With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
17261-28-8, (R, R) -cyclohexanediamine (1.26 g, 11.0 mmol), 2-diphenylphosphine benzoic acid (6.74 g), DCM (100.0 mL) were added successively under nitrogen, followed by sequential EDCI (4.22 g, 22.0 mmol) and DMAP (1.34 g, 11.0 mmol) were stirred at room temperature for 6 hours, quenched with 1 N aqueous hydrochloric acid and extracted with DCM (3 x 50.0 mL). The organic phases were combined, Dried over magnesium sulfate and spin-dried to give the indicated product Trostligand;(17.4 mL, 35percent w / w) was added at 0 ¡ã C, stirred at 0 ¡ã C for 4 hours, diluted with water (100.0 mL), and the mixture was stirred at 0 ¡ã C, The aqueous phase was extracted with DCM (3 x 50.0 mL) and the combined organic phases were dried over anhydrous magnesium sulphate and spin-dried to give the indicated product as a white solid, 4.34 g, 86percent yield.
The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES; SHI, YIAN; HUANG, HU; PAN, HONGJIE; CAI, YUDONG; LIU, MAO; TIAN, HUA; (24 pag.)CN104447606; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate