With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
To the reactor was added 2-diphenylphosphine benzoic acid (5.00 g 16.26 mmol) N-hydroxysuccinimide (3.74 g, 32.52 mmol) and DCC (6.71 g, 32.52 mmol) followed by dichloromethane (80.0 mL), stirred at room temperature for 12 hours, filtered through celite and rinsed with dichloromethane to give the filtrate. Steamed and purified by silica gel column chromatography to give the indicated product The product was pale yellow solid 2 (5.03 g, yield 77percent)., 17261-28-8
17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Chinese Academy Of Sciences Chemical Institute; Shi Yian; Liu Weigang; Pan Hongjie; Tian Hua; (25 pag.)CN105017172; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate