With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.
General procedure: 4.3.25 methyl 2-phenyl-5-(4-fluorophenyl)thiazole-4-carboxylate (4e) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 118 mg (76percent). White solid, mp 126-128 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.86 (s, 3H), 7.13 (t, J=8.6 Hz, 2H), 7.44-7.47 (m, 3H), 7.50-7.56 (m, 2H), 7.94-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 166.1, 165.0, 162.5, 161.7, 145.3, 140.9, 132.6, 131.9, 131.8, 130.7, 129.0, 126.8, 126.3, 126.2, 115.5, 115.3, 52.3 ppm; IR (KBr) 2944, 1721, 1528, 1468, 1343, 1224, 1200, 1007, 843, 762, 689 cm-1; HRMS (ESI) calcd for [C17H12FNO2S+H]+ 314.0646, found 314.0649.
18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate