Day: September 21, 2020

15929-43-8, Bis(4-(trifluoromethyl)phenyl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a Schlenk flask wereplaced diphenylphosphine oxide (0.2 mmol), and tBuOLi of THF solution (5 mol%, 0.01 mmol) in THF (0.15mL) under nitrogen. The mixture was stirred at ambient temperature for 1 h. Etynylbenzene(0.1 mmol) was added to the solution under nitrogen and the mixture was heatedat 70 C for 4 h., 15929-43-8

As the paragraph descriping shows that 15929-43-8 is playing an increasingly important role.

Reference£º
Article; Yoshimura, Aya; Saga, Yuta; Sato, Yuki; Ogawa, Akiya; Chen, Tieqiao; Han, Li-Biao; Tetrahedron Letters; vol. 57; 30; (2016); p. 3382 – 3384;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.8 (1R,2S)-1-Phenyl-2-(pivalamido)propyl 2-(diphenylphosphinyl)benzoate 9d fx17 Purified by flash column chromatography (80/20, hexanes/EtOAc) to yield 0.256 g (20percent) of product as a yellow oil. [alpha]D23 = -12.7 (c 0.694, CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.86 (d, J = 6.9 Hz, 3H), 1.04 (s, 9H), 4.35-4.41 (m, 1H), 6.00 (s, 1H), 6.02 (d, J = 3.7 Hz, 1H), 6.90-6.93 (m,1H), 7.14-7.26 (m, 16H), 7.31-7.39 (m, 3H), 8.04-8.07 (m, 1H). 13C NMR (100 MHz, CDCl3): delta 14.75, 27.58, 38.67, 49.00, 79.18, 126.62, 127.92, 128.38, 128.57, 128.63, 128.68, 128.73, 128.87, 130.90, 130.94, 132.31, 133.47, 133.66, 133.81, 133.96, 134.17, 134.79, 134.89, 135.00, 137.48, 137.58, 137.69, 139.58, 139.84, 166.33, 177.80. 31P NMR (162 MHz, CDCl3): delta -5.24. IR v (Nujol): 1717, 1652, 1398, 1378, 1251, 746, 697 cm-1. ESI HRMS for C33H34NO3P: calcd (M+H+) 524.2355; found 524.2353.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13689-19-5, Tricyclohexylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, 13689-19-5 Tricyclohexylphosphine oxide 26187, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5518-52-5,Tri(furan-2-yl)phosphine,as a common compound, the synthetic route is as follows.

5518-52-5, EXAMPLE 26B 4-((cyclohexylmethyl)amino)-3-nitro-5-(2-pyrimidinyl)benzenesulfonamide A solution of Example 26A (270 mg, 0.69 mmol), 2-(tributylstannyl)pyrimidine (305 uL, 0.83 mmol), Pd2(dba)3 (32 mg, 0.034 mmol), and tris-(2-furyl)phosphine (32 mg, 0.10 mmol) in acetonitrile (2 mL) was heated to reflux for 48 hours and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product. MS (ESI(+)) m/e 392 (M+H)+.

As the paragraph descriping shows that 5518-52-5 is playing an increasingly important role.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, 2-(Diphenylphosphanyl)benzoic acid (0.50 g, 1.63 mmol) and 4-dimethylaminopyridine (DMAP, 20 mg, 0.163 mmol) were dissolved in CH2Cl2 (10 mL). Ethanol (0.29 mL, 4.89 mmol) was added, and the solution was placed under Ar(g) and cooled to 0¡ã C. N,N’-Diisopropylcarbodiimide (DIC, 0.25 mL, 1.63 mmol) was added dropwise, and the resulting solution was allowed to warm to room temperature and stirred overnight. The solution was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography, eluting with 10percent EtOAc(ethylacetate)/hexanes, to give phosphine 1a as a pale yellow solid (0.44 g, 1.32 mmol, 81percent yield). 2-(Diphenylphosphanyl)benzoic acid was purchased from Sigma-Aldrich (St. Louis, Mo.).Data for 1a: 1H NMR (400 MHz, CDCl3) delta=8.07 (m, 1H, Ar.), 7.44-7.25 (m, 12H, Ar.), 6.93 (m, 1H, Ar.), 4.22 (q, 2H, J=7.1 Hz, OCH2CH3), 1.21 (t, 3H, J=7.1 Hz, OCH2CH3). 13C NMR (100 MHz, CDCl3, 31P-coupled; 1H-decoupled, observed signals) delta=166.9, 140.8, 140.0, 138.1, 137.9, 134.8, 134.6, 134.3, 134.0, 133.8, 131.8, 130.6, 128.6, 128.5, 128.4, 128.2, 61.2, 14.0. 31P NMR (162 MHz, CDCl3) delta=-4.0. HRMS (ESI+) m/z calculated for (C21H20O2P)+ 335.1196, measured 335.1208.

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Patent; Raines, Ronald Thaddeus; Myers, Eddie Leonard; US2010/125132; (2010); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred and degassed solution of [Fe(h5-Cp)(CO)2I] (1 mmol)in dry acetone (30 mL) PR3 (1 mmol) was added. The reactionmixture was then irradiated under UV light (125 W) for 3e7 h (seebelow). The precipitate was separated by cannula-filtration and thesolvent was evaporated under vacuum. The residue was twicerecrystallized from dry dichloromethane/n-hexane and dark greenproducts are obtained.[Fe(h5-Cp)(CO)(PPh3)

18437-78-0, As the paragraph descriping shows that 18437-78-0 is playing an increasingly important role.

Reference£º
Article; Pilon, Adhan; Girio, Patricia; Nogueira, Guilherme; Avecilla, Fernando; Adams, Harry; Lorenzo, Julia; Garcia, M. Helena; Valente, Andreia; Journal of Organometallic Chemistry; vol. 852; (2017); p. 34 – 42;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

63995-70-0, Sodium 3,3′,3”-phosphinetriyltribenzenesulfonate is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63995-70-0

Under argon protection,Add to 50mLSchlenk bottle1 ¡¤ 56 mmol of (SO3Na) 3-R6,4.73 mmol of [CH3 (EO)4N+H=C(N (CH3) 2)2] [CH3SO3-] and 1 mL of acetonitrile,The reaction mixture was stirred at room temperature for 72 hours,Filtration and removal of the filtrate under reduced pressure gave an orange-yellow viscous liquid in 91% yield.

As the paragraph descriping shows that 63995-70-0 is playing an increasingly important role.

Reference£º
Patent; Qingdao University of Science and Technology; JIN, XIN; LI, SHU MEI; ZHAO, KUN; (11 pag.)CN103483381; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

7650-91-1, Benzyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7650-91-1, A 25 mL flask was charged with IrCl3.3H2O (210 mg, 0.6 mmol) and benzyldiphenyl phosphine (331 mg, 1.2 mmol) then dry and degassed 2-methoxyethanol (10 mL) was added as solvent. The reaction mixture was heated at 120 C. for 12 hour. After cooling to room temperature, fppzH (86 mg, 0.4 mmol) and Na2CO3 (636 mg, 6.0 mmol) were added into the flask, followed by stirring at RT for another 3 hour. The reaction was quenched by addition of excess water which resulted in the pale yellow precipitate. The precipitate was collected by the filtration and then washed with ice MeOH and diethyl ether. Purification by flash column using CH2Cl2 as eluent gave a chloride intermediate which could be further purified by recrystallization in mixed CH2Cl2 and hexane solution with 40% yield (240 mg, 0.24 mmol). After then, a mixture of chloride intermediate (99 mg, 0.1 mmol), AgOTf (28 mg, 0.12 mmol) and dry 2-methoxyethanol (5 mL) was refluxed in the dark for 2 hour and then cooled to room temperature. After removal of the white precipitate by filtration, the collected filtrate was added excess water. The resulting white precipitate could be collected by filtration, followed by washing with ice methanol and diethyl ether. Purification was conducted by flash column using CH2Cl2 as eluent and then recrystallization in mixed solution of CH2Cl2 and hexane gave 5a as white powder with 37% yield (70 mg, 0.037 mmol).Spectral data of 5a: MS (FAB, 192Ir), 955 [M+]. 1H NMR (500 MHz, CDCl3, 294K): delta 7.89 (d, J=8.0 Hz, 1H), 7.87 (d, J=8.0 Hz, 1H), 7.50 (d, J=6.5 Hz, 1H), 7.43 (t, J=9.0 Hz, 2H), 7.33-7.25 (m, 3H), 7.21 (d, J=7.5 Hz, 1H), 7.16-7.13 (m, 3H), 7.11-7.08 (m, 5H), 6.96 (t, J=7.5 Hz, 1H), 6.85 (t, J=7.5 Hz, 1H), 6.82-6.79 (m, 3H), 6.77 (s, 1H), 6.72 (t, J=7.3 Hz, 1H), 6.69-6.66 (m, 3H), 6.61 (t, J=8.8 Hz, 2H), 6.43 (t, J=6.8 Hz, 1H), 6.32 (t, J=8.5 Hz, 2H), 6.18 (t, J=5.8 Hz, 1H), 4.05 (dd, J=15.0, 8.8 Hz, 1H), 3.77 (dd, J=15.0, 8.8 Hz, 1H), 3.46 (dd, J=16.5, 9.7 Hz, 1H), 2.17 (dd, J=16.5, 9.7 Hz, 1H). 19F {1H} NMR (470 MHz, CDCl3, 294K): delta -60.27 (s, 3F).31P {1H} NMR (202 MHz, CDCl3, 294K): delta 6.29 (d, J=11.1 Hz, 1P), 6.18 (d, J=11.1 Hz, 1P).

The synthetic route of 7650-91-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YUN CHI; US2008/161568; (2008); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.855-38-9,Tris(4-methoxyphenyl)phosphine,as a common compound, the synthetic route is as follows.,855-38-9

Compound 1 (90mg, 0.25mmol) and tris(4-methoxyphenyl)phosphine (2, 113mg, 0.32mmol) in acetonitrile (anhydrous, 15mL) were added into a three-necked flask under a stream of nitrogen. After reflux at 100C for 20h and concentrated, the compound Fe-4 (brownish red solid, 65mg, 41%) was obtained via a silica gel chromatography (dichloromethane/methane=20/1, v/v). The chemical purity of compound Fe-4 was >95% by HPLC analysis. 1H NMR (400MHz, CDCl3) delta 7.66-7.61 (m, 6H, CH-Ph), 7.13-7.11 (m, 6H, CH-Ph), 4.72 (s, 2H, CH-Cp), 4.44 (s, 2H, CH-Cp), 4.12 (s, 5H, Cp-Fe), 3.86 (s, 9H, PhOCH3), 3.43 (s, 2H, O=C-CH2), 2.68 (s, 2H, CH2-P), 1.70-1.50 (m, 6H, CH2-CH2-CH2). 13C NMR (100MHz, CDCl3) delta 204.70, 164.61, 135.54, 116.27, 109.09, 78.93, 72.36, 69.89, 69.42, 55.74, 39.28, 30.20, 23.97, 23.52, 22.74.31P NMR (400MHz, CDCl3) delta 22.15. HRMS (+TOF MS): m/z calculated for C37H40FeO4P+ [M]+ 635.2008, found 635.2008.

The synthetic route of 855-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Xiaoyan; Chen, Shuting; Liu, Zelan; Zhao, Zuoquan; Lu, Jie; Journal of Organometallic Chemistry; vol. 871; (2018); p. 28 – 35;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate