Day: September 7, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, 2-(Diphenylphosphino)benzaldehyde (0.101g, 0.346mmol) was added to methanol (15mL), followed by the addition of benzene-1,4-diamine (0.0186g, 0.172mmol). The reaction mixture was refluxed at 68¡ãC for 6h, and stirred overnight at ambient temperature to yield a yellow suspension. A light yellow powder was collected by suction filtration, washed with hexane and dried in vacuo. Yield: 0.0985g, 88percent. Melting point: 206.4?210.4¡ãC. 1H NMR (399.95MHz, CDCl3): delta (ppm)=9.06 (d, 4JHP=5.10Hz, 2H, HC=N); 8.19 (m, 2H, Hd); 7.45 (t, 3JHH=7.80Hz, 2H, Hc); 7.33 (m, 22H, PPh2 & Hb); 6.94 (m, 2H, Ha); 6.88 (s, 4H, He). 31P NMR (162.00MHz, CDCl3): delta (ppm)=?22.2. FT-IR (KBr, cm?1): nu=3435 (w, N?H); 1610 (m, C=N). MS-EI+: m/z 653 ([M]+, 40percent); 652 ([M?H]+, 94percent).

The synthetic route of 50777-76-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Adams, Muneebah; De Kock, Carmen; Smith, Peter J.; Chibale, Kelly; Smith, Gregory S.; Journal of Organometallic Chemistry; vol. 736; (2013); p. 19 – 26;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound NF-OH (50 mg, 0.16 mmol) and 2-(diphenylphosphino)benzoic acid (161.7 mg, 0.528 mmol) were dissolved in dichloromethane and then added4-(Dimethylamino)-pyridine-4-toluenesulfonate (141.3 mg, 0.48 mmol) and N,N’-diisopropylcarbodiimide (60.6 mg, 0.48 mmol). The reaction system was stirred at room temperature for 5 hours under argon gas. It is then extracted with ethyl acetate and the organic phase is separated.Drying over anhydrous sodium sulfate and column chromatography gave the product: NF-P., 17261-28-8

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Hubei University; Wang Feiyi; Yang Guichun; Chai Yun; Chen Zuxing; Lu Cuifen; Nie Junqi; Ma Chao; (12 pag.)CN109608495; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13440-07-8, Di(naphthalen-1-yl)phosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 2-methoxyphenylacetylene (0.066 g, 0.5 mmol) to the reaction flask.Dinaphthylphosphorus (0.30 g, 1 mmol),CuCl (0.01 g, 0.1 mmol), di-tert-butyl peroxide(0.45 g, 3 mmol),And N-methylpyrrolidone (2 mL),70oC reaction;TLC tracks the reaction until it is completely over;The crude product obtained after the reaction is separated by column chromatography(Ethyl acetate: petroleum ether = 1:1) gave the desired product (yield: 73%)., 13440-07-8

The synthetic route of 13440-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nantong Textile Silk Industrial Technology Institute; Soochow University (Suzhou); Zou Jianping; Tao Zekun; Lv Shuaishuai; Li Chengkun; Li Jianan; (12 pag.)CN109096336; (2018); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

4559-70-0, Diphenylphosphine oxide is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of dicyclohexylcarbonyl peroxide (127 mg, 0.5 mmol), copper oxide (7.9 mg, 0.1 mmol), 3,4,7,8-tetramethyl-1,10-phenanthroline (11.8 mg, 0.05 mmol), dichloromethane (1 mL) and diphenylphosphoryl (50.5 mg, 0.25 mmol), stirred at 40 C, and monitored by TLC until the end of the reaction;The crude product obtained after the completion of the reaction was separated by column chromatography ( petroleum ether: acetone = 4:1) to give the desired product (yield: 77%).

4559-70-0, As the paragraph descriping shows that 4559-70-0 is playing an increasingly important role.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Tao Zekun; (13 pag.)CN110229187; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50777-76-9,2-(Diphenylphosphino)benzaldehyde,as a common compound, the synthetic route is as follows.

50777-76-9, In a Schlenk tube under nitrogen, 2-amino-2-deoxy-1,3,3,6-tetra-O-trimethylsilyl-alpha-d-glucopyranose7 (1?g, 2.1?mmol) and ? 2-(diphenylphosphino)benzaldehyde (621?mg, 2.1?mmol) were stirred in ? toluene (40?mL) at 60?¡ãC for 12?h. After concentration, the residue was purified by flash chromatography on silica gel, eluting with ethyl acetate/hexane, 5:1 (Rf?=?0.82). Yellow oil, 1.2?g, 77percent yield, [alpha]20D=+41.6 [alpha]D20=+41.6 (c 0.5, CHCl3); 1H NMR (600?MHz, CDCl3): delta?=?0.10, 0.18, 0.25, 0.31 (4s, 36H, 4OSi(CH3)3), 3.25 (dd, 1H, J?=?9.4, 3.2, H-2), 3.71 (dd, 1H, J?=?9.6, 8.6, H-4), 3.84?3.90 (m, 2H, H-6, H-6?), 3.99 (ddd, 1H, J?=?9.6, 3.7, 2.8, H-5), 4.41 (dd, 1H, J?=?9.4, 8.6, H-3), 4.80 (d, 1H, J?=?3.2, H-1), 7.35?7.52 (m, 13H, C6H5), 8.34?8.36 (m, 1H, C6H5), 9.19 (d, 1H, J?=?6.1, NCH). 13C NMR (150?MHz, CDCl3): delta?=?0.0, 0.2, 1.1, 1.5 (4OSi(CH3)3), 62.5 (C-6), 72.5, 72.8 (C-4, C-5), 74.6 (C-2), 77.0 (C-3), 95.4 (C-1), 127.3 (d, J?=?4.4, C6H5), 128.4, 128.7, 128.8, 129.0, 129.1, 130.6, 133,7, 133.9, 134.0, 134.1, 134.2, 134.3, (C6H5), 136.2 (d, J?=?5,6, C6H5), 136.7 (d, J?=?9.9, C6H5), 138.0 (d, J?=?18.8, C6H5), 139.7 (d, J?=?17.8, C6H5), 161.1 (d, J?=?27.5, NCH). C37H58NO5PSi4 (740.18): calcd C 60.04, H 7.90, N 1.89; found C 60.01, H 7.86, N 1.96.

As the paragraph descriping shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Olszewska, Beata; Szulc, Izabela; Kryczka, Boguslaw; Kubiak, Agnieszka; Porwanski, Stanislaw; Zawisza, Anna; Tetrahedron Asymmetry; vol. 24; 4; (2013); p. 212 – 216;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The solutions of a (0.0256 g, 0.1 mmol)ofH2dz in 10 cm3 of methanol, (0.1 mmol, 0.0273 g)of NiCl2.6H2O in 10 cm3 of methanol) and (0.0554 g,0.1mmol of 1,1′-bis(diphenyl phosphine) ferrocene(dppf) were mixed and refluxed at 55oC for 2 h togive red-brown colored precipitate and the solutionswas filtered and finally it was dried in an open air.Yield= 72percent, d.p= 265¡ãC. Anal. Calc. percent for C47 H41 ClN4 P2 Ni S Fe: C, 62.32; H, 4.56; N, 6.19, S, 3.54, Ni,6.48, Cl,3,91 . Found percent: C, 61.83.7; H, 4.72; N, 5.94, S; 2.89,Ni; 6.93, Cl, 3.98. The Proposed GeometricalStructure shown in Figure 1., 12150-46-8

As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Mohamad, Hikmat Ali; Oriental Journal of Chemistry; vol. 34; 4; (2018); p. 1919 – 1925;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

564483-19-8, Di-tert-butyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

564483-19-8, Step 3: 1-(4-(1-(4-Methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]inden-4-ol 4-Bromo-1-(4-(1-(4-methoxybenzyl)-1H-1,2,4-triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]indene (1.3 g, 3.31 mmol), 2-di-t-butylphosphino-2′,4′,6′-tri-i-propyl-1,1′-biphenyl (150 mg, 0.353 mmol), tris(dibenzylideneacetone)dipalladium(0) (170 mg, 0.186 mmol), and potassium hydroxide (270 mg, 4.81 mmol) were suspended in 1,4-dioxane (15 mL) and water (1.5 mL) under an atmosphere of nitrogen and the mixture was heated at 100 C. for 7 h. The reaction system was diluted with water and extracted with DCM. The organic phase was dried over magnesium sulfate and evaporated in vacuo. The crude product was purified via flash chromatography on silica gel (solvent gradient: 0-10% methanol in DCM) to yield 760 mg (67%) of the title compound as a yellow solid. LCMS (ESI): [M+H]+=468.

As the paragraph descriping shows that 564483-19-8 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.

General procedure: DPEphos (0.1077 g, 0.2 mmol) and dppe (0.0396 g, 0.1 mmol) were dissolved in the mixture of CH2Cl2, CH3OH (10 ml, v/v = 1/1), adding AgCl (0.0286 g, 0.2 mmol) and DMF (2 ml) into the reaction flask. Stirring for 12 h, and then filtrating, the filtrate was slow evaporated at ambient temperature. 16 days later, colorless block shaped crystals were obtained. Yield: 22.5percent (0.0427 g). Anal. Calc.for (C103H95Ag2Cl2NO5P6): C, 65.14; H, 5.01; N, 0.74. Found: C,65.45; H, 4.94; N, 0.74percent. IR (cm-1, KBr pellets): 3436br, 3050m, 2924m, 2853m, 1950w, 1676vs, 1583m, 1565m, 1480s, 1461s, 146vs, 1385s, 1330m, 1311m, 1257s, 1223s, 1184m, 1161m, 1127m, 1094s, 1070s, 1026m, 997m, 878m, 801m, 747s, 696s,543w, 529w, 506s, 481m, 470m, 433w, 420w. 1H NMR (600 MHz,CDCl3): 2.90 (d, 4H, dppe), 3.48 (s, 6H, DMF), 6.76?7.28 (m, 76H,Ph), 8.02 (s, 1H, DMF). 31P {1H}NMR (243 MHz, CDCl3): 5.7 (br,dppe), 11.9 (br, d, JAg?P = 286.8 Hz, DPEphos)., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Gao, Sen; Li, Zhong-Feng; Liu, Min; Jin, Qiong-Hua; Chen, Yu; Deng, Zi-Jun; Zhang, Zhen-Wei; Zhang, Cun-Li; Polyhedron; vol. 83; (2014); p. 10 – 15;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13689-20-8,Cyclohexyldiphenylphosphine oxide,as a common compound, the synthetic route is as follows.

Add cyclohexyldiphenylphosphine (28.4 mg, 0.1 mmol), copper triflate (3.6 mg, 0.01 mmol),Tetramethyldisilazane (26.7 mg, 0.2 mmol) and toluene (1 mL), the mixture was stirred at 80oC;TLC follows the reaction to completion;The crude product obtained after the reaction was recrystallized from toluene to obtain the target product (yield 82%). The analytical data of the product are as follows:, 13689-20-8

13689-20-8 Cyclohexyldiphenylphosphine oxide 83664, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Li Chengkun; Yan Xuping; Wang Yijie; (14 pag.)CN110256489; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146960-90-9,1,1′-Bis(dicyclohexylphosphino)ferrocene,as a common compound, the synthetic route is as follows.

1,1′-Bis(dicyclohexylphosphino)ferrocene (dcpf) (0.578 g, 1.0 mmol) was added to a solution of gold(I) cyanide (0.223 g, 1.0 mmol) in 30 mL CH3OH:CH2Cl2 (50:50 V/V) mixture at room temperature. The resultant suspension was refluxed with stirring under nitrogen atmosphere for 24 h. Slowly, the colour of the solution changed from light yellowish orange to dark yellowish orange colour. The resulting solution was evaporated to dryness to give a yellowish orange solid which was then extracted with dichloromethane (20 mL). The addition of hexane (100 mL) to this solution led to yellow needle shaped diffraction quality crystals. These were separated and washed with hexane and dried. Yield: (0.768 g, 75 %). Anal. Calc. for C36H52N2P2Au2Fe: C, 42.19; H, 5.08; N,2.73. Found: C, 42.32; H, 5.32; N, 2.94. IR (cm-1, KBr): n 3401, 2930, 2850, 2360, 2340, 2151(CN), 1730, 1440, 1240, 1164, 1110, 1032, 868, 630, 490. 1H NMR (delta ppm, 400 MHz, CDCl3, 298 K), 4.40 (s, 4H, C5H4), 4.22 (s, 4H, C5H4), 2.71-1.22 (m, 44H, Cy). 31P{1H}: delta 41.6 (s) (Sharp). UV/Vis: lambdamax (epsilon [dm3 mol-1 cm-1]) 267 (10,727), 460 (23,595). ESI-MS (m/z): 1024.1 (M+)., 146960-90-9

146960-90-9 1,1′-Bis(dicyclohexylphosphino)ferrocene 44558250, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Trivedi, Manoj; Bhaskaran; Singh, Gurmeet; Kumar, Abhinav; Rath, Nigam P.; Journal of Organometallic Chemistry; vol. 758; (2014); p. 9 – 18;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate