Day: September 4, 2020

6163-58-2, Tri-o-tolylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6163-58-2, c Methyl (+-)-3-carbomethoxy-4-[2-bis(tert-butoxycarbonyl)aminomethyl-4-methoxyphenyl ]-3-butenoate A 500 mL flask was charged with 3-bis(tert-butoxycarbonyl)aminomethyl-4-bromoanisole (15 g, 36 mmol), dimethyl itaconate (7.5 g, 47 mmol), tri-o-tolylphosphine (1 g, 3 mol), palladium acetate (0.4 g, 2 mmol), diisopropylethylamine (12.8 mL, 72 mmol), and propionitrile (150 mL). The mixture was purged with argon (several evacuation/argon flush cycles), then was heated to reflux under argon for 1 hr. The reaction was allowed to cool to RT, then was poured into ice-cold ethyl ether (500 mL). The resulting precipitate was removed by filtration and the filtrate was concentrated. The residue was purified by chromatography on silica gel (10% – 20% ethyl acetate in hexane) to give the title compound (11.8 g, 66%) as a pale yellow oil: 1H NMR (CDCl3) delta7.94 (s, 1 H), 7.15 (d, J =8.1 Hz, 1 H)), 6.77 (d, J=8.1 Hz, 1 H), 6.76 (s, 1 H), 4.73 (s, 2 H), 3.81 (s, 3 H), 3.79 (s, 3 H), 3.71 (s, 3 H), 3.38 (s, 2 H), 1.45 (s, 18 H).

As the paragraph descriping shows that 6163-58-2 is playing an increasingly important role.

Reference£º
Patent; Heerding, Dirk; US2001/14737; (2001); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ru(acac)2(CH3CN)2 (0.100 g, 0.262 mmol) and 1,1-bis(diphenylphosphino)ferrocene (dppf) (0.145 g, 0.262 mmol) were dissolved in 40 mL of toluene and refluxed under an argon atmosphere for 8 h. After the refluxing was complete, the solvent was removed under vacuum. Slow diffusion of petroleum ether vapor into a CH2Cl2 solution of Ru(acac)2(dppf) afforded the desired yellow crystal. Yield 91percent, 0.203 g. Anal. Calcd (percent) for RuFeC44H42O4P2: C, 61.91; H, 4.96. Found: C, 61.85; H, 4.99. ESI-MS (CH3CN): m/z 854.1 [M+H]+. IR (cm-1): 3058 (m), 2922 (s), 2848 (m), 1747 (m),1573 (s), 1516 (s), 1435 (m), 1400 (m), 1261 (w), 1094 (w), 1024(w), 816 (w), 748 (m), 690 (s), 615 (w), 551 (s). 1H NMR (600 MHz, CDCl3) (delta/ppm): 7.76?7.73 (m, 4 phenyl protons);7.34?7.32 (m, 6 phenyl protons); 7.29?7.24 (m, 6 phenyl protons);7.17?7.14 (m, 4 phenyl protons); 4.82 (s, 2H, CH(acac)); 4.74, 4.35,4.32, 4.19 (four singlets, 8H, (C5H4)2Fe); 1.70 (s, 6H, CH3(acac));1.49 (s, 6H, CH3(acac)). 31P (delta/ppm): 52.45 (s).

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Gao, Li-bin; Sun, Xin-zhi; Li, Lin; Li, Jian-zhong; Polyhedron; vol. 124; (2017); p. 200 – 205;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

855-38-9, Tris(4-methoxyphenyl)phosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,855-38-9

EXAMPLE 14 N-(4-Fluorophenyl)-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine-2-carboxamide The procedure was as described in Example 4. 4.92 g of crude product was obtained in the form of a light yellow solid from 3.47 g (12.5 mmol) of 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine, 2.08 g (18.7 mmol) of 4-fluoroaniline, 1.46 g (13.8 mmol) of sodium carbonate, 5.6 mg (25 mumol) of palladium(II) acetate and 0.13 g (375 mumol) of tris(4-methoxyphenyl)phosphine in 12.5 ml of xylene after 21 hours at 150 C. under a CO pressure of 19 bar (GC: complete conversion). It was purified by recrystallization from methylcyclohexane. The yield was 3.97 g (84.4 percent) of light beige crystals. Other data concerning the product was: M.p.: 138-139 C. 1 H NMR (CDCl3): delta=3.85 (s, 3H); 6.41 (s, 1H); 7.06 (m, 2H); 7.29 (d, J=8.1 Hz, 1H); 7.59 (m, 2H); 8.05 (t, J=8.1 Hz, 1H); 8.14 (d, J=8.1 Hz, 1H); 9.28 (bs, 1H).

As the paragraph descriping shows that 855-38-9 is playing an increasingly important role.

Reference£º
Patent; Lonza AG; US5900484; (1999); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (R, R) -cyclohexanediamine (1.26 g, 11.0 mmol), 2-diphenylphosphine benzoic acid (6.74 g), DCM (100.0 mL) were added successively under nitrogen, followed by sequential EDCI (4.22 g, 22.0 mmol) and DMAP (1.34 g, 11.0 mmol) were stirred at room temperature for 6 hours, quenched with 1 N aqueous hydrochloric acid and extracted with DCM (3 x 50.0 mL). The organic phases were combined, Dried over magnesium sulfate and spin-dried to give the indicated product Trostligand;(17.4 mL, 35percent w / w) was added at 0 ¡ã C, stirred at 0 ¡ã C for 4 hours, diluted with water (100.0 mL), and the mixture was stirred at 0 ¡ã C, The aqueous phase was extracted with DCM (3 x 50.0 mL) and the combined organic phases were dried over anhydrous magnesium sulphate and spin-dried to give the indicated product as a white solid, 4.34 g, 86percent yield.

The synthetic route of 17261-28-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; INSTITUTE OF CHEMISTRY, CHINESE ACADEMY OF SCIENCES; SHI, YIAN; HUANG, HU; PAN, HONGJIE; CAI, YUDONG; LIU, MAO; TIAN, HUA; (24 pag.)CN104447606; (2016); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

2622-14-2, Tricyclohexylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Reactions for each substrate were run in triplicate. For substrate oxidation reactions, either 21 mg pyridine-N-oxide (220 mumol) or 27 mg of x-PVP-N-oxide (220 mumol) was added to 100 mumol of substrate in 500 muL of acetonitrile in a J-Young NMR tube and sealed in the glovebox. The reactions were taken out of the glovebox and heated at 110 C for 24 hours. After cooling to room temperature, the solvent was transferred to a clean vial and 100 muL of a 0.333 M of 2-adamantanone solution in chloroform was added as an internal standard. The solution volume was diluted to 2.0 mL with chloroform, filtered, and analyzed by GC/FID. Product peaks were identified by comparison to GC/FID chromatograms of authentic samples of the expected products, and percent conversions were determined by comparison to 2-adamantanone as a standard., 2622-14-2

Big data shows that 2622-14-2 is playing an increasingly important role.

Reference£º
Article; Bauer, Anna M.; Ramey, Erin E.; Oberle, Kjersti G.; Fata, Gretchen A.; Hutchison, Chloe D.; Turlington, Christopher R.; Tetrahedron Letters; vol. 60; 43; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17261-28-8,2-(Diphenylphosphino)benzoic acid,as a common compound, the synthetic route is as follows.

17261-28-8, (2)Compound 2 (156 mg, 0.5 mmol), diphenyl phthalic acid (184 mg, 0.6 mmol), dicyclohexylcarbodiimide (288 mg, 1.4 mmol),4-Dimethylaminopyridine (61.1 mg, 0.5 mmol) was mixed with dichloromethane (anhydrous grade).The reaction was stirred at room temperature, and monitored by TCL plate until Compound 2 disappeared, and the reaction was carried out for 12 h;The resulting product is subjected to suction filtration,Wash with saturated brine and extract three times with dichloromethane.Purified by silica gel column chromatography,The eluent used was dichloromethane and methanol (mound ratio of dichloromethane to methanol was 15:1).A brownish green solid of 195 mg was obtained.The calculated yield is 65%;

17261-28-8 2-(Diphenylphosphino)benzoic acid 87021, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Inner Mongolia University; Wang Jianguo; Jiang Guoyu; Zhu Wenping; (19 pag.)CN109796493; (2019); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D1 (0.12 g, 0.4 mmol), copper powder (0.032 g, 0.5 mmol), and POP (0.22 g, 0.4 mmol) werereacted in CH3CN (5 mL) at 60 ¡ãC for 24 h. The resulting mixture was filtered through a plugof Celite and concentrated to 1 mL. Addition of Et2O (10 mL) to the filtrate afforded a paleyellow precipitate, which was collected, washed with Et2O, and recrystallized with ethanol.Yield: 0.29 g, 80percent. 1H NMR (400 MHz, DMSO) delta (ppm): 8.32 (s, 1H), 8.02 (t, J = 6.4 Hz, 3H), 7.53(s, 1H), 7.43?7.37 (m, 5H), 7.33 (d, J = 6.9 Hz, 5H), 7.26 (d, J = 6.7 Hz, 4H), 7.17?7.05 (m, 9H), 6.92 (s, 4H), 6.66 (s, 2H), 3.44 (s, 3H); 13C NMR (101 MHz, DMSO) delta (ppm): 157.93, 148.14,140.51, 133.66, 132.91, 132.38, 132.10, 131.80, 131.61, 131.42, 129.82, 128.73, 125.00, 124.72,123.83, 122.44, 120.47, 116.92, 112.23, 37.52; 31P NMR (162 MHz, DMSO) delta (ppm): ?8.80 (s),?143.57 (quint). HRMS (m/z, ESI+): Calcd for C45H37CuN3OP2 ([M]+) 760.1708; found 760.1723.Anal. Calcd for C45H37CuF6N3OP3 (906.25): C, 59.64; H, 4.12; N, 4.64. Found: C, 59.97; H, 4.47;N, 4.52., 166330-10-5

The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Shaobo; Xu, Shengxian; Wang, Jinglan; Zhao, Feng; Xia, Hongying; Wang, Yibo; Journal of Coordination Chemistry; vol. 70; 4; (2017); p. 584 – 599;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18437-78-0,Tris(4-fluorophenyl)phosphine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of Ru3(CO)10(arphos) (52.3mg, 0.051mmol) and PCy3 (14.0mg, 0.051mmol) was heated in refluxing hexane (25ml) for 1h. Completion of the reaction was monitored by TLC. The solvent was removed under reduced pressure. The reaction mixture was separated by preparative TLC (2:3 dichloromethane:hexane), affording three bands. The first band (Rf=0.76) gave the starting material Ru3(CO)10(arphos), the second band (Rf=0.57) gave the major product, characterised as Ru3(CO)9(arphos)PCy3, and the third band was only obtained in trace amounts and was not characterised. The results are as follows. Yield: 21.7mg (33.28%),

18437-78-0, 18437-78-0 Tris(4-fluorophenyl)phosphine 140387, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Shawkataly, Omar Bin; Sirat, Siti Syaida; Khan, Imthyaz Ahmed; Fun, Hoong-Kun; Polyhedron; vol. 63; (2013); p. 173 – 181;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

1079-66-9, Chlorodiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2; To 250 ml three-necked bottle were added 50 ml tetrahydrofuran and 1.1 g metallic sodium, 4.4 g chlorodiphenylphosphine. The mixture reacted at 35¡ã C. for 2.5 h so that chlorodiphenylphosphine reacted completely to form diphenylphosphine sodium, the temperature was dropped to 0¡ã C., the resulted mixture was added to 100 ml tetrahydrofuran system containing 6.3 g lithium o-chlorobenzoate and reacted for 3 h to form lithium diphenylphosphinobenzoate, and then concentrated hydrochloric acid was added to perform hydrolysis, followed by concentration, 3.1 g o-diphenylphosphinobenzoic acid was obtained, HPLC=98.9percent, yield was 50.5percent.

1079-66-9, 1079-66-9 Chlorodiphenylphosphine 66180, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; GAO, Jianxun; Luo, Junlu; Wang, Bibo; Wang, Yamin; Dong, Hongrong; Zhou, Dong; Xu, Lei; Shi, Jinbiao; US2011/77426; (2011); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

166330-10-5, (Oxybis(2,1-phenylene))bis(diphenylphosphine) is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The resulting precursor P – 1 (3.8 g, 10 mmol, 1.0 equivalent), silver oxide (1.2 g, 5 mmol, 50percent yield), solvent acetonitrile 50 ml are sequentially added into a 100 ml flask, 50 ¡ãC light reaction 12 hours; filter, collecting the filtrate, dryness, a colorless solid. The solid with thecopperpowder (0.64 g, 10 mmol, 1.0 equivalent) as for 100 ml flask, add anhydrous non-oxygen second grade nitrile 50 ml, stirring at the room temperature reaction 5 hours; add ligand POP (4.3 g, 8 mmol, 80percent yield), stirring at the room temperature reaction 3 hours; filter, to remove the insoluble solid, collecting the filtrate, reduced pressure drying, be light green solid, that is the crude product. The crude product is dissolved inmethylenechloridesolvent, slow volatilization of the solvent, a large number of colorless crystalline precipitation, filtration to obtain pure complex [(NHC – 1) Cu (POP)]+PF6-(7.2 G, 7.3 mmol), and the yield is 73percent., 166330-10-5

166330-10-5 (Oxybis(2,1-phenylene))bis(diphenylphosphine) 4285986, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Patent; Luoyang Normal College; Wang Zhiqiang; Zhang Zhiqiang; Xu Liancai; Sun Xiaojuan; Xu Chen; Li Hongmei; (21 pag.)CN104610285; (2017); B;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate