Day: September 8, 2020

5931-53-3,5931-53-3, Diphenyl(o-tolyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

This procedure is in accordance with Csar et. al. [16] . Addition of nBuLi in hexanes (10.4 mmol, 1.60 M) to a 100-mL flask charged with CH3C6H4-o-PPh2 (2.40 g, 8.69 mmol), 30 mL ether, 3 mL pentane and 1.60 mL TMEDA resulted in precipitation of orange microcrystals, and the mixture was stirred at 23 C for 18 h. Filtration of the precipitate yielded the title compound as orange crystals (2.757 g, 80%). 1H NMR (C6D6): delta 1.66 (4H, s), 1.83 (12H, s), 6.23 (1H, t, 7 Hz), 6.77 (1H, t, 7 Hz), 7.03 (1H, m), 7.11 (3H, m), 7.18 (4H, m), 7.60 (4H, t, 7 Hz). 13C NMR (C6D6): delta 45.10, 56.26, 107.84, 120.28, 128.51, 128.55, 128.63, 129.36, 133.34, 134.66, 134.86, 137.25, 168.69. 31P NMR (C6D6): delta -15.52 (s).

As the paragraph descriping shows that 5931-53-3 is playing an increasingly important role.

Reference£º
Article; Jacobs, Brian P.; Wolczanski, Peter T.; MacMillan, Samantha N.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 132 – 139;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

819867-21-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.819867-21-5,Di-tert-butyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine,as a common compound, the synthetic route is as follows.

Potassium 3-((2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenylcarbamoyl)phenyl)ethynyl)-[1,2,4]triazolo[4,3-b]pyridazine-7-carboxylate Copper (I) iodide (396 mg, 4 mol.%) is added to a suspension of acetylene derivative (21.6 g, 52 mmol) and ethyl 3-bromo[1,2,4]triazolo[4,3-b]pyridazine-7-carboxylate (14.1 g, 52 mmol) in a mixture of degassed dry triethylamine (100 ml) and degassed dry THF (40 ml) and the reaction mixture is stirred for 10 min. Pd(Ph3P)2Cl2 (730 mg, 2 mol.%), PPh3 (1.1 g) and di-tert-butyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (100 mg) are then added, the reaction mixture is degassed twice and stirred at 65C for 130 h under inert atmosphere. Solvents are evaporated and the residue is purified chromatographically, using chloroform:methanol mixture of increasing polarity. The obtained product is dissolved in dry DMSO (50 ml). Water (1 ml) and potassium tert-butylate (0.6 g) are added and the mixture is stirred for 4 h. The desired product is purified on an ion exchange resin (16.3 g, 52%).

The synthetic route of 819867-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich; EP2743266; (2014); A2;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

24171-89-9, Tri(thiophen-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A toluene (50 mL) solution of Ru3(CO)12 (200 mg, 0.31 mmol) and PTh3 (88 mg, 0.31 mmol) was refluxed for 10 min during which time the color changed from yellow to orange. The solvent was removed under reduced pressure and the residue was subjected to TLC on silica gel. Elution with hexane/CH2Cl2 (9:1, v/v) gave several bands. The first band gave 1 (15 mg, 6%) while the second band gave Ru3(CO)9{mu-Th2P(C4H2S)}(mu-H) (4) (65 mg, 25%) as orange crystals after recrystallization from hexane/CH2Cl2 at 4 C. Anal. Calcd for C21H9O9P1Ru3S3: C, 30.18; H, 1.09%. Found: C, 30.35; H, 1.12%. IR (nuCO, CH2Cl2): 2085 s, 2060 s, 2034 s, 2022 s, 2014 m, 1998 w cm-1. 1H NMR (CDCl3): delta 7.61 (m, 1H), 7.43 (m, 1H), 7.72 (m, 1H), 7.32 (m, 2H), 7.23 (m, 2H), 7.16 (m, 2H), -17.70 (d, J = 20.5 Hz, 1H). 31P{1H} NMR (CDCl3): delta 17.82 (s, 1P). FAB MS: m/z 837 (M+). The third band afforded Ru3(CO)8{mu-Th2P(C4H2S)(PTh3)(mu-H) (5) (26 mg, 8%) as pink crystals from hexane/CH2Cl2 at 4 C. Anal. Calcd for C32H18O8P2Ru3S6: C, 35.32; H, 1.67%. Found: C, 35.50; H, 1.70%. IR (nuCO, CH2Cl2): 2072 s, 2033 s, 2020 s, 2003 w, 1995 w, 1971 m, 1963 w cm-1. 1H NMR (CDCl3): delta 7.93 (m, 1H), 7.72 (m, 1H), 7.53 (m, 3H), 7.34 (m, 1H), 7.22 (m, 1H), 7.16 (d, J = 5.0 Hz, 1H), 7.00 (m, 3H), 6.76 (m, 3H), 6.72 (d, J = 5.0 Hz, 1H), 6.43 (m, 1H), 6.34 (m, 1H), -17.03 (dd, J = 17.2, 8.8 Hz, 1H). 31P{1H} NMR (CDCl3): delta 16.20 (d, J = 32.2 Hz, 1P), 6.50 (d, J = 32.2 Hz, 1P). FAB MS: m/z 1089 (M+)., 24171-89-9

24171-89-9 Tri(thiophen-2-yl)phosphine 90384, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Uddin, Md Miaz; Begum, Noorjahan; Ghosh, Shishir; Sarker, Jagodish C.; Tocher, Derek A.; Hogarth, Graeme; Richmond, Michael G.; Nordlander, Ebbe; Kabir, Shariff E.; Journal of Organometallic Chemistry; vol. 812; (2016); p. 197 – 206;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

6372-42-5, Cyclohexyldiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6372-42-5

General procedure: A 20mL scintillation vial was charged with 1equiv of NCr(NiPr2)2I (1) [42], 110 acetonitrile (3mL), and a Teflon-coated stir bar. This mixture was stirred at room temperature giving a dark red-orange solution. Separately, a solution of 111 AgSbF6 (1equiv) was prepared in acetonitrile (1-2mL). The AgSbF6 solution was then added dropwise to the stirred solution of 1. Upon addition, copious amounts of off-white precipitate formed, and the solution became dark brown. The resultant mixture was stirred for 20min after complete addition of the Ag solution. The mixture was then filtered over Celite to remove the precipitate. The dark brown solution of 2 collected was once again stirred at room temperature and a solution of PR3 (1-2equiv) in acetonitrile (1-2mL) was added. (1equiv of the phosphine was used if it was a solid or high-boiling liquid phosphine that is difficult to remove by recrystallization. 2equiv of phosphine were used if PR3 is a low-boiling liquid easily removed in vacuo.) Upon addition of PR3, the solution quickly became yellow-orange. The reaction solution was stirred for 1h at room temperature. The volatiles were then removed in vacuo to give a dark residue. This residue was rinsed with small aliquots of cold Et2O (3¡Á1mL) to remove any unreacted 1. The residue was once more dried in vacuo. The residue was dissolved in a minimal amount of CH2Cl2 or CHCl3 and layered with Et2O or pentane. The layered solution was then stored overnight at -35C to yield yellow-orange X-ray quality crystals.

6372-42-5 Cyclohexyldiphenylphosphine 80756, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Aldrich, Kelly E.; Billow, Brennan S.; Staples, Richard J.; Odom, Aaron L.; Polyhedron; vol. 159; (2019); p. 284 – 297;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13991-08-7,1,2-Bis(diphenylphosphino)benzene,as a common compound, the synthetic route is as follows.

Under argon atmosphere, 1,2-bis(diphenylphosphino)benzene (91.7 mg, 0.205 mmol) was added to 5 mL of the suspension of silver(I) tetrafluoroborate (40.0 mg, 0.205 mmol) in dry dichloromethane, and the mixture was stirred at room temperature for one hour. Then, 2,2′-biquinoline (52.7 mg, 0.205 mmol) was added to the reaction solution, which was stirred at room temperature for another one hour. The pale yellow reaction solution was filtrated, and the filtrate was concentrated, subjected to recrystallization by slow diffusion of chloroform-ether, and dried to provide 171 mg of the pale yellow solid complex. The result of elemental analysis for the obtained complex is shown in Table 2-2, and the composition ratio of the complex was obtained. The present complex corresponds to the above composition formula (5).

13991-08-7, 13991-08-7 1,2-Bis(diphenylphosphino)benzene 498379, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP2360162; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50777-76-9, General procedure: To a mixture of 2-(diphenylphosphino)benzaldehyde(500 mg, 1.72 mmol) and the appropriate amine(1.81 mmol) was added formic acid (1 drop) in MeOH(5 mL). The reaction was allowed to proceed at RT for18 h, at which point the iminophosphine pro-ligand was collected by suction filtration as a pale yellow precipitate. Spectroscopic NMR data were collected in CDCl3 as the pro-ligands decompose in wet DMSO-d6. The spectroscopically pure pro-ligands were used as prepared to make the corresponding platinum(II) complexes. (E)-N-(2-(Diphenylphosphino)benzylidene)-2-methoxyaniline(2) Yield: 449 mg (66percent); m.p.: 108?109 C.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; St-Coeur, Patrick-Denis; Adams, Meghan E.; Kenny, Bryanna J.; Stack, Darcie L.; Vogels, Christopher M.; Masuda, Jason D.; Morin, Pier Jr.; Westcott, Stephen A.; Transition Metal Chemistry; vol. 42; 8; (2017); p. 693 – 701;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17261-28-8, General procedure: The 1a? (439 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and trifluoroacetic acid (1 ml) was dropwise added at 0 ¡ãC. Then the reaction mixture was stirred for 18 h at room temperature. All volatile compounds were removed in vacuo and the residue was dissolved in water and treated with the saturated Na2CO3 solution. The resulting mixture was extracted with CH2Cl2 (3x) and the combined organic layers were dried over Na2SO4. After filtration and then evaporation of the solvent, the crude free amine was obtained without purification for the next step. To the solution of the free amine in CH2Cl2 (8 ml) was added O-(benztriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (HBTU, 417 mg, 1.1 mmol), followed by the addition of diisopropylethylamine (367 uL, 2.2 mmol) and 2-(diphenylphosphino)benzoic acid (306 mg, 1 mmol), The reaction mixture was then stirred for 6 h at room temperature. The mixture was combined with CH2Cl2 and water, and the organic layer was separated, washed with saturated sodium bicarbonate (2x), and dried overNa2SO4. The solvent was removed in vacuo to afford the crude product as a colourless oil, which was purified by flash chromatography (20percent EtOAc in hexanes) yielding the precat. 1a as a white solid (514 mg, 82percent).

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Zheng, Xiaojun; Deng, Qifu; Hou, Qinglin; Zhang, Kaiqiang; Wen, Pushan; Hu, Shunqin; Wang, Haifei; Synthesis; vol. 50; 12; (2018); p. 2347 – 2358;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13440-07-8,Di(naphthalen-1-yl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: A mixture of quinone monoketal (0.6 mmol), H-phosphine oxide(0.5 mmol), and catalyst (20 mol% of H2O for allylic substitution,20 mol% of Et3N for 1,6-substitution) was dissolved in toluene underN2 atmosphere, stirred at 100 C or 80 C for 12 h. Uponcompletion of the reaction, the mixture was concentrated undervacuum. Removal of the solvent under a reduced pressure gave thecrude product; pure product was obtained by passing the crudeproduct through a short silica gel column using Hexane/EtOAc(2:1-5:1) as eluent., 13440-07-8

13440-07-8 Di(naphthalen-1-yl)phosphine oxide 23110917, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Xiong, Biquan; Wang, Gang; Zhou, Congshan; Liu, Yu; Yang, Chang-An; Zhang, Panliang; Tang, Kewen; Zhou, Quan; Journal of Organometallic Chemistry; vol. 885; (2019); p. 21 – 31;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6163-58-2,Tri-o-tolylphosphine,as a common compound, the synthetic route is as follows.

6163-58-2, (4E)-5-(3-Pyridyl)-4-penten-2-ol A mixture of 3-bromopyridine (7.50 g, 47.46 mmol), 4-penten-2-ol (4.90 g, 56.96 mmol), palladium(II) acetate (106 mg, 0.47 mmol), tri-o-tolylphosphine (575 mg, 1.89 mmol), triethylamine (28.4 mL, 204.11 mmol) and acetonitrile (25 mL) were heated in a sealed glass tube at 140 C. for 14 h. The reaction mixture was cooled to ambient temperature, diluted with water, and extracted with chloroform (3*200 mL). The combined chloroform extracts were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a pale-yellow oil (7.50 g, 81.0 %).

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Targacept, Inc.; US6492399; (2002); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, General procedure: To a dichloromethane solution (15 mL) of 2-diphenylphosphinobenzaldehyde (ca. 3 mmol) was added an equimolar amount of the appropriate substituted amine. An excess of magnesium sulphate was also added to the reaction mixture to remove the water by-product. The reaction was left to stir at room temperature for 16 h, after which time the magnesium sulphate was filtered off and the solvent removed from the filtrate in vacuo to give a yellowe orange oil. The oily crude products of ligands 1a-1f were solidified by dissolving the oil in hot hexane, followed by quick hot filtration of the liquid product. The resultant solution was then cooled at -16 ¡ãC overnight to give an off-white powder, which was filtered and dried in vacuo.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Mogorosi, Mokgolela M.; Mahamo, Tebello; Moss, John R.; Mapolie, Selwyn F.; Slootweg, J. Chris; Lammertsma, Koop; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 696; 23; (2011); p. 3585 – 3592;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate