 ml). The solution was stirred at 80 C. for 9 h. The solution was cooled, and diluted with water. The mixture was extracted with ethyl acetate, washed with water and saturated sodium chloride solution, successively, and dried. The solvent was distilled off and the residue was purified by silica gel chromatography (eluent, hexane_THF=6:1) followed by crystallization from isopropyl ether-hexane to give the titled compound (1.57 g) as colorless needles. 1H-NMR (CDCl3) delta: 0.74 (3H, d, J=6.7 Hz), 0.95 (3H, d, J=6.7 Hz), 2.46-2.60 (1H, m), 3.53 (2H, d, J=6.6 Hz), 3.71 (1H, s), 5.07-5.18 (2H, m), 6.04 (1H, ddt, J=3.3, 10.1, 16.9 Hz), 6.80 (1H, d, J=1.4 Hz), 7.10-7.18 (6H, m), 7.27-7.36 (11H, m), 7.54 (1H, dd, J=1.8, 8.6 Hz), 7.57 (1H, s), 7.66-7.78 (2H, m), 7.99 (1H, d, J=1.4 Hz). IR (KBr): 3214, 2969, 1493, 1445, 1015, 907, 816, 748, 700 cm-1.

As the paragraph descriping shows that 5518-52-5 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6573289; (2003); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexyldiphenylphosphine oxide (28.4 mg, 0.1 mmol) to the reaction flask.Copper triflate (3.6 mg, 0.01 mmol), tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), and the mixture was stirred at 80 C;TLC tracks the reaction until it is completely over;The crude product obtained after the completion of the reaction was recrystallized from toluene to give the desired product (yield: 82%)., 13689-20-8

As the paragraph descriping shows that 13689-20-8 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Tao Zekun; (13 pag.)CN110229187; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.12150-46-8,1,1-Bis(diphenylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

General procedure: The reactions were run in a CEM Corp. MARS microwave fitted with a fiber optic temperature probe and a port on top for a reflux condenser.1 mmol of Mo(CO)6 and dppe (0.425 g, 1.1 mmol) were combined with 20 mL of 1-propanol in a two-neck 100 mL RB flask. To this mixture was added NaBH4 (0.128 g, 3.3 mmol). The flaskwas placed in themicrowave and a reflux condenser attached through a hole in the top of the microwave. The mixture was sparged with nitrogen. The mixture was heated under nitrogen at 400 W for 1.5 min to reach reflux temperature. Once the reflux temperature was reached the microwave power was reduced and the temperature maintained for 18 min. The mixture was cooled to room temperature and 2?4 mL of water was added to the reaction to dissolve excess NaBH4 and promote product precipitation. The reaction was cooled ?10 ¡ãC for several hours. The light yellow complex was filtered in air and washed with 2¡Á5 mL of petroleum ether/diethyl ether(1:1) mixture resulting in 580 mg of Mo(CO)4dppe after drying, a 95percent yield.

12150-46-8, 12150-46-8 1,1-Bis(diphenylphosphino)ferrocene 51341936, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Birdwhistell, Kurt R.; Schulz, Brian E.; Dizon, Paula M.; Inorganic Chemistry Communications; vol. 26; (2012); p. 69 – 71;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate