With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.
50777-76-9, 2-(Diphenylphosphino)benzaldehyde (0.101g, 0.346mmol) was added to methanol (15mL), followed by the addition of benzene-1,4-diamine (0.0186g, 0.172mmol). The reaction mixture was refluxed at 68¡ãC for 6h, and stirred overnight at ambient temperature to yield a yellow suspension. A light yellow powder was collected by suction filtration, washed with hexane and dried in vacuo. Yield: 0.0985g, 88percent. Melting point: 206.4?210.4¡ãC. 1H NMR (399.95MHz, CDCl3): delta (ppm)=9.06 (d, 4JHP=5.10Hz, 2H, HC=N); 8.19 (m, 2H, Hd); 7.45 (t, 3JHH=7.80Hz, 2H, Hc); 7.33 (m, 22H, PPh2 & Hb); 6.94 (m, 2H, Ha); 6.88 (s, 4H, He). 31P NMR (162.00MHz, CDCl3): delta (ppm)=?22.2. FT-IR (KBr, cm?1): nu=3435 (w, N?H); 1610 (m, C=N). MS-EI+: m/z 653 ([M]+, 40percent); 652 ([M?H]+, 94percent).
The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Adams, Muneebah; De Kock, Carmen; Smith, Peter J.; Chibale, Kelly; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 736; (2013); p. 19 – 26;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate