Day: September 2, 2020

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A (the ratio of 2 : 1 in a hexane solution). Theaddition of compound 2 (0.63 g, 2.5 mmol) to a solution of ester 1b(1.15 g, 5 mmol) in hexane (3 mL) was accompanied by warmingup and deepening of the color. Trituration of the reaction mixtureled to the restructuring of the crystals. The reaction mixture wasallowed to stand at 20-25 C for 24 h, thus obtaining (3,5bistertbutyl4hydroxyphenyl)diphenylphosphoryl(diphenyl)ethoxyphosphoniomethyl ylide (3b) (0.95 g, 59%), m.p. 212-215 C(toluene-heptane, 4 : 1). Found (%): C, 75.35; H, 7.18; P, 9.45.C41H46O3P2. Calculated (%): C, 75.92; H, 7.09; P, 9.57. 31P NMR(CDCl3), delta: deltaP(1) 27.82 (2JP,P = 49.40 Hz, phosphine oxide), deltaP(2)50.49 (2J = 49.4 Hz, ylide). 1H NMR (CDCl3), delta: 1.30 (s, 18 H,CMe3); 1.70 (t, 3 H, CH3, 3JH,H = 7 Hz); 4.80 (q, 2 H, CH2,3JP,H = 3JH,H = 7 Hz); 4.95 (s, 1 H, OH); 6.92 (d, 2 H, C6H2,2JH,H = 2 Hz); 7.40-8.10 (m, 20 H, C6H5). The concentration ofthe toluene-heptane mother liquor gave (3,5bistertbutyl4hydroxyphenyl)bis(diphenylphosphoryl)methane (5b) (0.26 g,16.8%), m.p. 260-263 C (toluene; cf. Ref. 12: 262-264 C).1H NMR (CDCl3), delta: 1.25 (s, 18 H, CMe3); 4.72 (t, 1 H, CH,3JP,H = 12 Hz); 5.10 (s, 1 H, OH); 6.95 (s, 2 H, C6H2); 7.20-8.30(m, 20 H, C6H5)., 719-80-2

As the paragraph descriping shows that 719-80-2 is playing an increasingly important role.

Reference£º
Article; Gazizov; Ismagilov; Shamsutdinova; Tarakanova; Karimova; Russian Chemical Bulletin; vol. 65; 12; (2016); p. 2943 – 2947; Izv. Akad. Nauk, Ser. Khim.; vol. 65; 12; (2016); p. 2943 – 2947,5;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

12150-46-8, 1,1-Bis(diphenylphosphino)ferrocene is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dichloromethane solution of [Fe3(mu3-YTe)(CO)9] {Y = S (1), Se(2), Te(3)} (0.1 mmol) was reacted with bis-(diphenylphosphino) ferrocene (55 mg, 0.1 mmol) at room temperature under continuous stirring condition and nitrogen atmosphere for 3 h. The reaction was monitored by TLC. On completion of the reaction the solution was dried under vacuum and the residue was dissolved in dichloromethane solvent and subjected to chromatographic work-up using preparative TLC. Elution with dichloromethane/hexane (30:70 v/v) solvent mixture separated a red compound, [Fe3YTe(CO)8{eta2-(PPh2)(C5H4)Fe(C5H4)(PPh2)}] {Y = S (8), Se(9), Te(10)} (Yields = 62 mg, 56percent (8), 70 mg, 61percent (9), 86 mg, 72percent (10)) along with unreacted [Fe3YTe(CO)9] and trace amount of a black product and decomposition during the work-up.

12150-46-8, As the paragraph descriping shows that 12150-46-8 is playing an increasingly important role.

Reference£º
Article; Tirkey, Vijaylakshmi; Boddhula, Rajkumar; Mishra, Sasmita; Mobin, Shaikh M.; Chatterjee, Saurav; Journal of Organometallic Chemistry; vol. 794; (2015); p. 88 – 95;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, REFERENCE EXAMPLE 1 Synthesis of o-(diphenylphosphinylmethyl)phenol In a reactor equipped with a thermometer, a stirrer and a condenser were placed 99.2 g of o-(hydroxymethyl)phenol and 400 ml of tetrahydrofuran. They were made into a uniform solution. Thereto was added 184 g of ethyldiphenylphosphinite. The resulting mixture was subjected to reaction for 3 hr with heating and stirring. The reaction mixture was cooled and the resulting white crystal precipitate was separated by filtration and then dried to obtain 180 g of o-(diphenylphosphinylmethyl)phenol. Yield: 73% Melting point: 179 C.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; US4621123; (1986); A;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

50777-76-9, 2-(Diphenylphosphino)benzaldehyde is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 250mL round-bottomed flask equipped with magnetic stir bar and reflux condenser was charged with benzhydrazide (0.68g, 5.00mmol), 2-(diphenylphosphino)benzaldehyde (1.60g, 5.50mmol) and 150mL ethanol. The mixture was heated at boiling temperature under magnetic stirring for 12h. A white precipitate was formed, which was collected by filtration and dried in vacuum. Yield: 1.83g, 89.6%. 1H NMR (400MHz, DMSO-d6, ppm) delta 12.01 (s, 1HNH), 9.19 (d, J=3.6Hz, 1Hbenzene), 8.09 (s, 1HCH), 7.89 (d, J=5.6Hz, 2Hbenzene), 7.58 (d, J=4.8Hz, 1Hbenzene), 7.46-7.54 (m, 3Hbenzene), 7.38-7.44 (m, 7Hbenzene), 7.22 (d, J=3.2Hz, 4Hbenzene), 6.85 (t, J=4.8Hz, 1Hbenzene). Elemental analysis calcd for C26H21N2OP: H 5.18, C 76.46, N 6.86%. Found: H 5.29, C 75.39, N 6.75%. ESI-MS calcd for C26H21N2OP: 408.1391, found 409.1485 [M+H]+, 431.1318 [M+Na]+., 50777-76-9

Big data shows that 50777-76-9 is playing an increasingly important role.

Reference£º
Article; Zheng, Sijia; Zhao, Liang; Wei, Jianwei; He, Cheng; Liu, Guangzhou; Duan, Chunying; Inorganic Chemistry Communications; vol. 109; (2019);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

17261-28-8, 2-(Diphenylphosphino)benzoic acid is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (1R,5S)-(?)-cytisine (571mg, 3.00mmol) in CH3OH (10mL) was added platinum (IV) oxide hydrate (80percent Pt) (82mg, 0.30mmol) and the mixture was stirred at room temperature under a hydrogen atmosphere (balloon) for 48h. The solids were removed by filtration through Celite and the filter cake was washed with CH2Cl2/CH3OH (9:1). The filtrate was evaporated under reduced pressure to give the crude product. Purification by flash column chromatography (silica gel, CH2Cl2/CH3OH/Et3N=20:1:0.5) gave lactam 4 (314mg, 54percent) as a white solid [8b]. To a mixture of 2-diphenylphosphinobenzoic acid (76mg, 0.25mmol), N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide (58mg, 0.30mmol) and hydroxybenzotriazole (41mg, 0.30mmol) in dry CH2Cl2 (5mL) under an argon atmosphere lactam 4 (63mg, 0.32mmol) was added at room temperature. The mixture was stirred at room temperature for 24h and then was directly subjected to flash column chromatography (silica gel, CH2Cl2/CH3OH=50:1) to give 116mg (97percent yield) of 5 as a white solid; m.p. 194?196¡ãC. [alpha]D20=?18.2 (c 0.31, CHCl3). 1H NMR (600MHz, CDCl3, 293K): delta=7.42 (t, JH,H=7.4Hz, 1H, Har), 7.35?7.30 (m, 6H, Har), 7.29?7.28 (m, 3H, Har), 7.25 (dt, JH,H=7.7Hz, 1H, Har), 7.23?7.21 (m, 2H, Har), 7.02 (dd, JH,H=7.3, 4.0Hz, 1H, Har), 5.06 (d, JH,H=13.9Hz, 1H, 2-Heq), 4.60 (d, JH,H=13.8Hz, 1H, 4-Heq), 3.50?3.46 (m, 1H, 12-H), 3.44 (d, JH,H=12.5Hz, 1H, 6-H), 2.98 (d, JH,H=12.5Hz, 1H, 6-H), 2.81 (d, JH,H=14.0Hz, 1H, 4-Hax), 2.78 (d, JH,H=14.0Hz, 1H, 2-Hax), 2.52?2.43 (m, 2H, 9-H, 10-H), 2.22 (dq, JH,H=13.0, 3.0Hz, 1H, 11-H), 1.96?1.85 (m, 4H, 9-H, 10-H, 11-H, 13-H), 1.80 (brs, 2H, 1-H, 5-H), 1.70?1.63 (m, 1H, 13-H) ppm. 13C NMR (150.9MHz, CDCl3, 293K): delta=170.32 (Cq, C=O, lactam), 170.12 (Cq, C=O, amide), 142.65 (d, J31P,13C=32.6Hz, Cq, Car), 136.55 (d, J31P,13C=9.9Hz, Cq, Car), 136.14 (d, J31P,13C=10.1Hz, Cq, Car), 133.99 (d J31P,13C=20.3Hz, 2 CH, Car), 133.73 (CH, Car), 133.28 (d, J31P,13C=19.6Hz, 2 CH, Car), 131.67 (Cq, CCO), 129.79 (CH, Car), 128.82 (CH, Car), 128.70 (CH, Car), 128.50 (CH, Car), 128.49 (d, J31P,13C=6.5Hz, 2 CH, Car), 128.32 (d, J31P,13C=6.9Hz, 2 CH, Car), 127.52 (d, J31P,13C=7.1Hz, CH, Car), 59.53 (CH, 12-C), 51.80 (CH2, 6-C), 45.72 (CH2, 4-C), 41.63 (CH2, 2-C), 33.02 (2 CH2, 9-C, 10-C), 32.70 (CH, 1-C), 28.15 (CH, 5-C), 28.10 (CH2, 11-C), 20.16 (CH2, 13-C) ppm. 31P{1H} NMR (242.92MHz, CDCl3, 293K): delta=?12.20ppm. IR(KBr): nu=3058, 2922, 2861, 1624, 1584, 1439, 1422, 1254, 1182, 779, 692cm?1. MS (ESI): m/z=483 (100, [M+1]+), 289 (52). C30H31N2O2P (482.55): calcd. C 74.67, H 6.48, N 5.81, found C 74.58, H 6.71, N 5.89., 17261-28-8

As the paragraph descriping shows that 17261-28-8 is playing an increasingly important role.

Reference£º
Article; Philipova, Irena; Stavrakov, Georgi; Vassilev, Nikolay; Nikolova, Rositsa; Shivachev, Boris; Dimitrov, Vladimir; Journal of Organometallic Chemistry; vol. 778; (2015); p. 10 – 20;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

719-80-2, Ethoxydiphenylphosphine is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

719-80-2, A mixed solution of Compound 558-4 (10.0 g, 0.023 mol), nickel(II) chloride (1.79 g, 0.0138 mol), and benzonitrile was heated to 180 C. and stirred for 1 hour in a two neck round bottom flask (two neck r.b.f) under nitrogen. Ph2POEt (ethyl diphenylphosphinite) (8.48 g, 0.0368 mol) was slowly added dropwise to the above mixture and then stirred for 2 hours. The reaction mixture cooled to room temperature was extracted with MC (methylene chloride)/H2O and dried using MgSO4 and then filtered. After being concentrated, the resultant reaction product was separated by column chromatography (SiO2, hexane_MC=2:1). As a result, a white solid compound 571 (6.4 g, 58%) was obtained.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HEESUNG MATERIAL LTD.; JANG, SO HYUN; KIM, KEE YONG; HONG, JANG MI; CHOI, JIN SEOK; CHOI, DAE HYUK; EUM, SUNG JIN; LEE, JOO DONG; (114 pag.)KR101558495; (2015); B1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.083 mmol), Cesium Fluoride (70 mg, 0.461 mmol), Ethoxydiphenylphosphane (78 mg, 0.33 mmol), Acetonitrile (1 ml): Reaction Time: 16 h; Rf: 0.3 (1 :3 EtOAc:Pet Ether); White Solid; 17.5 mg, 75 %; NMR (400 MHz, CDC13, TMS) delta 7.74-7.63 (m, 6H), 7.59-7.51 (m, 3H), 7.50-7.40 (m, 6H); 13C NMR (100 MHz, CDCI3, TMS) delta 132.5 (d, J = 104.0 Hz), 132.1 (d, J = 10.0 Hz), 131.9 (d, J= 2.3 Hz); 128.5 (d, J = 12.4 Hz); 31P NMR (162 MHz, CDC13) delta 29.2; Mass (M + Na)+ 301; Known Compound, Lit. K. Prokop, D. Goldberg, J. Am. Chem. Soc. 2012, 134, 8014.

The synthetic route of 719-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; MHASKE, Santosh Baburao; DHOKALE, Ranjeet Ashokrao; WO2014/24212; (2014); A1;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.719-80-2,Ethoxydiphenylphosphine,as a common compound, the synthetic route is as follows.

719-80-2, Ethyl diphenylphosphinite (5.7 g, 0.025 mol) and diethyl ether (30 ml) were combined in a 100 ml round bottom flask equipped with a water condensor topped by a glass tee leading to a source of dry nitrogen and a mineral oil bubbler. After cooling the flask in an ice bath, 1 (7.35 g, 0.035 mol) was added. The reaction mixture was then heated at reflux for 18 h. The ether was removed by rotary evaporation at aspirator pressure to yield a clear oil which crystallized on the addition of fresh ether. The crystals were filtered and washed once with a smal portion of ice cold ether to give 5.7 g (69%) 17 (mp = 66-69 C). After recrystallization from benzene and again from Skelly B, the melting point was 68.5-69.5 C. 19F NMR (CDCl3) (ppm): delta = -59.2 (d, 2JPF = 71 Hz); 31P NMR (CDCl3) (ppm): delta = 27.5 (t, 2JPF = 71 Hz); 13C NMR (CDCl3) (ppm): delta = 123.0 (td, 1JCF = 336 Hz, 1JCP = 101 Hz), d = 125.5 (d, 1JCP = 106 Hz, a-carbon of ring), [d = 129.0 (d, JCP = 13.2 Hz) and d = 132.4 (d, JCP = 10.3 Hz) (o- and m-ring carbons)], d = 133.8 (d, 4JCP = 2.9 Hz, p-ring carbon); 1H NMR (CDCl3) (ppm): delta = 7.5-8.2 (multiplet). GC-MS, m/z (relative intensity): 201 (15), 77 (13), 39 (100); molecular ion 330, 332; intensity very low: IR (P=O) 1222 cm-1:Anal. Calcd. for C12H10OPCF2Br: C, 47.13%; H, 3.02%. Found C, 47.18%; H, 3.02%.

719-80-2 Ethoxydiphenylphosphine 69754, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Flynn, Richard M.; Burton, Donald J.; Journal of Fluorine Chemistry; vol. 132; 10; (2011); p. 815 – 828;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15929-43-8,Bis(4-(trifluoromethyl)phenyl)phosphine oxide,as a common compound, the synthetic route is as follows.

General procedure: To an 10mL oven-dried Schlenk tube under argon atmosphere were added R1R2P(O)H (1.0 mmol) and THF (2.0 mL), stirring the solution until all the solid was totally dissolved, and then MeC(O)Cl (2.0 mmol) was added to the solution and the mixture was stirred at room temperature or 50oC for overnight. After reaction, the excessive MeC(O)Cl, byproduct AcOH and solvent THF were removed under vacuum to afford pure R1R2PCl., 15929-43-8

As the paragraph descriping shows that 15929-43-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jian-Qiu; Yang, Shangdong; Han, Li-Biao; Tetrahedron Letters; vol. 61; 10; (2020);,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate

13885-09-1, 2-(Diphenylphosphino)biphenyl is a chiral-phosphine-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of [Fe2(CO)6{mu-SC6H3(CH3)S}] (0.043 g,0.1 mmol) and ethyl diphenylphosphinite (0.023 g,0.1 mmol) in CH2Cl2(5 mL) was added a solution of Me3NO¡¤2H2O (0.011 g, 0.1 mmol) in MeCN (5 mL). The mixture was stirred at room temperature for 1 h and then the solvent was reduced on a rotary evaporator. The residue was subjected to TLC using CH2Cl2/petroleum ether = 1:4(v/v) as eluent., 13885-09-1

13885-09-1 2-(Diphenylphosphino)biphenyl 12976978, achiral-phosphine-ligands compound, is more and more widely used in various.

Reference£º
Article; Lin, Hui-Min; Mu, Chao; Li, Ao; Liu, Xu-Feng; Li, Yu-Long; Jiang, Zhong-Qing; Wu, Hong-Ke; Transition Metal Chemistry; vol. 44; 5; (2019); p. 491 – 498;,
Phosphine ligand
Chiral phosphine ligands in asymmetric synthesis. Molecular structure and absolute configuration of (1,5-cyclooctadiene)-(2S,3S)-2,3-bis(diphenylphosphino)butanerhodium(I) perchlorate tetrahydrofuran solvate