With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.
17261-28-8, (2)Compound 2 (156 mg, 0.5 mmol), diphenyl phthalic acid (184 mg, 0.6 mmol), dicyclohexylcarbodiimide (288 mg, 1.4 mmol),4-Dimethylaminopyridine (61.1 mg, 0.5 mmol) was mixed with dichloromethane (anhydrous grade).The reaction was stirred at room temperature, and monitored by TCL plate until Compound 2 disappeared, and the reaction was carried out for 12 h;The resulting product is subjected to suction filtration,Wash with saturated brine and extract three times with dichloromethane.Purified by silica gel column chromatography,The eluent used was dichloromethane and methanol (mound ratio of dichloromethane to methanol was 15:1).A brownish green solid of 195 mg was obtained.The calculated yield is 65%;
17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.
Reference£º
Patent; Inner Mongolia University; Wang Jianguo; Jiang Guoyu; Zhu Wenping; (19 pag.)CN109796493; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate