564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
564483-19-8, (2) A suspension of the compound obtained in (1) (107 g), ethyl 1H-pyrazole-4-carboxylic acid (59.22 g), tripotassium phosphate (112.14 g), 2-di-t-butylphosphino-2′,4′,6′-triisopropyl biphenyl (11.22 g) and tris(dibenzylideneacetone)dipalladium(0) (8.06 g) in t-butyl alcohol (1173 mL) was stirred under nitrogen atmosphere for 4 hours at 90 C. The reaction mixture was added with water and filtered, and the resulting crystals were washed with methanol. The crystals were then dissolved in chloroform, and NH-silica gel (300 mL), silica gel (300 mL) and sodium sulfate (200 g) were added, followed by filtration to remove the insoluble material. The filtrate was concentrated under reduced pressure, the residue was added with methanol. The resulting crystals were corrected by filtration to yield ethyl 1-[7-methoxy-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-1H-pyrazole-4-carboxylate (99.62 g, 69% yield) as colorless crystals. MS (ESI) m/z: 409 [M+H]+.
564483-19-8 Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine 11618717, achiral-phosphine-ligands compound, is more and more widely used in various fields.
Reference£º
Patent; MITSUBISHI TANABE PHARMA CORPORATION; Nakajima, Tatsuo; Goi, Takashi; Kawata, Atsushi; Sugahara, Masakatsu; Yamakoshi, Shuhei; US2015/239889; (2015); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate