Day: September 10, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.240417-00-9,2-Diphenylphosphino-2′-(N,N-dimethylamino)biphenyl,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 2-dimethylamino-2′-(diphenylphosphino)biphenyl (34.3 mg, 0.0899 mmol) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (17.5 mg, 0.0899 mmol) in dry dichloromethane, and the mixture was heated to reflux with stirring for one hour. Then, 2,9-di-n-butyl-1,10-phenanthroline (26.3 mg, 0.0899 mmol) was added to the obtained solution, which was heated to reflux for additional one and half hours. The reaction solution was filtrated, and the filtrate was concentrated and then the residue was dissolved in chloroform followed by slow diffusion of diethylether. The pale yellow precipitate was filtrated, and the filtrated matter was subjected to vacuum drying, thereby providing 45.0 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-1, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (1).

240417-00-9, The synthetic route of 240417-00-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

32.6mg mesityl -Cu and 3ml of toluene were added to 34.6mg (0.18mmol) of 8-PyQ and 79.5mg (0.18 mmol) of dppb in a glove box. It forms a dark Redsolution. This was filtered and coated with n-hexane layer. it forms redcrystals. under UV (356nm), they emit a strong red. the solution in the sameway emits a strong red. Yield: 70%.

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENTGMBH; WESEMANN, LARS; KLEIH, MATTHIAS; MAYER, HERMANN, AUGUST; (72 pag.)JP2016/501830; (2016); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-19-5,Tricyclohexylphosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: The same general procedure was adopted for the synthesis of all the complexes. The lanthanide bromide and tricyclohexylphosphineoxide were dissolved in hot ethanol. Heating was continued for 1 h during which time, in some cases, small quantities of crystalline material formed. Either cooling to room temperature followed by standing for 16 h or on prolonged standing and slow evaporation of the solution afforded crystalline materials. The crystals were filtered, washed with ethanol and dried at the pump. Representative syntheses and characterisations are described below.

13689-19-5, The synthetic route of 13689-19-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bowden, Allen; Lees, Anthony M.J.; Platt, Andrew W.G.; Polyhedron; vol. 91; (2015); p. 110 – 119;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 330 g (7.17 mol) of absolute ethanol are cooled to -15 C. under a nitrogen atmosphere. 26.5 g (1.56 mol) of ammonia gas are introduced thereto at this temperature with constant stirring. 200 g (0.907 mol) of chloro(diphenyl)-phosphine are then added dropwise at this temperature. The mixture is then allowed to come to room temperature with stirring and is then kept under reflux for 11 hours until virtually no more ammonia gas escapes. The mixture is then cooled, filtered by suction, washed with ethanol and dried. 48 g of crude ammonium chloride are obtained. The filtrate is freed from ethanol and any ammonia present in vacuo. The remaining residue is freed from a slight salt precipitate by filtration through a glass frit. 170 g of ethyl diphenylphosphinite are then obtained by thin film distillation at a bath temperature of 160 to 175 C. and a pressure of 0.5 mbar. This corresponds to a yield of 82% of theory., 1079-66-9

As the paragraph descriping shows that 1079-66-9 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US5705669; (1998); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.564483-18-7,2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl,as a common compound, the synthetic route is as follows.

564483-18-7, Example 430 Production of N-{3-[(2-anilinoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide A mixture of N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (100 mg, 0.242 mmol), iodobenzene (32 mul, 0.290 mmol), tris(dibenzylideneacetone)dipalladium (0) (11 mg, 24.2 mumol), dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (23 mg, 48.4 mumol), sodium tert-butoxide (34 mg, 0.362 mmol) and toluene (2 mL) was stirred under an argon atmosphere with heating at 80 C. for 5 hr. After the reaction mixture was allowed to cool to room temperature, saturated aqueous sodium hydrogencarbonate solution was added to the mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=0/100?50/50) to give the title compound (19 mg, 16%) as a pale-green powder. 1H-NMR (DMSO-d6, 300 MHz) delta 6.78 (1H, t, J=7.3 Hz), 6.96-7.07 (2H, m), 7.18-7.25 (2H, m), 7.36-7.50 (3H, m), 7.65-7.72 (3H, m), 7.79 (1H, t, J=7.6 Hz), 7.98 (2H, d, J=9.2 Hz), 8.18-8.32 (2H, m), 8.91 (1H, s), 10.58 (1H, s).

564483-18-7 2-(Dicyclohexylphosphino)-2′,4′,6′-tri-i-propyl-1,1′-biphenyl 11155794, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/137595; (2009); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: To a flame dried, 100 mL round bottom flask under nitrogenwere added (1R,2S)-norephedrine (0.750 g, 4.96 mmol) and 4-(dimethylamino)pyridine (0.120 g, 0.990 mmol). The mixture was dissolved in methylene chloride (15 mL). To this solution,N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (1.07 g, 5.20 mmol) and 2-(diphenylphosphino)benzoic acid (1.59 g, 5.20 mmol) were added and the solution was allowed to stir at room temperature overnight. Methylene chloride (50 mL) was added and the solution was transferred to a separatory funnel and washed with 1 M HCl (50 mL), NH4Cl (50 mL) and with brine(50 mL). The organic extract was dried over anhydrous MgSO4 and the solvent was removed via rotary evaporation. 4.3.6 (1R,2S)-2-(4-Nitrobenzamido)-1-phenylpropyl 2-(diphenylphosphinyl)benzoate 9b fx15 Purified by flash column chromatography (50/50, hexanes/ EtOAc) to yield 0.300 g (43percent) of product as a yellow oil. [alpha]D23 = -18.9 (c, 1.04 CHCl3). 1H NMR (500 MHz, CDCl3): delta 0.94 (d, J = 7.0 Hz, 3H), 4.61-4.68 (m, 1H), 6.29 (d, J = 2.8 Hz, 1H), 7.06-7.09 (m, 1H), 7.19-7.23 (m, 4H), 7.30-7.38 (m, 11H), 7.43-7.50 (m, 3 H), 7.99 (d, J = 8.8 Hz, 2 H), 8.05-8.08 (m, 1H), 8.18 (d, J = 8.8 Hz, 2H). 13C NMR (100 MHz, CDCl3): delta 13.95, 50.41, 79.33, 123.66, 126.10, 128.13, 128.49, 128.52, 128.59, 128.68, 128.75, 128.89, 129.08, 129.17, 130.78, 130.82, 132.42, 133.28, 133.46, 133.76, 133.96, 134.10, 135.11, 135.43, 135.66, 136.75, 136.81, 136.90, 137.15, 138.26, 138.48, 140.25, 149.43, 164.88, 167.33. 31P NMR (162 MHz, CDCl3): delta -5.39. IR v (cm-1, neat): 3068, 2982, 1717, 1660, 1524, 1346, 1250, 729, 698. ESI HRMS for C35H29N2O5P: calcd (M+H) 589.1892, found 589.1901.

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various fields.

Reference£º
Article; Nelson, Brandon M.; Chavda, Mihir K.; Oliphant, Jonathan; King, Jalisa M.; Szczepura, Lisa F.; Hitchcock, Shawn R.; Tetrahedron Asymmetry; vol. 27; 20-21; (2016); p. 1075 – 1080;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: 4.3.25 methyl 2-phenyl-5-(4-fluorophenyl)thiazole-4-carboxylate (4e) A suspension of Pd(OAc)2 (10 mol percent), Ar3P (0.33 mmol or 0.75 mmol), AgOAc (3.0 mmol), TFA (1.0 mmol) and azole-4-carboxylates (0.5 mmol) in NMP (2 mL) was introduced to a Schlenk tube. After stirring at 120 C under argon for 24 h (reactions with 0.33 mmol of Ph3P), or 48 h (reactions with 0.75 mmol of Ph3P), the reaction mixture was diluted with ethyl acetate, and then filtered through a pad of Celite. Volatiles were removed in vacuo to give the crude products, which was purified by flash column chromatography on silica gel to afford pure arylated products Yield 118 mg (76percent). White solid, mp 126-128 ¡ãC; 1H NMR (300 MHz, CDCl3) delta 3.86 (s, 3H), 7.13 (t, J=8.6 Hz, 2H), 7.44-7.47 (m, 3H), 7.50-7.56 (m, 2H), 7.94-7.99 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) delta 166.1, 165.0, 162.5, 161.7, 145.3, 140.9, 132.6, 131.9, 131.8, 130.7, 129.0, 126.8, 126.3, 126.2, 115.5, 115.3, 52.3 ppm; IR (KBr) 2944, 1721, 1528, 1468, 1343, 1224, 1200, 1007, 843, 762, 689 cm-1; HRMS (ESI) calcd for [C17H12FNO2S+H]+ 314.0646, found 314.0649.

18437-78-0, The synthetic route of 18437-78-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Ziyuan; Zhou, Haipin; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan; Tetrahedron; vol. 69; 15; (2013); p. 3281 – 3286;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

29949-84-6, Tris(3-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 81 7-(3Methoxyphenyl)-1-(4-methylpiperazin-1-yl)naphthalene A mixture of 3-methoxy-1-bromobenzene (0.089 ml, 0.71 mmol), 7-trimethylstannyl-1-(4-methylpiperazin-1-yl)naphthalene (0.25 g, 0.64 mmol), bis-(acetonitrile) palladium chloride (0.0085 g, 0.032 mmol), tri(3-methoxyphenyl)phosphine (0.023 g, 0.064 mmol), and butylated hydroxytoluene (BHT, about 0.001 g, antioxidant) in dimethyl formamide (12 mL) was warned to 110 C. for 2 hours. The reaction was cooled to room temperature and diluted with 1 N aqueous lithium chloride (25 mL) and 1 N sodium hydroxide (2 mL); then extracted with ether (3*). The combined ether layer was washed with 1 N aqueous lithium chloride and brine. The organic phase was dried over calcium sulfate and concentrated. The residue was purified by flash chromatography on silica gel (1*2.5 inches). Elution proceeded as follows: 75% ethyl acetate/hexane, 200 mL, nil; 2% methanol/ethyl acetate 200 mL and 10% methanol/ethyl acetate, 200 mL, 0.084 g of an oil. This oil was further purified by kugelrohr distillation (1 mm Hg). The distillation proceeded as follows: 110-130 C., 0.014 g of a mixture of the title product and 7-methyl-1-(4-methylpiperazin-1-yl)naphthalene: 200-220 C. 0.062 g (23%) of the title compound as a yellow oil: 1H NMR delta 8.43 (incompletely resolved dd, J=1.2Hz, 1 h), 7.90 (d, J=9 Hz, 1 H), 7.74 (dd, J=2,8.5 Hz, 1 H), 7.58 (d, J=8 Hz, 1 H), 7.43 (sym m, 2 H), 7.34 (dt, J=1.5, 7.5 Hz, 1 H), 7.29 (5, J=2 Hz, 1 H), 7.14 (dd, J=1, 7.5 Hz, 1 H), 6.96 (ddd, J=1, 2.5,8 Hz, 1H), 3.92 (s, 3 H) 3.20 (br s, 4 H), 2.75 (br s, 4 H), 2.44 (s, 3 H). The product was dissolved in chloroform and HCL gas was bubbled through the solution to form the hydrochloride salt. Concentration of this solution to about 1 mL. at the boil and addition of about 1 mL of ether caused the white crystalline product to precipitate. The hydrochloride salt weighted 0.057 g: mp 236-238 C. Analysis calculated for C22H24N2O¡¤HCl: C, 71.63; H, 6.83; N, 7.59. Found: C, 71.31; H, 6.92; N, 7.59.

29949-84-6, The synthetic route of 29949-84-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chenard, Bertrand L.; Macor, John E.; Segelstein, Barbara E.; US2001/4669; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.932710-63-9,4-(Di-tert-butylphosphino)-N,N-dimethylaniline,as a common compound, the synthetic route is as follows.

932710-63-9, Take a dry 10L three-neck reaction flask, dry nitrogen is fully replaced and under nitrogen flow protection,Add 5.5 L of anhydrous tetrahydrofuran, stir and add 540 g of bis(acetonitrile)palladium dichloride.The obtained ligand di-tert-butyl-4-dimethylaminophenylphosphine was further reacted for 30 minutes, and a yellow solid was precipitated. After the reaction was continued for 9 hours at room temperature,After filtration, the filter cake was dipped in anhydrous tetrahydrofuran, drained and dried in a vacuum oven at 60 C.Obtaining a yellow crystalline powdery target product, namely dichlorodi-tert-butyl-(4-dimethylaminophenyl)phosphine palladium, yielding 1440 g to 1445 g,Elemental analysis showed that the product content exceeded 98.0%, the palladium content exceeded 15.0%, and the palladium calculated yield was 97.7% to 98.1%.

As the paragraph descriping shows that 932710-63-9 is playing an increasingly important role.

Reference£º
Patent; Shanxi Ruike New Materials Co., Ltd.; Zhang Wen; Zhao Lei; Hou Yunji; Cai Wanyu; (11 pag.)CN108659054; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24171-89-9,Tri(thiophen-2-yl)phosphine,as a common compound, the synthetic route is as follows.

2-Chloromethyl-3-hydroxypyridine hydrochloride (4) (0.40 g, 2.22 mmol) was added to a solution of tris- (2-thienyl)phosphine (0.93 g, 3.32 mmol) in acetonitrile (40 mL) and the mixture was refluxed for 12 h. Then, the solvent was evaporated in vacuo, the dry residue was dissolved in chloroform and washed with water. The aqueous layer was separated, dried in vacuo, and recrystallized from acetone. The yield was 0.24 g (24%), a white crystalline compound, m.p. 197-198 C. 1H NMR (DMSO-d6), d: 5.29 (d, 2 H, CH2P, J = 14.4 Hz); 7.22 (ABX-system, 1 H, 5-PyH, J1 = 8.0 Hz, J2= 4.6 Hz); 7.34 (ABX- system, 1 H, 4-PyH, J = 8.0 Hz); 7.49 (m, 3 H, P(2-thien)3 (thien means thienyl)); 7.91 (ABX-system, 1 H, 6-PyH, J = = 4.6 Hz); 7.97 (dd, 3 H, P(2-thien)3, J1 = 8.3 Hz, J2 = 3.4 Hz); 8.45 (t, 3 H, P(2-thien)3, J = 4.6 Hz); 10.83 (s, 1 H, OH). 13C NMR (DMSO-d6), d: 32.92 (d, CH2P, J = 64.3 Hz); 120.00 (d, Cthien, J = 112.2 Hz); 122.70 (s, CPyr); 124.62 (s, CPyr); 129.99 (d, Cthien, J = 16.2 Hz); 137.83 (d, Cthien, J = 3.9 Hz); 138.53 (s, CPyr); 140.51 (d, Cthien, J = 4.1 Hz); 141.98 (d, CPyr, J = 12.1 Hz); 152.36 (d, CPyr, J = 8.0 Hz). 31P NMR (DMSO-d6), d: 10.68. HRMS, found: m/z 388.0048 [M – 2 Cl – H]+. C18H16NOPS3Cl2. Calculated: [M – 2 Cl – H] = 388.0048., 24171-89-9

The synthetic route of 24171-89-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shtyrlin; Vafina; Pugachev; Khaziev; Nikitina; Zeldi; Iksanova; Shtyrlin, Yu. G.; Russian Chemical Bulletin; vol. 65; 2; (2016); p. 537 – 545; Izv. Akad. Nauk, Ser. Khim.; 2; (2016); p. 537 – 545,9;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate