With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9
Compound 1 (90mg, 0.25mmol) and tris(4-methoxyphenyl)phosphine (2, 113mg, 0.32mmol) in acetonitrile (anhydrous, 15mL) were added into a three-necked flask under a stream of nitrogen. After reflux at 100C for 20h and concentrated, the compound Fe-4 (brownish red solid, 65mg, 41%) was obtained via a silica gel chromatography (dichloromethane/methane=20/1, v/v). The chemical purity of compound Fe-4 was >95% by HPLC analysis. 1H NMR (400MHz, CDCl3) delta 7.66-7.61 (m, 6H, CH-Ph), 7.13-7.11 (m, 6H, CH-Ph), 4.72 (s, 2H, CH-Cp), 4.44 (s, 2H, CH-Cp), 4.12 (s, 5H, Cp-Fe), 3.86 (s, 9H, PhOCH3), 3.43 (s, 2H, O=C-CH2), 2.68 (s, 2H, CH2-P), 1.70-1.50 (m, 6H, CH2-CH2-CH2). 13C NMR (100MHz, CDCl3) delta 204.70, 164.61, 135.54, 116.27, 109.09, 78.93, 72.36, 69.89, 69.42, 55.74, 39.28, 30.20, 23.97, 23.52, 22.74.31P NMR (400MHz, CDCl3) delta 22.15. HRMS (+TOF MS): m/z calculated for C37H40FeO4P+ [M]+ 635.2008, found 635.2008.
The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Xiaoyan; Chen, Shuting; Liu, Zelan; Zhao, Zuoquan; Lu, Jie; Journal of Organometallic Chemistry; vol. 871; (2018); p. 28 – 35;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate