With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.
General procedure: NHC?Cu(I) complexes 1?3 were synthesized by the following route: a solution of imidazolium salt (0.4mmol), copper powder (0.032g, 0.5mmol) and POP (0.22g, 0.4mmol) was reacted in CH3CN (5mL) at 60¡ãC for 24h. The resulting mixture was filtered through a plug of Celite and concentrated to ca. 1mL. The addition of Et2O (10ml) to the filtrate afforded a pale yellow precipitate, which was collected and washed with Et2O. The product was recrystallized with ethanol. [Cu(Ph-BenIm-Py)](PF6), 1. The product was a white powder. Yield: 0.30g, 72percent. 1H NMR (400MHz, DMSO-d6): delta 8.41 (dd, J=20.0, 8.3Hz, 2H), 8.14 (dd, J=15.2, 6.0Hz, 2H), 7.55?7.46 (m, 2H), 7.44?7.31 (m, 8H), 7.27?7.19 (m, 10H), 7.14?6.99 (m, 8H), 6.94 (d, J=7.7Hz, 5H), 6.84 (d, J=7.4Hz, 2H), 6.62 (d, J=3.3Hz, 2H), 5.31 (s, 2H). 13C NMR (101MHz, DMSO-d6). delta 157.54, 150.39, 149.33, 147.58, 141.75, 140.09, 135.23, 134.89, 134.51, 133.67, 132.96, 132.17, 131.58, 131.03, 129.55, 129.15, 128.37, 127.92, 127.57, 126.99, 125.87, 125.23, 124.19, 123.72, 122.98, 121.72, 121.16, 119.69, 114.23, 113.30, 112.59, 111.41, 51.87.31P NMR (162MHz, DMSO-d6): delta?8.95 (s),?143.45 (quint). HRMS (m/z, ESI+): calcd. For C55H43CuN3OP2 ([M]+) 886.2177; found 886.2169. Anal. Calcd. For C55H43CuF6N3OP3 (1032.41): C 63.99, H 4.20, N 4.07; found: C 63.77, H 4.11, N 3.98., 166330-10-5
As the paragraph descriping shows that 166330-10-5 is playing an increasingly important role.
Reference£º
Article; Xu, Shengxian; Wang, Jinglan; Liu, Shaobo; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Molecular Structure; vol. 1153; (2018); p. 12 – 19;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate