With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1160861-53-9,Di-tert-butyl(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.
A 250-mL round-bottomed flask equipped with a stirbar was charged with 2-aminobiphenylpalladium chloride dimer (3.41 g, 5.5 mmol, 0.50 eq) and silver triflate (2.82 g, 11 mmol, 1.00 eq.) and shielded from light. Then dichloromethane (100 mL) was added and the mixture was stirred at room temperature for 30 min. The suspension was then filtered through a wet pad of Celite into a 500-mL round-bottomed flask equipped with a stir bar containing tBuBrettPhos (5.33 g, 11 mmol, 1.00 eq). An additional portion of dichloromethane (50 mL) was used to rinse the first flask and elute the mixture through the Celite plug. The resulting mixture was stirred at room temperature for 2 h, until becoming deep red in color. After removing 90% of the solvent via rotary evaporation, pentane (200 mL) was added to precipitate the precatalyst. The suspension was sonicated for 30 minutes, crushed with a spatula and filtered. The resulting solid was dried under vacuum overnight to give the title compound as a dark orange solid. Yield: 9.59 g, 96%. FIG. 9.
1160861-53-9, The synthetic route of 1160861-53-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Massachusetts Institute of Technology; Bruno, Nicholas C.; Buchwald, Stephen L.; US2013/331566; (2013); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate