With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166330-10-5,(Oxybis(2,1-phenylene))bis(diphenylphosphine),as a common compound, the synthetic route is as follows.
[Cu(CH3CN)4]ClO4 (16.3mg, 0.050mmol) was added to a mixture of pipH (7.4mg, 0.025mmol) and POP (26.9mg, 0.050mmol) in DCM under a stream of dry argon by using Schlenk techniques and a vacuum-line system at room temperature. A lemon-yellow solution was obtained quickly and then stirred for 2h at room temperature. After filtration through the absorbent cotton, layering n-hexane dropwise onto the dichloromethane filtrate carefully produced the target product as yellow crystals a few days later. The sample was obtained in an 84.4percent yield (35.8mg) after being dried using infrared dry technique. Anal. Calc. for C90H67Cl2Cu2N5O10P4 (1a) (1697.307): C, 63.64; H, 3.98; N, 4.12. Found: C, 63.55; H, 3.95; N, 4.12percent. ESI-MS (m/z) (see Fig. S2): 1500.35 [Cu2(pip)(POP)2]+ (calcd 1500.28); 898.195 [Cu(pipH)(POP)]+ (calcd 898.192); 601.093 [Cu(POP)]+ (calcd 601.091). 1H NMR (400MHz, DMSO-d6, delta, ppm) (see Fig. S3): 15.25 (s, 1H, NH), 9.06 (d, J=8.0Hz, 2H), 8.94 (s, 1H), 8.84 (s, 0.5H), 8.78 (d, J=8.0Hz, 1H), 8.47 (s, 1H), 8.37 (d, J=8.0Hz, 1H), 8.24 (s, 1H), 8.03 (s, 1H), 7.92 (s, 0.5H), 7.70 (s, 1H), 7.48?7.01 (m, 40H), 6.84?6.67 (m, 16H). 31P NMR (400MHz, DMSO-d6, delta, ppm): ?11.34, ?13.30, ?19.47. Characteristic IR spectrum (KBr, cm?1): 1094s (ClO4?)., 166330-10-5
The synthetic route of 166330-10-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Niu, Yan-Wen; Liu, Xia; Zhao, Ling; Guo, Ya-Meng; Li, Wen-Xin; Ma, Miao-Miao; Li, Xiu-Ling; Polyhedron; vol. 157; (2019); p. 241 – 248;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate