1070663-78-3, Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1070663-78-3, General Procedure 1. A solution of BrettPhos (1.5 eq) and aryl bromide (6.0 eq) in THF (15 mL mmol-1) was added to a vial containing (COD)Pd(CH2TMS)2 (1.0 eq). The resulting yellow solution was stirred for 48 h and then layered with twice the volume of pentane and left standing. After 24 h, the resulting solid was filtered off, washed with pentane and dried under vacuum. Preparation of (BrettPhos)Pd(2-Me,4-CF3C6H3)(Br). According to general procedure 1, (COD)Pd(CH2TMS)2 (144 mg, 0.37 mmol) was reacted with BrettPhos (300 mg, 0.56 mmol) and 2-methyl-4-trifluoromethylbromobenzene (531 mg, 2.22 mmol) in 6 mL THF to afford 218 mg (247 mummol, 67%) of the desired complex as a white powder. 31P-NMR (162 MHz, CDCl3): delta=43.9 ppm. 19F-NMR (376 MHz): delta=-62.1 ppm. 1H (500 MHz, CDCl3): complex spectrum, shown in FIG. 9.
1070663-78-3 Dicyclohexyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine 25112535, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; Massachusetts Institute of Technology; US2011/15401; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate